PMID- 38250493 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240123 IS - 2452-2325 (Print) IS - 2452-2325 (Electronic) IS - 2452-2325 (Linking) VI - 35 IP - 2 DP - 2023 Apr-Jun TI - Peripapillary Retinal Nerve Fiber Layer Thickness and its Ocular and Systemic Determinants in an Elderly Population: A Population-Based Study. PG - 135-144 LID - 10.4103/joco.joco_49_23 [doi] AB - PURPOSE: To determine the distribution, ocular, and systemic determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) using spectral-domain optical coherence tomography (SD-OCT) in an elderly population. METHODS: This report is a part of the Tehran Geriatric Eye Study, a population-based cross-sectional study conducted in Tehran, the capital of Iran. The study population was all residents aged 60 years and above in Tehran. The sampling was performed using a multi-stage stratified random cluster sampling method. All study participants underwent ocular examination (including measurement of visual acuity, objective and subjective refraction, and slit-lamp biomicroscopy), anterior segment imaging using Pentacam HR, and ocular biometry using IOLMaster 500. The OCT imaging was performed for a random subsample (1307 individuals) using Spectralis SD-OCT. RESULTS: Two thousand two hundred and forty-six eyes of 1189 individuals were analyzed for this report. Of these, 691 (58.1%) were female, and the mean age of the participants was 67.3 +/- 5.9 years (60-94 years). The mean overall pRNFLT was 98.6 mu (95% confidence interval [CI]: 98.0-99.3). There was a statistically significant difference in pRNFLT between different quadrants; the highest and lowest mean pRNFLT was related to inferior and temporal quadrants, respectively (P < 0.001). The multiple generalized estimating equation model showed that older age (coefficient: -0.15 [95% CI: -0.24 to -0.06], P = 0.001), diabetes (coefficient: -1.69 [95% CI: -2.82 to -0.55], P = 0.004), and longer axial length (coefficient: -0.52 [95% CI: -0.83 to -0.22], P < 0.001) were significantly associated with a decreased overall pRNFLT. Higher body mass index was significantly related to an increased overall pRNFLT (coefficient: 0.19 [95% CI: 0.07 to 0.30], P = 0.002). CONCLUSIONS: The results of the present study can be used as a reference database for pRNFLT in the elderly population. Considering ocular and systemic determinants of pRNFLT is necessary for correct clinical interpretation of this parameter. CI - Copyright: (c) 2023 Journal of Current Ophthalmology. FAU - Rafati, Shokoofeh AU - Rafati S AD - Rehabilitation Research Center, Department of Optometry, Iran University of Medical Sciences, Tehran, Iran. FAU - Khabazkhoob, Mehdi AU - Khabazkhoob M AD - Department of Basic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mortazavi, Mehdi AU - Mortazavi M AD - Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran. FAU - Asharlous, Amir AU - Asharlous A AD - Rehabilitation Research Center, Department of Optometry, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20231221 PL - India TA - J Curr Ophthalmol JT - Journal of current ophthalmology JID - 101678509 PMC - PMC10795815 OTO - NOTNLM OT - Elderly population OT - Ocular determinants OT - Peripapillary retinal nerve fiber layer thickness OT - Population-based study OT - Systemic determinants COIS- There are no conflicts of interest. EDAT- 2024/01/22 06:43 MHDA- 2024/01/22 06:44 PMCR- 2023/12/21 CRDT- 2024/01/22 05:23 PHST- 2023/02/26 00:00 [received] PHST- 2023/04/24 00:00 [revised] PHST- 2023/04/24 00:00 [accepted] PHST- 2024/01/22 06:44 [medline] PHST- 2024/01/22 06:43 [pubmed] PHST- 2024/01/22 05:23 [entrez] PHST- 2023/12/21 00:00 [pmc-release] AID - JCO-35-135 [pii] AID - 10.4103/joco.joco_49_23 [doi] PST - epublish SO - J Curr Ophthalmol. 2023 Dec 21;35(2):135-144. doi: 10.4103/joco.joco_49_23. eCollection 2023 Apr-Jun.