PMID- 38244791
OWN - NLM
STAT- MEDLINE
DCOM- 20240228
LR  - 20240228
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 351
DP  - 2024 Apr 15
TI  - The impact of matching for reproductive status on the comparison of magnetic 
      spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the 
      medial prefrontal cortex of women with major depression.
PG  - 396-402
LID - S0165-0327(24)00155-1 [pii]
LID - 10.1016/j.jad.2024.01.140 [doi]
AB  - OBJECTIVES: The role played by medial prefrontal cortex (MPFC) glutamate (Glu) 
      and gamma-aminobutyric acid (GABA) in the pathophysiology and the treatment of 
      major depression (MD) is increasingly recognized. Although measurements of MPFC 
      GABA and Glu have been shown to be sensitive to physiological fluctuations of 
      female hormones, none of the magnetic resonance spectroscopy (MRS) investigations 
      of MPFC Glu and GABA in MD have controlled for possible bias effect of the 
      reproductive stage of the women included. METHODS: MPFC Glu and GABA+ (which 
      include homocarnosine and macromolecules) referenced to creatine and 
      phosphocreatine, were measured via magnetic resonance spectroscopy (MRS) using a 
      3-Tesla magnet in 24 women with MD and 24 healthy women paired for reproductive 
      status. All participants were unmedicated. RESULTS: There were no statistical 
      differences in either MPFC Glu [95 % CI: (-0.025, 0.034)] or MPFC GABA+ [95 % CI: 
      (-0.005, 0.017)] between women with MD and healthy controls. CONCLUSIONS: Our 
      investigation does not support abnormalities in measurement of MPFC Glu and GABA 
      in MD women when stringent control for reproductive status is performed. As a 
      result of the inherent limitations of MRS methodology, our results do not 
      preclude glutamatergic and GABAergic dysregulations in the MPFC of women with MD.
CI  - Copyright (c) 2024. Published by Elsevier B.V.
FAU - Tran, Kim H
AU  - Tran KH
AD  - University of Alberta, Department of Psychiatry, Edmonton, AB, Canada.
FAU - Luki, Jessica
AU  - Luki J
AD  - University of Alberta, Department of Psychiatry, Edmonton, AB, Canada.
FAU - Hanstock, Sarah
AU  - Hanstock S
AD  - University of Alberta, Department of Psychiatry, Edmonton, AB, Canada.
FAU - Hanstock, Christopher C
AU  - Hanstock CC
AD  - University of Alberta, Department of Biomedical Engineering, Edmonton, AB, 
      Canada.
FAU - Seres, Peter
AU  - Seres P
AD  - University of Alberta, Department of Biomedical Engineering, Edmonton, AB, 
      Canada.
FAU - Aitchison, Katherine
AU  - Aitchison K
AD  - University of Alberta, Department of Psychiatry, Edmonton, AB, Canada; University 
      of Alberta, Department of Medical Genetics, Edmonton, AB, Canada; University of 
      Alberta, Neuroscience and Mental Health Institute, Edmonton, AB, Canada; 
      University of Alberta, Women and Children's Research Institute, Edmonton, AB, 
      Canada; Northern Ontario School of Medicine, Division of Clinical Sciences, 
      Psychiatry Section, Thunder Bay, ON, Canada.
FAU - Shandro, Tami
AU  - Shandro T
AD  - Lois Hole Hospital for Women, Royal Alexandra Hospital, Edmonton, AB, Canada.
FAU - Le Melledo, Jean-Michel
AU  - Le Melledo JM
AD  - University of Alberta, Department of Psychiatry, Edmonton, AB, Canada. Electronic 
      address: jlemelle@ualberta.ca.
LA  - eng
PT  - Journal Article
DEP - 20240119
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Female
MH  - Humans
MH  - *Glutamic Acid
MH  - *Depressive Disorder, Major/drug therapy
MH  - Depression
MH  - Prefrontal Cortex/diagnostic imaging
MH  - gamma-Aminobutyric Acid
OTO - NOTNLM
OT  - Depression
OT  - GABA
OT  - Glutamate
OT  - Magnetic resonance spectroscopy
OT  - Medial prefrontal cortex
COIS- Declaration of competing interest All other authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2024/01/21 00:42
MHDA- 2024/02/28 06:44
CRDT- 2024/01/20 19:17
PHST- 2023/06/26 00:00 [received]
PHST- 2024/01/08 00:00 [revised]
PHST- 2024/01/14 00:00 [accepted]
PHST- 2024/02/28 06:44 [medline]
PHST- 2024/01/21 00:42 [pubmed]
PHST- 2024/01/20 19:17 [entrez]
AID - S0165-0327(24)00155-1 [pii]
AID - 10.1016/j.jad.2024.01.140 [doi]
PST - ppublish
SO  - J Affect Disord. 2024 Apr 15;351:396-402. doi: 10.1016/j.jad.2024.01.140. Epub 
      2024 Jan 19.