PMID- 38248689
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 2079-4983 (Print)
IS  - 2079-4983 (Electronic)
IS  - 2079-4983 (Linking)
VI  - 15
IP  - 1
DP  - 2024 Jan 14
TI  - Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone 
      Scaffold Materials.
LID - 10.3390/jfb15010022 [doi]
LID - 22
AB  - Nano-hydroxyapatite (HAp) is an ideal material in the field of biomedicine due to 
      its good biocompatibility and bioactivity. However, a significant drawback of 
      pure HAp materials is their inferior mechanical properties. Therefore, in this 
      rigorous investigation, the optimal calcium-to-phosphorus ratio for the synthesis 
      of HAp was meticulously delineated, followed by its nuanced modification using 
      KH550 (gamma-aminopropyltriethoxysilane). This was further amalgamated with 
      polycaprolactone (PCL) with the aim of providing a superior material alternative 
      within the domain of bone scaffold materials. The post-modified HAp demonstrated 
      enhanced interfacial compatibility with PCL, bestowing the composite with 
      superior mechanical characteristics, notably a peak bending strength of 6.38 +/- 
      0.037 MPa and a tensile strength of 3.71 +/- 0.040 MPa. Scanning electron 
      microscope (SEM) imagery revealed an intriguing characteristic of the composite: 
      an initial ascension in porosity upon HAp integration, subsequently followed by a 
      decline. Beyond this, the composite not only exhibited stellar auto-degradation 
      prowess but also realized a sustained release cycle of 24 h, markedly optimizing 
      drug utility efficiency. A kinetic model for drug dispensation was developed, 
      positing an adherence to a pseudo-second-order kinetic principle. In tandem, 
      through the formulation of an intra-particle diffusion model, the diffusion 
      mechanisms pre- and post-modification were deeply probed. Cytotoxicity assays 
      underscored the composite's exemplary biocompatibility. Such findings accentuate 
      the vast potential of the modified HAp-PCL composite in bone tissue engineering, 
      heralding a novel and efficacious avenue for impending bone defect amelioration.
FAU - Hong, Ziyi
AU  - Hong Z
AD  - Department for Materials Science and Engineering, East China Jiao Tong 
      University, Nanchang 330013, China.
FAU - Wang, Shaohui
AU  - Wang S
AD  - Department for Materials Science and Engineering, East China Jiao Tong 
      University, Nanchang 330013, China.
FAU - Liu, Fengyu
AU  - Liu F
AD  - Department for Materials Science and Engineering, East China Jiao Tong 
      University, Nanchang 330013, China.
LA  - eng
GR  - GJJ2200601/Key Science and Technology Projects of Jiangxi Provincial Department 
      of Education/
PT  - Journal Article
DEP - 20240114
PL  - Switzerland
TA  - J Funct Biomater
JT  - Journal of functional biomaterials
JID - 101570734
PMC - PMC10817442
OTO - NOTNLM
OT  - PCL
OT  - artificial bone scaffold
OT  - solvothermal reaction method
OT  - tubular HAp
OT  - gamma-aminopropyltriethoxysilane (KH550)
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/22 06:43
MHDA- 2024/01/22 06:44
PMCR- 2024/01/14
CRDT- 2024/01/22 04:43
PHST- 2023/12/11 00:00 [received]
PHST- 2024/01/08 00:00 [revised]
PHST- 2024/01/10 00:00 [accepted]
PHST- 2024/01/22 06:44 [medline]
PHST- 2024/01/22 06:43 [pubmed]
PHST- 2024/01/22 04:43 [entrez]
PHST- 2024/01/14 00:00 [pmc-release]
AID - jfb15010022 [pii]
AID - jfb-15-00022 [pii]
AID - 10.3390/jfb15010022 [doi]
PST - epublish
SO  - J Funct Biomater. 2024 Jan 14;15(1):22. doi: 10.3390/jfb15010022.