PMID- 38255541
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240129
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 17
IP  - 2
DP  - 2024 Jan 11
TI  - Very Large Pore Mesoporous Bioactive Silicate Glasses: Comparison of Behavior 
      toward Classical Mesoporous Bioactive Glasses in Terms of Drug Loading/Release 
      and Bioactivity.
LID - 10.3390/ma17020373 [doi]
LID - 373
AB  - Considering the increase in patients who suffer from osteoporosis and the bone 
      defects that occur in these patients, bone tissue regeneration is a promising 
      option to solve this problem. To achieve a synergistic effect between the 
      synthesis of a proper structure and bioactive/pharmaceutical activity, ions with 
      a physiological effect can be added to silica structures, such as Ca(2+), thanks 
      to its bioactive behavior, and Ga(3+) for its antibacterial and anticancer 
      action. In this work, the synthesis of large pore mesoporous silica (LPMS), 
      potential bioactive glasses containing Ca(2+) and Ga(3+), has been studied. 
      Corresponding structures, in terms of composition, have been synthesized 
      following the Sol-Gel EISA (Evaporation Induced Self-Assembly) process (obtaining 
      Classical Mesoporous Silica, MS). Pore structure characterization of LPMSs and 
      MSs has been performed using N(2) adsorption/desorption and Hg-porosimetry, 
      showing the presence of pores for LPMSs in the range of 20-60 and 200-600 nm. 
      Nisin, a polycyclic antibacterial peptide, has been used for load tests. The load 
      and release tests performed highlight a higher loading and releasing, doubled for 
      LPMSs if compared to MSs. To confirm the maintenance of the structure of LPMSs 
      and their mechanical strength and resistance, scanning electron microscopy images 
      were acquired before and after release tests. Ca and Ga release in SBF has been 
      studied through inductively coupled plasma-optical emission spectroscopy 
      (ICP-OES), showing a particularly high release of these ions performed with 
      LPMSs. The bioactive behavior of Ca-containing structures has been confirmed 
      using FT-IR (Fourier-transform infrared spectroscopy), SEM-EDS (Scanning Electron 
      Microscope-Energy Dispersive Spectroscopy), and X-ray powder diffraction (XRDP). 
      In conclusion, LPMSs showed better loading and releasing properties compared with 
      classical MS and better release in terms of active ions. In addition, it has also 
      been demonstrated that LPMSs have bioactive behavior (a well-known characteristic 
      of MSs).
FAU - Carrozza, Debora
AU  - Carrozza D
AUID- ORCID: 0000-0001-6998-0922
AD  - Department of Chemical and Geological Sciences, University of Modena and Reggio 
      Emilia, Via G. Campi 103, 41125 Modena, Italy.
FAU - Ferrari, Erika
AU  - Ferrari E
AUID- ORCID: 0000-0001-7627-2502
AD  - Department of Chemical and Geological Sciences, University of Modena and Reggio 
      Emilia, Via G. Campi 103, 41125 Modena, Italy.
FAU - Malavasi, Gianluca
AU  - Malavasi G
AUID- ORCID: 0000-0002-4557-8135
AD  - Department of Chemical and Geological Sciences, University of Modena and Reggio 
      Emilia, Via G. Campi 103, 41125 Modena, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240111
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC10820009
OTO - NOTNLM
OT  - Ga-containing glasses
OT  - bioactive glasses
OT  - large pore mesoporous silica
OT  - nisin
OT  - pharmaceutical peptides
OT  - porous biomaterials
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/23 06:43
MHDA- 2024/01/23 06:44
PMCR- 2024/01/11
CRDT- 2024/01/23 01:08
PHST- 2023/12/01 00:00 [received]
PHST- 2023/12/27 00:00 [revised]
PHST- 2024/01/08 00:00 [accepted]
PHST- 2024/01/23 06:44 [medline]
PHST- 2024/01/23 06:43 [pubmed]
PHST- 2024/01/23 01:08 [entrez]
PHST- 2024/01/11 00:00 [pmc-release]
AID - ma17020373 [pii]
AID - materials-17-00373 [pii]
AID - 10.3390/ma17020373 [doi]
PST - epublish
SO  - Materials (Basel). 2024 Jan 11;17(2):373. doi: 10.3390/ma17020373.