PMID- 38248799
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Jan 16
TI  - Analysis of Thyroid Function in ANCA-Associated Vasculitis Patients with Renal 
      Injury.
LID - 10.3390/jpm14010099 [doi]
LID - 99
AB  - BACKGROUND: Previous studies indicated common thyroid dysfunction in various 
      kidney diseases. This study aimed to investigate the thyroid function in patients 
      with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) with renal 
      injury. METHODS: Briefly, 174 patients diagnosed as having AAV with renal injury 
      and without previous thyroid disease history were included in the retrospective 
      and prospective study. The clinical parameters were collected and compared 
      between different groups. RESULTS: Of the patients included, 24 exhibited normal 
      thyroid function, while 150 had thyroid dysfunction, including 55 (36.67%) with 
      hypothyroidism. Those AAV patients with thyroid dysfunction showed different 
      clinical parameters from those with normal thyroid function. The patients were 
      followed up for a median of 68.6 (64.3; 72.8) months. Those with thyroid 
      dysfunction were more prone to progressing to dialysis dependence compared to the 
      group with normal thyroid function. Logistic regression analysis showed advanced 
      age and decreased albumin as independent risk factors for thyroid dysfunction in 
      patients with AAV. Survival analysis and multivariate Cox regression analysis 
      showed that thyroid dysfunction was a risk factor for AAV patients with renal 
      injury to progress to the endpoint of dialysis dependence. CONCLUSION: Thyroid 
      dysfunction, predominantly hypothyroidism, was commonly complicated in AAV 
      patients with renal injury. AAV patients with thyroid dysfunction were presented 
      with different clinical parameters and more prone to progressing to dialysis 
      dependence compared to those with normal thyroid function.
FAU - Yu, Wenhui
AU  - Yu W
AD  - Department of Nephrology, Kidney Research Institute, West China Hospital of 
      Sichuan University, Chengdu 610041, China.
FAU - Wang, Yuelan
AU  - Wang Y
AD  - Renal Division, Department of Medicine, Chengdu Second People's Hospital, Chengdu 
      610041, China.
FAU - Ma, Liang
AU  - Ma L
AUID- ORCID: 0000-0001-8327-7969
AD  - Department of Nephrology, Kidney Research Institute, West China Hospital of 
      Sichuan University, Chengdu 610041, China.
FAU - Gou, Shenju
AU  - Gou S
AUID- ORCID: 0000-0002-0151-5036
AD  - Department of Nephrology, Kidney Research Institute, West China Hospital of 
      Sichuan University, Chengdu 610041, China.
AD  - Department of Nephrology, West China Tianfu Hospital of Sichuan University, 
      Chengdu 610200, China.
FAU - Fu, Ping
AU  - Fu P
AD  - Department of Nephrology, Kidney Research Institute, West China Hospital of 
      Sichuan University, Chengdu 610041, China.
LA  - eng
GR  - Sichuan Science and Technology Program/Sichuan Science and Technology Program/
PT  - Journal Article
DEP - 20240116
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC10817250
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibody
OT  - renal injury
OT  - thyroid dysfunction
OT  - vasculitis
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/22 06:43
MHDA- 2024/01/22 06:44
PMCR- 2024/01/16
CRDT- 2024/01/22 04:44
PHST- 2023/12/04 00:00 [received]
PHST- 2024/01/08 00:00 [revised]
PHST- 2024/01/12 00:00 [accepted]
PHST- 2024/01/22 06:44 [medline]
PHST- 2024/01/22 06:43 [pubmed]
PHST- 2024/01/22 04:44 [entrez]
PHST- 2024/01/16 00:00 [pmc-release]
AID - jpm14010099 [pii]
AID - jpm-14-00099 [pii]
AID - 10.3390/jpm14010099 [doi]
PST - epublish
SO  - J Pers Med. 2024 Jan 16;14(1):99. doi: 10.3390/jpm14010099.