PMID- 38254615
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 13
IP  - 2
DP  - 2024 Jan 18
TI  - Dissipation, Residue and Human Dietary Risk Assessment of Pyraclostrobin and 
      Cyazofamid in Grapes Using an HPLC-UV Detector.
LID - 10.3390/foods13020314 [doi]
LID - 314
AB  - Pyraclostrobin is a new broad-spectrum methoxyacrylic acid fungicide. Cyazofamid 
      is a new selective foliar spray acaricide. Here, we studied the degradation rate 
      and final residues of pyraclostrobin and cyazofamid in grape and evaluated their 
      dietary risk to consumers. The average recoveries of pyraclostrobin ether ester, 
      cyazofamid and cyazofamid metabolite (CCIM) in grapes were 84-94%, 92-98% and 
      99-104%, respectively. The relative standard deviations (RSDs) were 6.0-20.3%, 
      2.4-10.5% and 1.3-4.0%, respectively, and the LOQs were all 0.05 mg/kg. The 
      digestion dynamics of the experimental sites were in accordance with the 
      first-order kinetic equation. The degradation half-lives of pyraclostrobin ether 
      ester and cyazofamid were 17.8 d-28.9 d and 4.3 d-7.8 d, respectively. The final 
      residues of pyraclostrobin ether ester, cyazofamid and CCIM in grapes were 
      <0.05-1.88 mg/kg, <0.05-0.31 mg/kg and <0.05-0.47 mg/kg, respectively. Using 
      probability models, the total chronic risk values for pyraclostrobin and 
      cyazofamid were calculated to be 0.112-189.617% and 0.021-1.714%, respectively. 
      The results of the contribution analysis indicate that pyraclostrobin poses a 
      much greater risk to Chinese consumers than cyazofamid, especially to children 
      and adolescents, who have a significantly greater risk than adults. This suggests 
      that more consideration should be given to the cumulative risk of compounds for 
      vulnerable groups in the future.
FAU - Zhao, Peiying
AU  - Zhao P
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
FAU - Liu, Rong
AU  - Liu R
AUID- ORCID: 0000-0001-7990-8051
AD  - Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 
      100081, China.
FAU - Yuan, Longfei
AU  - Yuan L
AUID- ORCID: 0000-0001-8993-3285
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
LA  - eng
GR  - 31501667/National Natural Science Foundation of China/
GR  - 2016YFD0201207/National Key Research and Development Program of China/
PT  - Journal Article
DEP - 20240118
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC10814842
OTO - NOTNLM
OT  - CCIM
OT  - cyazofamid
OT  - dietary risk assessment
OT  - dissipation behavior
OT  - grape
OT  - pyraclostrobin
OT  - residue
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/23 06:43
MHDA- 2024/01/23 06:44
PMCR- 2024/01/18
CRDT- 2024/01/23 01:03
PHST- 2023/11/30 00:00 [received]
PHST- 2024/01/12 00:00 [revised]
PHST- 2024/01/13 00:00 [accepted]
PHST- 2024/01/23 06:44 [medline]
PHST- 2024/01/23 06:43 [pubmed]
PHST- 2024/01/23 01:03 [entrez]
PHST- 2024/01/18 00:00 [pmc-release]
AID - foods13020314 [pii]
AID - foods-13-00314 [pii]
AID - 10.3390/foods13020314 [doi]
PST - epublish
SO  - Foods. 2024 Jan 18;13(2):314. doi: 10.3390/foods13020314.