PMID- 38244155
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1573-6881 (Electronic)
IS  - 0145-479X (Linking)
VI  - 56
IP  - 2
DP  - 2024 Apr
TI  - Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model 
      by promoting DNAJB6 gene transcription.
PG  - 171-180
LID - 10.1007/s10863-024-10002-5 [doi]
AB  - To verify the protective effect of circDNAJB6 on Bronchopulmonary dysplasia (BPD) 
      cell and animal models and to explore the possible mechanism of its protective 
      effect. The function of circDNAJB6 was investigated at the cell and animal 
      levels. Nuclear and Cytoplasmic RNA extraction kits and fluorescence in situ 
      hybridization (FISH) were used to explore the distribution of circDNAJB6 in 
      cells, and the potential mechanism of circDNAJB6 was verified by q-PCR, 
      luciferase assays and rescue experiments.CircDNAJB6 is abundant in breast milk 
      exosomes. Overexpression of circDNAJB6 can ameliorate damage in BPD models caused 
      by hyperoxia exposure in vivo and in vitro. Mechanistically, circDNAJB6 can 
      target the downstream DNAJB6 gene and promote the transcription of DNAJB6, 
      exertive a protective effect on the experimental BPD model. Our results showed 
      that circDNAJB6 alleviated damage and inhibited the proliferation of alveolar 
      epithelial cells in the BPD model by promoting transcription of parent gene 
      DNAJB6. Human milk exosome-derived circDNAJB6 provides new directions for 
      preventing and treating BPD.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Li, Yubai
AU  - Li Y
AD  - Division of Neonatology, Department of Pediatrics, Shenzhen People's Hospital, 
      The Second Clinical Medical College of Jinan University, First Affiliated 
      Hospital of Southern University of Science and Technology, Shenzhen, 518020, 
      China.
FAU - Yu, Boshi
AU  - Yu B
AD  - Division of Neonatology, Department of Pediatrics, Shenzhen People's Hospital, 
      The Second Clinical Medical College of Jinan University, First Affiliated 
      Hospital of Southern University of Science and Technology, Shenzhen, 518020, 
      China.
FAU - Li, Huimin
AU  - Li H
AD  - Department of Pediatrics, Nanjing Maternity and Child Health Care Hospital, 
      Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.
FAU - Hou, Weiwei
AU  - Hou W
AD  - The Yangzhou School of Clinical Medicine of Nanjing Medical University, Yangzhou, 
      225000, China.
FAU - Yin, Jing
AU  - Yin J
AD  - Department of Pediatrics, Nanjing Maternity and Child Health Care Hospital, 
      Women's Hospital of Nanjing Medical University, Nanjing, 210004, China. 
      654516691@qq.com.
FAU - Zhou, Yahui
AU  - Zhou Y
AD  - Division of Neonatology, Department of Pediatrics, Wuxi Children's Hospital, 
      Children's Hospital affiliated to Jiangnan University, Wuxi, 214000, China. 
      yahuizhou@njmu.edu.cn.
FAU - Yu, Zhangbin
AU  - Yu Z
AD  - Division of Neonatology, Department of Pediatrics, Shenzhen People's Hospital, 
      The Second Clinical Medical College of Jinan University, First Affiliated 
      Hospital of Southern University of Science and Technology, Shenzhen, 518020, 
      China. yuzhangbin@126.com.
LA  - eng
GR  - 82001597/National Natural Science Foundation of China/
GR  - JCYJ20220530152415034/Natural Science Foundation of Shenzhen Municipality/
PT  - Journal Article
DEP - 20240120
PL  - United States
TA  - J Bioenerg Biomembr
JT  - Journal of bioenergetics and biomembranes
JID - 7701859
RN  - 0 (DNAJB6 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Molecular Chaperones)
RN  - 0 (HSP40 Heat-Shock Proteins)
SB  - IM
MH  - Animals
MH  - Infant, Newborn
MH  - Female
MH  - Humans
MH  - *Bronchopulmonary Dysplasia/genetics
MH  - Milk, Human
MH  - Animals, Newborn
MH  - *Exosomes/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Transcription, Genetic
MH  - Disease Models, Animal
MH  - Nerve Tissue Proteins/genetics
MH  - Molecular Chaperones/genetics
MH  - HSP40 Heat-Shock Proteins/genetics
OTO - NOTNLM
OT  - Alveolar type II cell
OT  - Bronchopulmonary dysplasia
OT  - CircRNA
OT  - DNAJB6
OT  - Exosomes
EDAT- 2024/01/20 21:42
MHDA- 2024/04/08 06:43
CRDT- 2024/01/20 11:19
PHST- 2024/01/09 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/01/20 21:42 [pubmed]
PHST- 2024/01/20 11:19 [entrez]
AID - 10.1007/s10863-024-10002-5 [pii]
AID - 10.1007/s10863-024-10002-5 [doi]
PST - ppublish
SO  - J Bioenerg Biomembr. 2024 Apr;56(2):171-180. doi: 10.1007/s10863-024-10002-5. 
      Epub 2024 Jan 20.