PMID- 38255955
OWN - NLM
STAT- MEDLINE
DCOM- 20240124
LR  - 20240201
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 2
DP  - 2024 Jan 10
TI  - Is Physical Activity an Efficient Strategy to Control the Adverse Effects of 
      Persistent Organic Pollutants in the Context of Obesity? A Narrative Review.
LID - 10.3390/ijms25020883 [doi]
LID - 883
AB  - Obesity affects nearly 660 million adults worldwide and is known for its many 
      comorbidities. Although the phenomenon of obesity is not fully understood, 
      science regularly reveals new determinants of this pathology. Among them, 
      persistent organic pollutants (POPs) have been recently highlighted. Mainly 
      lipophilic, POPs are normally stored in adipose tissue and can lead to adverse 
      metabolic effects when released into the bloodstream. The main objective of this 
      narrative review is to discuss the different pathways by which physical activity 
      may counteract POPs' adverse effects. The research that we carried out seems to 
      indicate that physical activity could positively influence several pathways 
      negatively influenced by POPs, such as insulin resistance, inflammation, lipid 
      accumulation, adipogenesis, and gut microbiota dysbiosis, that are associated 
      with the development of obesity. This review also indicates how, through the 
      controlled mobilization of POPs, physical activity could be a valuable approach 
      to reduce the concentration of POPs in the bloodstream. These findings suggest 
      that physical activity should be used to counteract the adverse effects of POPs. 
      However, future studies should accurately assess its impact in specific 
      situations such as bariatric surgery, where weight loss promotes POPs' blood 
      release.
FAU - Serrano, Quentin A
AU  - Serrano QA
AD  - Universite Cote d'Azur, LAMHESS, France.
FAU - Le Garf, Sebastien
AU  - Le Garf S
AD  - Universite Cote d'Azur, CHU, INSERM, C3M, France.
FAU - Martin, Vincent
AU  - Martin V
AUID- ORCID: 0000-0002-6681-1610
AD  - Universite Clermont Auvergne, AME2P, F-63000 Clermont-Ferrand, France.
AD  - Institut Universitaire de France (IUF), 75005 Paris, France.
FAU - Colson, Serge S
AU  - Colson SS
AUID- ORCID: 0000-0002-3315-9486
AD  - Universite Cote d'Azur, LAMHESS, France.
FAU - Chevalier, Nicolas
AU  - Chevalier N
AUID- ORCID: 0000-0001-7160-4301
AD  - Universite Cote d'Azur, CHU, INSERM, C3M, France.
LA  - eng
GR  - no number/Conseil Regional Provence-Alpes-Cote d'Azur/
GR  - ANR-15-IDEX-01/Agence Nationale de la Recherche/
PT  - Journal Article
PT  - Review
DEP - 20240110
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Persistent Organic Pollutants)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Persistent Organic Pollutants
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Obesity/etiology
MH  - *Environmental Pollutants/toxicity
MH  - Exercise
PMC - PMC10815489
OTO - NOTNLM
OT  - adipogenesis
OT  - adipose tissue
OT  - bariatric surgery
OT  - endocrine disruptors
OT  - inflammation
OT  - insulin resistance
OT  - lipid
OT  - microbiota
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/23 06:43
MHDA- 2024/01/24 06:43
PMCR- 2024/01/10
CRDT- 2024/01/23 01:11
PHST- 2023/11/13 00:00 [received]
PHST- 2023/12/21 00:00 [revised]
PHST- 2023/12/27 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 06:43 [pubmed]
PHST- 2024/01/23 01:11 [entrez]
PHST- 2024/01/10 00:00 [pmc-release]
AID - ijms25020883 [pii]
AID - ijms-25-00883 [pii]
AID - 10.3390/ijms25020883 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Jan 10;25(2):883. doi: 10.3390/ijms25020883.