PMID- 38255389
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 11
IP  - 1
DP  - 2024 Jan 9
TI  - Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone 
      Disease at 2 Years of Age.
LID - 10.3390/children11010076 [doi]
LID - 76
AB  - Metabolic bone disease (MBD) predominantly affects preterm infants, particularly 
      very-low-birth-weight (VLBW) infants weighing <1500 g. However, there are limited 
      reports on MBD and neurodevelopmental outcomes. This study aimed to analyze the 
      risk factors for MBD and understand its impact on neurodevelopmental outcomes at 
      2 years of corrected age. Overall, 749 VLBW infants weighing <1350 g at birth 
      were enrolled. Exclusion criteria were major congenital abnormalities, 
      chromosomal abnormalities, and loss of follow-up on the Bayley Scales of Infant 
      Development, Third Edition (BSID-III) test at 24 months of corrected age. Infants 
      were retrospectively assessed by a trained case manager using the BSID-III test 
      at 6, 12, and 24 months old. Infants were categorized as with or without MBD 
      according to radiographic signs. Of those enrolled, 97 VLBW infants were 
      diagnosed with MBD, compared to 362 VLBW infants without MBD. The proportion of 
      infants that completed three follow-ups was 86%. At the assessment at 2 years of 
      age, infants with MBD had lower and more significant differences in motor, 
      language, and cognitive composites. MBD is associated with poor 
      neurodevelopmental outcomes in cognitive, motor, and language composites for VLBW 
      infants at 24 months of corrected age.
FAU - Chen, Yu-Wen
AU  - Chen YW
AUID- ORCID: 0009-0000-7250-5022
AD  - Department of Neonatology, Changhua Christian Children's Hospital, No. 320, 
      Xuguang Road, Changhua City 500010, Taiwan.
FAU - Chang, Yu-Jun
AU  - Chang YJ
AUID- ORCID: 0000-0002-1433-6002
AD  - Big Data Center, Changhua Christian Hospital, No. 135, Nanxiao Street, Changhua 
      City 500209, Taiwan.
FAU - Chen, Lih-Ju
AU  - Chen LJ
AD  - Department of Neonatology, Changhua Christian Children's Hospital, No. 320, 
      Xuguang Road, Changhua City 500010, Taiwan.
FAU - Lee, Cheng-Han
AU  - Lee CH
AD  - Department of Neonatology, Changhua Christian Children's Hospital, No. 320, 
      Xuguang Road, Changhua City 500010, Taiwan.
FAU - Hsiao, Chien-Chou
AU  - Hsiao CC
AUID- ORCID: 0000-0002-4523-5300
AD  - Department of Neonatology, Changhua Christian Children's Hospital, No. 320, 
      Xuguang Road, Changhua City 500010, Taiwan.
AD  - Department of Post-Baccalaureate Medicine, College of Medicine, National Chung 
      Hsing University, No. 145, Xingda Road, South District, Taichung City 402202, 
      Taiwan.
FAU - Chen, Jia-Yuh
AU  - Chen JY
AD  - Department of Neonatology, Changhua Christian Children's Hospital, No. 320, 
      Xuguang Road, Changhua City 500010, Taiwan.
AD  - Department of Post-Baccalaureate Medicine, College of Medicine, National Chung 
      Hsing University, No. 145, Xingda Road, South District, Taichung City 402202, 
      Taiwan.
FAU - Chen, Hsiao-Neng
AU  - Chen HN
AD  - Department of Neonatology, Changhua Christian Children's Hospital, No. 320, 
      Xuguang Road, Changhua City 500010, Taiwan.
AD  - School of Medicine, Chung-Sun Medical University, No. 110, Sec. 1, Jianguo N. 
      Road, South District, Taichung City 402306, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20240109
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10814392
OTO - NOTNLM
OT  - Bayley Scales of Infant Development-III
OT  - metabolic bone disease
OT  - neurodevelopmental outcomes
OT  - risk factors
OT  - very-low-birth-weight infants
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/23 06:43
MHDA- 2024/01/23 06:44
PMCR- 2024/01/09
CRDT- 2024/01/23 01:07
PHST- 2023/12/04 00:00 [received]
PHST- 2024/01/04 00:00 [revised]
PHST- 2024/01/06 00:00 [accepted]
PHST- 2024/01/23 06:44 [medline]
PHST- 2024/01/23 06:43 [pubmed]
PHST- 2024/01/23 01:07 [entrez]
PHST- 2024/01/09 00:00 [pmc-release]
AID - children11010076 [pii]
AID - children-11-00076 [pii]
AID - 10.3390/children11010076 [doi]
PST - epublish
SO  - Children (Basel). 2024 Jan 9;11(1):76. doi: 10.3390/children11010076.