PMID- 38247531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 13
IP  - 1
DP  - 2024 Jan 16
TI  - Oxidative Balance Score and New-Onset Type 2 Diabetes Mellitus in Korean Adults 
      without Non-Alcoholic Fatty Liver Disease: Korean Genome and Epidemiology 
      Study-Health Examinees (KoGES-HEXA) Cohort.
LID - 10.3390/antiox13010107 [doi]
LID - 107
AB  - The oxidative balance score (OBS) is a novel composite of pro- and anti-oxidative 
      markers for assessing the risk of cardiometabolic diseases and non-alcoholic 
      fatty liver disease (NAFLD). However, it has not yet been established whether the 
      OBS is related to type 2 diabetes mellitus (T2DM), especially in a population 
      without NALFD. Therefore, we aimed to investigate the longitudinal effect of the 
      OBS on T2DM in a large cohort of Korean adults without NALFD. Data were assessed 
      from 9798 participants without NALFD from the Korean Genome and Epidemiology 
      Study-Health Examinees (KoGES-HEXA) cohort. The participants were divided into 
      three groups according to OBS tertiles, identified as T1-T3. We prospectively 
      assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for 
      new-onset T2DM using multivariable Cox proportional hazard regression models over 
      6 years following the baseline survey. During the mean 3.5 years of follow-up, 
      145 individuals (1.48%; 56 men and 89 women) developed T2DM. The HRs of T2DM for 
      the OBS tertiles were 0.79 (95% CI, 0.53-1.18) and 0.60 (95% CI, 0.39-0.93) in 
      the T2 and T3 groups after adjusting for metabolic parameters in subjects without 
      NALFD, respectively; however, the T2 group did not show statistical significance 
      toward a decrease in incident T2DM. A low OBS may be a useful predictive marker 
      in new-onset T2DM for middle-aged and older subjects without NALFD. This implies 
      that the OBS could be an additional valuable tool for assessing the incidence of 
      T2DM among individuals without NAFLD.
FAU - Moon, Mid-Eum
AU  - Moon ME
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul 
      03722, Republic of Korea.
AD  - Department of Family Medicine, Gangnam Severance Hospital, Seoul 06273, Republic 
      of Korea.
FAU - Jung, Dong Hyuk
AU  - Jung DH
AUID- ORCID: 0000-0002-3411-0676
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul 
      03722, Republic of Korea.
AD  - Department of Family Medicine, Yongin Severance Hospital, Yongin 16995, Republic 
      of Korea.
FAU - Heo, Seok-Jae
AU  - Heo SJ
AUID- ORCID: 0000-0002-8764-7995
AD  - Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei 
      University College of Medicine, Seoul 03722, Republic of Korea.
FAU - Park, Byoungjin
AU  - Park B
AUID- ORCID: 0000-0003-1733-5301
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul 
      03722, Republic of Korea.
AD  - Department of Family Medicine, Yongin Severance Hospital, Yongin 16995, Republic 
      of Korea.
FAU - Lee, Yong Jae
AU  - Lee YJ
AUID- ORCID: 0000-0002-6697-476X
AD  - Department of Family Medicine, Yonsei University College of Medicine, Seoul 
      03722, Republic of Korea.
AD  - Department of Family Medicine, Gangnam Severance Hospital, Seoul 06273, Republic 
      of Korea.
LA  - eng
GR  - NRF- 2022R1A2C1013106/the Ministry of Science and ICT of Korea/
PT  - Journal Article
DEP - 20240116
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10812514
OTO - NOTNLM
OT  - KoGES-HEXA cohort
OT  - NALFD
OT  - oxidative balance score
OT  - type 2 diabetes
COIS- All the authors declare that the study was performed without any commercial or 
      financial association that might be perceived as potential conflicts of interest.
EDAT- 2024/01/22 06:42
MHDA- 2024/01/22 06:43
PMCR- 2024/01/16
CRDT- 2024/01/22 04:23
PHST- 2023/11/16 00:00 [received]
PHST- 2023/12/15 00:00 [revised]
PHST- 2023/12/25 00:00 [accepted]
PHST- 2024/01/22 06:43 [medline]
PHST- 2024/01/22 06:42 [pubmed]
PHST- 2024/01/22 04:23 [entrez]
PHST- 2024/01/16 00:00 [pmc-release]
AID - antiox13010107 [pii]
AID - antioxidants-13-00107 [pii]
AID - 10.3390/antiox13010107 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2024 Jan 16;13(1):107. doi: 10.3390/antiox13010107.