PMID- 38245739 OWN - NLM STAT- MEDLINE DCOM- 20240122 LR - 20240131 IS - 2662-7671 (Electronic) IS - 2662-7671 (Linking) VI - 24 IP - 1 DP - 2024 Jan 20 TI - Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study. PG - 43 LID - 10.1186/s12906-024-04349-w [doi] LID - 43 AB - OBJECTIVE: To investigate the changes in amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) values before and after acupuncture in young women with non-menstrual migraine without aura (MWoA) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI). METHODS: Patients with non-menstrual MWoA (Group 1, n = 50) and healthy controls (Group 2, n = 50) were recruited. fMRI was performed in Group 1 at 2 time points: before acupuncture (time point 1, TP1); and after the end of all acupuncture sessions (time point 2, TP2), and performed in Group 2 as a one-time scan. Patients in Group 1 were assessed with the Migraine Disability Assessment Questionnaire (MIDAS) and the Short-Form McGill Pain Questionnaire (SF-MPQ) at TP1 and TP2 after fMRI was performed. The ALFF and DC values were compared within Group 1 at two time points and between Group 1 and Group2. The correlation between ALFF and DC values with the statistical differences and the clinical scales scores were analyzed. RESULTS: Brain activities increased in the left fusiform gyrus and right angular gyrus, left middle occipital gyrus, and bilateral prefrontal cortex and decreased in left inferior parietal lobule in Group 1, which had different ALFF values compared with Group 2 at TP1. The bilateral fusiform gyrus, bilateral inferior temporal gyrus and right middle temporal gyrus increased and right angular gyrus, right superior marginal gyrus, right inferior parietal lobule, right middle occipital gyrus, right superior frontal gyrus, right middle frontal gyrus, right anterior central gyrus, and right supplementary motor area decreased in activity in Group 1 had different DC values compared with Group 2 at TP1. ALFF and DC values of right inferior temporal gyrus, right fusiform gyrus and right middle temporal gyrus were decreased in Group1 at TP1 compared with TP2. ALFF values in the left middle occipital area were positively correlated with the pain degree at TP1 in Group1 (correlation coefficient r, r = 0.827, r = 0.343; P < 0.01, P = 0.015). The DC values of the right inferior temporal area were positively correlated with the pain degree at TP1 in Group 1 (r = 0.371; P = 0.008). CONCLUSION: Spontaneous brain activity and network changes in young women with non-menstrual MwoA were altered by acupuncture. The right temporal area may be an important target for acupuncture modulated brain function in young women with non-menstrual MwoA. CI - (c) 2024. The Author(s). FAU - Yang, Yu-Chan AU - Yang YC AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Wei, Xiang-Yu AU - Wei XY AD - Institute of Acupuncture and Anesthesia, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Zhang, Ying-Ying AU - Zhang YY AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Xu, Chun-Yang AU - Xu CY AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Cheng, Jian-Ming AU - Cheng JM AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Gong, Zhi-Gang AU - Gong ZG AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Chen, Hui AU - Chen H AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Huang, Yan-Wen AU - Huang YW AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Yuan, Jie AU - Yuan J AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Xu, Hui-Hui AU - Xu HH AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Wang, Hui AU - Wang H AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Zhan, Song-Hua AU - Zhan SH AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. zhansonghua@sina.com. FAU - Tan, Wen-Li AU - Tan WL AD - Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. tanying2245@163.com. LA - eng PT - Journal Article DEP - 20240120 PL - England TA - BMC Complement Med Ther JT - BMC complementary medicine and therapies JID - 101761232 SB - IM MH - Humans MH - Female MH - Magnetic Resonance Imaging/methods MH - *Migraine without Aura MH - *Acupuncture Therapy MH - Occipital Lobe/diagnostic imaging MH - Pain PMC - PMC10799457 OTO - NOTNLM OT - Acupuncture OT - Blood-oxygen-level-dependent functional magnetic resonance imaging OT - Degree centrality OT - Low-frequency fluctuation OT - Non-menstrual migraine without aura COIS- The authors declare no competing interests. EDAT- 2024/01/21 00:42 MHDA- 2024/01/22 06:42 PMCR- 2024/01/20 CRDT- 2024/01/20 23:28 PHST- 2023/05/22 00:00 [received] PHST- 2024/01/12 00:00 [accepted] PHST- 2024/01/22 06:42 [medline] PHST- 2024/01/21 00:42 [pubmed] PHST- 2024/01/20 23:28 [entrez] PHST- 2024/01/20 00:00 [pmc-release] AID - 10.1186/s12906-024-04349-w [pii] AID - 4349 [pii] AID - 10.1186/s12906-024-04349-w [doi] PST - epublish SO - BMC Complement Med Ther. 2024 Jan 20;24(1):43. doi: 10.1186/s12906-024-04349-w.