PMID- 38251425
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240410
IS  - 1365-3040 (Electronic)
IS  - 0140-7791 (Linking)
VI  - 47
IP  - 5
DP  - 2024 May
TI  - PHYTOCHROME A controls the DNA damage response and cell death tolerance within 
      the Arabidopsis root meristem.
PG  - 1513-1525
LID - 10.1111/pce.14831 [doi]
AB  - The DNA damage response avoids mutations into dividing cells. Here, we analysed 
      the role of photoreceptors on the restriction of root growth imposed by genotoxic 
      agents and its relationship with cell viability and performance of meristems. 
      Comparison of root growth of Arabidopsis WT, phyA-211, phyB-9, and phyA-211phyB-9 
      double mutants unveiled a critical role for phytochrome A (PhyA) in protecting 
      roots from genotoxic stress, regeneration and cell replenishment in the 
      meristematic zone. PhyA was located on primary root tips, where it influences 
      genes related to the repair of DNA, including ERF115 and RAD51. Interestingly, 
      phyA-211 mutants treated with zeocin failed to induce the expression of the 
      repressor of cell cycle MYB3R3, which correlated with expression of the mitotic 
      cyclin CycB1, suggesting that PhyA is required for safeguarding the DNA integrity 
      during cell division. Moreover, the growth of the primary roots of PhyA 
      downstream component HY5 and root growth analyses in darkness suggest that cell 
      viability and DNA damage responses within root meristems may act independently 
      from light and photomorphogenesis. These data support novel roles for PhyA as a 
      key player for stem cell niche maintenance and DNA damage responses, which are 
      critical for proper root growth.
CI  - (c) 2024 John Wiley & Sons Ltd.
FAU - Huerta-Venegas, Pedro Ivan
AU  - Huerta-Venegas PI
AUID- ORCID: 0000-0002-9053-8546
AD  - Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San 
      Nicolas de Hidalgo, Morelia, Michoacan, Mexico.
FAU - Raya-Gonzalez, Javier
AU  - Raya-Gonzalez J
AUID- ORCID: 0000-0002-6685-5090
AD  - Facultad de Quimico Farmacobiologia, Universidad Michoacana de San Nicolas de 
      Hidalgo, Morelia, Michoacan, Mexico.
FAU - Ruiz-Herrera, Leon Francisco
AU  - Ruiz-Herrera LF
AUID- ORCID: 0000-0002-0762-6749
AD  - Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San 
      Nicolas de Hidalgo, Morelia, Michoacan, Mexico.
FAU - Lopez-Bucio, Jose
AU  - Lopez-Bucio J
AUID- ORCID: 0000-0002-4849-5212
AD  - Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San 
      Nicolas de Hidalgo, Morelia, Michoacan, Mexico.
LA  - eng
GR  - FORDECYT-PRONACES/376120/2020/
GR  - SEP-CONACYT A1-S-34769/
GR  - Secretaria de Educacion Publica/
PT  - Journal Article
DEP - 20240122
PL  - United States
TA  - Plant Cell Environ
JT  - Plant, cell & environment
JID - 9309004
RN  - 0 (Arabidopsis Proteins)
RN  - 9007-49-2 (DNA)
RN  - 11121-56-5 (Phytochrome)
RN  - 0 (Phytochrome A)
RN  - 136250-22-1 (Phytochrome B)
RN  - 0 (PHYA protein, Arabidopsis)
SB  - IM
MH  - *Arabidopsis/metabolism
MH  - *Arabidopsis Proteins/genetics/metabolism
MH  - Cell Death
MH  - DNA/metabolism
MH  - DNA Repair/genetics
MH  - Light
MH  - Meristem/genetics/metabolism
MH  - Mutation
MH  - *Phytochrome/metabolism
MH  - Phytochrome A/genetics/metabolism
MH  - Phytochrome B/metabolism
OTO - NOTNLM
OT  - Arabidopsis root
OT  - DNA damage
OT  - photoreceptors
OT  - phytochrome A
OT  - programmed cell death
OT  - stem cell niche
EDAT- 2024/01/22 06:42
MHDA- 2024/04/08 06:43
CRDT- 2024/01/22 05:47
PHST- 2023/11/21 00:00 [revised]
PHST- 2022/06/30 00:00 [received]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/01/22 06:42 [pubmed]
PHST- 2024/01/22 05:47 [entrez]
AID - 10.1111/pce.14831 [doi]
PST - ppublish
SO  - Plant Cell Environ. 2024 May;47(5):1513-1525. doi: 10.1111/pce.14831. Epub 2024 
      Jan 22.