PMID- 38247382
OWN - NLM
STAT- MEDLINE
DCOM- 20240304
LR  - 20240304
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 13
IP  - 3
DP  - 2024 Feb
TI  - Target volumes comparison between postoperative simulation magnetic resonance 
      imaging and preoperative diagnostic magnetic resonance imaging for prone breast 
      radiotherapy after breast-conserving surgery.
PG  - e6956
LID - 10.1002/cam4.6956 [doi]
LID - e6956
AB  - BACKGROUND: This study investigated the differences in target volumes between 
      preoperative magnetic resonance imaging (MRIpre) and postoperative MRI (MRIpost) 
      for breast radiotherapy after breast-conserving surgery (BCS) using deformable 
      image registration (DIR). METHODS AND MATERIALS: Seventeen eligible patients who 
      underwent whole-breast irradiation in the prone position after BCS were enrolled. 
      On MRIpre, the gross tumor volume (GTV) was delineated as GTVpre, which was then 
      expanded by 10 mm to represent the preoperative lumpectomy cavity (LC), denoted 
      as LCpre. The LC was expanded to the clinical target volume (CTV) and planning 
      target volume (PTV) on the MRIpre and MRIpost, denoted as CTVpre, CTVpost, 
      PTVpre, and PTVpost, respectively. The MIM software system was used to register 
      the MRIpre and MRIpost using DIR. Differences were evaluated regarding target 
      volume, distance between the centers of mass (dCOM), conformity index (CI), and 
      degree of inclusion (DI). The relationship between CI(LC) /CI(PTV) and the 
      clinical factors was also assessed. RESULTS: Significant differences were 
      observed in LC and PTV volumes between MRIpre and MRIpost (p < 0.0001). LCpre was 
      0.85 cm(3) larger than LCpost, while PTVpre was 29.38 cm(3) smaller than PTVpost. 
      The dCOM between LCpre and LCpost was 1.371 cm, while that between PTVpre and 
      PTVpost reduced to 1.348 cm. There were statistically significant increases in CI 
      and DI for LCpost-LCpre and PTVpost-PTVpre (CI = 0.221, 0.470; DI = 0.472, 
      0.635). No obvious linear correlations (p > 0.05) were found between CI and GTV, 
      primary tumor volume-to-breast volume ratio, distance from the primary tumor to 
      the nipple and chest wall, and body mass index. CONCLUSIONS: Despite using DIR 
      technology, the spatial correspondence of target volumes between MRIpre and 
      MRIpost was suboptimal. Therefore, relying solely on preoperative diagnostic MRI 
      with DIR for postoperative LC delineation is not recommended.
CI  - (c) 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Jin, Ying
AU  - Jin Y
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 
      Jinan, China.
FAU - Zhao, Changhui
AU  - Zhao C
AD  - Department of Oncology, Jinan Third People's Hospital, Jinan Cancer Hospital, 
      Jinan, China.
FAU - Wang, Lizhen
AU  - Wang L
AD  - Department of Medical Physics, Shandong Cancer Hospital and Institute, Shandong 
      First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
FAU - Su, Ya
AU  - Su Y
AD  - Department of Medical Physics, Shandong Cancer Hospital and Institute, Shandong 
      First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
FAU - Shang, Dongping
AU  - Shang D
AUID- ORCID: 0000-0002-6930-5940
AD  - Department of Medical Physics, Shandong Cancer Hospital and Institute, Shandong 
      First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
FAU - Li, Fengxiang
AU  - Li F
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 
      Jinan, China.
FAU - Wang, Jinzhi
AU  - Wang J
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 
      Jinan, China.
FAU - Liu, Xijun
AU  - Liu X
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 
      Jinan, China.
FAU - Li, Jianbin
AU  - Li J
AUID- ORCID: 0000-0002-4053-1792
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 
      Jinan, China.
FAU - Wang, Wei
AU  - Wang W
AUID- ORCID: 0000-0003-0490-9230
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 
      Jinan, China.
LA  - eng
GR  - ZR2020QH260/The National Natural Science Foundation of Shandong Provence/
GR  - ts 20190982/Taishan Scholars Program of Shandong Province/
PT  - Journal Article
DEP - 20240122
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
SB  - IM
MH  - Humans
MH  - *Mastectomy, Segmental
MH  - *Tomography, X-Ray Computed/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Postoperative Period
PMC - PMC10905334
OTO - NOTNLM
OT  - breast cancer
OT  - deformable image registration
OT  - preoperative diagnostic magnetic resonance image
OT  - target volume comparison
COIS- The authors have no competing interests to declare relevant to this article's 
      content.
EDAT- 2024/01/22 06:42
MHDA- 2024/03/04 06:49
PMCR- 2024/01/22
CRDT- 2024/01/22 03:43
PHST- 2023/12/27 00:00 [revised]
PHST- 2023/06/28 00:00 [received]
PHST- 2024/01/10 00:00 [accepted]
PHST- 2024/03/04 06:49 [medline]
PHST- 2024/01/22 06:42 [pubmed]
PHST- 2024/01/22 03:43 [entrez]
PHST- 2024/01/22 00:00 [pmc-release]
AID - CAM46956 [pii]
AID - 10.1002/cam4.6956 [doi]
PST - ppublish
SO  - Cancer Med. 2024 Feb;13(3):e6956. doi: 10.1002/cam4.6956. Epub 2024 Jan 22.