PMID- 38255953
OWN - NLM
STAT- MEDLINE
DCOM- 20240201
LR  - 20240201
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 2
DP  - 2024 Jan 10
TI  - HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis.
LID - 10.3390/ijms25020882 [doi]
LID - 882
AB  - Studies concerning the genetic background of IgA vasculitis (IgAV), a 
      small-vessel vasculitis occurring predominantly in childhood, have confirmed that 
      the HLA-DRB1 gene showed a strong association with disease susceptibility. The 
      objective was to investigate human leukocyte antigen (HLA) polymorphisms among 
      Croatian patients with IgAV and their influence on disease susceptibility and 
      clinical heterogeneity. Thus, 130 children with IgAV and 202 unrelated healthy 
      individuals were enrolled in the study. Genomic DNA was extracted from whole 
      peripheral blood, and HLA-A, -B, -DRB1 and -DQB1 gene polymorphism analysis was 
      performed. HLA-A*03 (21.4% vs. 12.38%, p = 0.0092), HLA-B*37 (2.9% vs. 0.2%, p = 
      0.0054) and HLA-DRB1*12 (3.1% vs. 0.7%, p = 0.0216) alleles were significantly 
      more frequent in IgAV patients than in controls. High-resolution typing revealed 
      significantly higher frequency of HLA-DRB1*10:01 and -DRB1*11:03 among IgAV 
      patients with gastrointestinal manifestations of the disease in comparison to 
      controls (p = 0.0021 and p = 0.0301, respectively), while HLA-DRB1*14:01P 
      occurred significantly more often in the group of patients who developed 
      nephritis during the course of the disease (17.5% vs. 4.5%, p = 0.0006). Our 
      results demonstrated that there is an association of HLA-A*03, HLA-B*37 and 
      HLA-DRB1*12 alleles with susceptibility to IgAV in the examined Croatian 
      pediatric population. Studies which aim to determine the HLA profile may 
      contribute to the elucidation of the genetic background of autoimmune diseases, 
      including IgAV.
FAU - Held, Martina
AU  - Held M
AUID- ORCID: 0000-0002-4925-8948
AD  - Department of Pediatrics, University Hospital Centre Zagreb, University of Zagreb 
      School of Medicine, 10000 Zagreb, Croatia.
FAU - Stingl Jankovic, Katarina
AU  - Stingl Jankovic K
AD  - Tissue Typing Centre, Clinical Department for Transfusion Medicine and 
      Transplantation Biology, University Hospital Centre Zagreb, 10000 Zagreb, 
      Croatia.
FAU - Sestan, Mario
AU  - Sestan M
AUID- ORCID: 0000-0003-1092-6491
AD  - Department of Pediatrics, University Hospital Centre Zagreb, University of Zagreb 
      School of Medicine, 10000 Zagreb, Croatia.
FAU - Sapina, Matej
AU  - Sapina M
AD  - Department of Pediatrics, University Hospital Centre Osijek, Josip Juraj 
      Strossmayer University of Osijek, Medical Faculty Osijek, 31000 Osijek, Croatia.
FAU - Kifer, Nastasia
AU  - Kifer N
AD  - Department of Pediatrics, University Hospital Centre Zagreb, University of Zagreb 
      School of Medicine, 10000 Zagreb, Croatia.
FAU - Srsen, Sasa
AU  - Srsen S
AUID- ORCID: 0000-0001-6555-2613
AD  - Department of Pediatrics, University of Split School of Medicine, University 
      Hospital Centre Split, 21000 Split, Croatia.
FAU - Frkovic, Marijan
AU  - Frkovic M
AUID- ORCID: 0000-0002-1520-3375
AD  - Department of Pediatrics, University Hospital Centre Zagreb, University of Zagreb 
      School of Medicine, 10000 Zagreb, Croatia.
FAU - Gagro, Alenka
AU  - Gagro A
AD  - Children's Hospital Zagreb, Medical Faculty Osijek, Josip Juraj Strossmayer 
      University of Osijek, 10000 Zagreb, Croatia.
FAU - Grubic, Zorana
AU  - Grubic Z
AD  - Tissue Typing Centre, Clinical Department for Transfusion Medicine and 
      Transplantation Biology, University Hospital Centre Zagreb, 10000 Zagreb, 
      Croatia.
FAU - Jelusic, Marija
AU  - Jelusic M
AUID- ORCID: 0000-0002-1728-4260
AD  - Department of Pediatrics, University Hospital Centre Zagreb, University of Zagreb 
      School of Medicine, 10000 Zagreb, Croatia.
LA  - eng
GR  - IP-2019-04-8822/Croatian Science Foundation/
PT  - Journal Article
DEP - 20240110
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Child
MH  - Humans
MH  - *HLA Antigens/genetics
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-DRB1 Chains/genetics
MH  - *IgA Vasculitis/genetics
MH  - *Genetic Predisposition to Disease
PMC - PMC10815612
OTO - NOTNLM
OT  - Croatians
OT  - HLA-DRB1
OT  - IgA vasculitis
OT  - allele frequencies
OT  - high-resolution typing
OT  - human leukocyte antigen polymorphisms
OT  - next generation sequencing
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/23 06:43
MHDA- 2024/01/24 06:43
PMCR- 2024/01/10
CRDT- 2024/01/23 01:11
PHST- 2023/11/25 00:00 [received]
PHST- 2023/12/22 00:00 [revised]
PHST- 2024/01/09 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 06:43 [pubmed]
PHST- 2024/01/23 01:11 [entrez]
PHST- 2024/01/10 00:00 [pmc-release]
AID - ijms25020882 [pii]
AID - ijms-25-00882 [pii]
AID - 10.3390/ijms25020882 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Jan 10;25(2):882. doi: 10.3390/ijms25020882.