PMID- 38250610 OWN - NLM STAT- MEDLINE DCOM- 20240123 LR - 20240202 IS - 1449-1907 (Electronic) IS - 1449-1907 (Linking) VI - 21 IP - 3 DP - 2024 TI - Transcription factor 21 rs12190287 polymorphism is related to stable angina and ST elevation myocardial infarction in a Chinese Population. PG - 483-491 LID - 10.7150/ijms.89901 [doi] AB - Background: Transcription factor 21 (TCF21, epicardin, capsuling, pod-1) is expressed in the epicardium and is involved in the regulation of cell fate and differentiation via epithelial-mesenchymal transformation during development of the heart. In addition, TCF21 can suppress the differentiation of epicardial cells into vascular smooth muscle cells and promote cardiac fibroblast development. This study aimed to explore whether TCF21 gene (12190287G/C) variants affect coronary artery disease risk. Methods: We enrolled 381 patients who had stable angina, 138 with ST elevation myocardial infarction (STEMI), and 276 healthy subjects. Genotyping of rs12190287 of the TCF21 gene was performed. Results: Higher frequencies of the CC genotype were found in the patients with stable angina/STEMI than in the healthy controls. After adjusting for diabetes mellitus, hypertension, age, sex, smoking, body mass index and hyperlipidemia, the patients with the CC genotype of the TCF21 gene were associated with 2.49- and 9.19-fold increased risks of stable angina and STEMI, respectively, compared to the patients with the GG genotype. Furthermore, TCF21 CC genotypes showed positive correlations with both stable angina and STEMI, whereas TCF21 GG genotypes exhibited a negative correlation with STEMI. Moreover, the stable angina and STEMI patients with the CC genotype had significantly elevated high-sensitivity C-reactive protein levels than those with the GG genotype. In addition, significant associations were found between type 2 diabetes mellitus, hypertension, and hyperlipidemia with TCF21 gene polymorphisms (p for trend < 0.05). Conclusion: TCF21 gene polymorphisms may increase susceptibility to stable angina and STEMI. CI - (c) The author(s). FAU - Yu, Teng-Hung AU - Yu TH AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Lee, Thung-Lip AU - Lee TL AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. AD - School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Tsai, I-Ting AU - Tsai IT AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Department of Emergency, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. FAU - Hsuan, Chin-Feng AU - Hsuan CF AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, I-Shou University, Kaohsiung 807066, Taiwan. FAU - Wang, Chao-Ping AU - Wang CP AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. AD - School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. FAU - Lu, Yung-Chuan AU - Lu YC AD - School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. FAU - Tang, Wei-Hua AU - Tang WH AD - Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Yuli Branch, Hualien 98142 Taiwan. AD - Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304 Taiwan. FAU - Wei, Ching-Ting AU - Wei CT AD - Division of General Surgery, Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. AD - The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung 82445 Taiwan. FAU - Chung, Fu-Mei AU - Chung FM AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. FAU - Lee, Yau-Jiunn AU - Lee YJ AD - Lee's Endocrinologic Clinic, Pingtung 90000 Taiwan. FAU - Wu, Cheng-Ching AU - Wu CC AD - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445 Taiwan. AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan. AD - Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, I-Shou University, Kaohsiung 82445 Taiwan. LA - eng PT - Journal Article DEP - 20240101 PL - Australia TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 0 (TCF21 protein, human) RN - 0 (Basic Helix-Loop-Helix Transcription Factors) SB - IM MH - Humans MH - *Angina, Stable/genetics MH - *ST Elevation Myocardial Infarction/genetics MH - *Diabetes Mellitus, Type 2 MH - *Hypertension MH - *Hyperlipidemias MH - China MH - Basic Helix-Loop-Helix Transcription Factors/genetics PMC - PMC10797673 OTO - NOTNLM OT - ST elevation myocardial infarction OT - polymorphism OT - stable angina OT - transcription factor 21 COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2024/01/22 06:42 MHDA- 2024/01/23 06:43 PMCR- 2024/01/01 CRDT- 2024/01/22 05:27 PHST- 2023/09/06 00:00 [received] PHST- 2023/12/20 00:00 [accepted] PHST- 2024/01/23 06:43 [medline] PHST- 2024/01/22 06:42 [pubmed] PHST- 2024/01/22 05:27 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - ijmsv21p0483 [pii] AID - 10.7150/ijms.89901 [doi] PST - epublish SO - Int J Med Sci. 2024 Jan 1;21(3):483-491. doi: 10.7150/ijms.89901. eCollection 2024.