PMID- 38247847
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240201
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 13
IP  - 2
DP  - 2024 Jan 15
TI  - The Protective Effect of a Human Umbilical Cord Mesenchymal Stem Cell Supernatant 
      on UVB-Induced Skin Photodamage.
LID - 10.3390/cells13020156 [doi]
LID - 156
AB  - The skin is constantly exposed to a range of environmental stressors, including 
      ultraviolet (UV) radiation, which can cause damage to the skin. Repairing 
      UV-damaged skin has been a major focus of research in recent years. The 
      therapeutic potential of human umbilical cord mesenchymal stem cells (HUCMSCs) 
      exhibits anti-photoaging properties. In this study, we developed a strategy for 
      concentrating an HUCMSC supernatant, and examined the protective effects of CHS 
      on UVB exposure in vitro and in vivo. Our results demonstrate that CHS repairs 
      UVB exposure by promoting cell viability and migration and reducing senescent and 
      apoptosis cells. We further found that the photoprotective effect of CHS is due 
      to autophagy activation. Moreover, CHS reduces wrinkles and senescent cells, 
      increases collagen expression, and improves immune function in UVB 
      exposure-induced skin damage. In summary, our study provides a new approach for 
      repairing cell damage, and suggests that CHS might be a potential candidate for 
      preventing UVB-induced skin photodamage.
FAU - Cheng, Lin
AU  - Cheng L
AD  - Department of Pharmacology, West China School of Basic Medical Sciences and 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
FAU - Liu, Jiaqi
AU  - Liu J
AD  - Department of Pharmacology, West China School of Basic Medical Sciences and 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Department of Pharmacology, West China School of Basic Medical Sciences and 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
FAU - Hu, Huozhen
AU  - Hu H
AD  - Department of Pharmacology, West China School of Basic Medical Sciences and 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
FAU - Zhou, Liming
AU  - Zhou L
AD  - Department of Pharmacology, West China School of Basic Medical Sciences and 
      Forensic Medicine, Sichuan University, Chengdu 610041, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240115
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Humans
MH  - *Skin
MH  - Apoptosis
MH  - Autophagy
MH  - *Mesenchymal Stem Cells
MH  - Umbilical Cord
PMC - PMC10814745
OTO - NOTNLM
OT  - UVB
OT  - human umbilical cord mesenchymal stem cell supernatant
OT  - skin photodamage
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/22 06:42
MHDA- 2024/01/23 06:42
PMCR- 2024/01/15
CRDT- 2024/01/22 04:33
PHST- 2023/08/13 00:00 [received]
PHST- 2023/09/19 00:00 [revised]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/01/23 06:42 [medline]
PHST- 2024/01/22 06:42 [pubmed]
PHST- 2024/01/22 04:33 [entrez]
PHST- 2024/01/15 00:00 [pmc-release]
AID - cells13020156 [pii]
AID - cells-13-00156 [pii]
AID - 10.3390/cells13020156 [doi]
PST - epublish
SO  - Cells. 2024 Jan 15;13(2):156. doi: 10.3390/cells13020156.