PMID- 38248868
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2221-3759 (Electronic)
IS  - 2221-3759 (Linking)
VI  - 12
IP  - 1
DP  - 2024 Jan 5
TI  - Established and Evolving Roles of the Multifunctional Non-POU Domain-Containing 
      Octamer-Binding Protein (NonO) and Splicing Factor Proline- and Glutamine-Rich 
      (SFPQ).
LID - 10.3390/jdb12010003 [doi]
LID - 3
AB  - It has been more than three decades since the discovery of multifunctional 
      factors, the Non-POU-Domain-Containing Octamer-Binding Protein, NonO, and the 
      Splicing Factor Proline- and Glutamine-Rich, SFPQ. Some of their functions, 
      including their participation in transcriptional and posttranscriptional 
      regulation as well as their contribution to paraspeckle subnuclear body 
      organization, have been well documented. In this review, we focus on several 
      other established roles of NonO and SFPQ, including their participation in the 
      cell cycle, nonhomologous end-joining (NHEJ), homologous recombination (HR), 
      telomere stability, childhood birth defects and cancer. In each of these 
      contexts, the absence or malfunction of either or both NonO and SFPQ leads to 
      either genome instability, tumor development or mental impairment.
FAU - Yu, Danyang
AU  - Yu D
AD  - Department of Biology, New York University in Shanghai, Shanghai 200122, China.
FAU - Huang, Ching-Jung
AU  - Huang CJ
AD  - Department of Biology, New York University in Shanghai, Shanghai 200122, China.
FAU - Tucker, Haley O
AU  - Tucker HO
AUID- ORCID: 0000-0001-7735-2862
AD  - Molecular Biosciences, Institute for Cellular and Molecular Biology, University 
      of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
LA  - eng
GR  - R01 CA031534/CA/NCI NIH HHS/United States
GR  - R01CA31534/NH/NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20240105
PL  - Switzerland
TA  - J Dev Biol
JT  - Journal of developmental biology
JID - 101613409
PMC - PMC10801543
OTO - NOTNLM
OT  - ATR/ATM
OT  - DNA damage response
OT  - NonO/p54nrb
OT  - SFPQ/PSF
OT  - birth defects
OT  - cancer
OT  - cell cycle
OT  - checkpoint control
COIS- These authors declare no conflicts of interest.
EDAT- 2024/01/22 06:43
MHDA- 2024/01/22 06:44
PMCR- 2024/01/05
CRDT- 2024/01/22 04:44
PHST- 2023/10/16 00:00 [received]
PHST- 2023/12/25 00:00 [revised]
PHST- 2023/12/28 00:00 [accepted]
PHST- 2024/01/22 06:44 [medline]
PHST- 2024/01/22 06:43 [pubmed]
PHST- 2024/01/22 04:44 [entrez]
PHST- 2024/01/05 00:00 [pmc-release]
AID - jdb12010003 [pii]
AID - jdb-12-00003 [pii]
AID - 10.3390/jdb12010003 [doi]
PST - epublish
SO  - J Dev Biol. 2024 Jan 5;12(1):3. doi: 10.3390/jdb12010003.