PMID- 38255980
OWN - NLM
STAT- MEDLINE
DCOM- 20240124
LR  - 20240202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 2
DP  - 2024 Jan 11
TI  - Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic 
      Patients: A Postprandial Study.
LID - 10.3390/ijms25020908 [doi]
LID - 908
AB  - Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) 
      and may act as a daily stressor of the already dysfunctional diabetic platelets. 
      This study aims to investigate whether oleocanthal-rich olive oils (OO), 
      incorporated into a carbohydrate-rich meal, can affect postprandial dysmetabolism 
      and platelet aggregation. Oleocanthal is a cyclooxygenase inhibitor with putative 
      antiplatelet properties. In this randomized, single-blinded, crossover study, ten 
      T2DM patients consumed five isocaloric meals containing 120 g white bread 
      combined with: (i) 39 g butter, (ii) 39 g butter and 400 mg ibuprofen, (iii) 40 
      mL OO (phenolic content < 10 mg/Kg), (iv) 40 mL OO with 250 mg/Kg oleocanthal and 
      (v) 40 mL OO with 500 mg/Kg oleocanthal. Metabolic markers along with ex vivo 
      ADP- and thrombin receptor-activating peptide (TRAP)-induced platelet aggregation 
      were measured before and for 4 h after the meals. The glycemic and lipidemic 
      response was similar between meals. However, a sustained (90-240 min) 
      dose-dependent reduction in platelets' sensitivity to both ADP (50-100%) and TRAP 
      (20-50%) was observed after the oleocanthal meals in comparison to OO or butter 
      meals. The antiplatelet effect of the OO containing 500 mg/Kg oleocanthal was 
      comparable to that of the ibuprofen meal. In conclusion, the consumption of meals 
      containing oleocanthal-rich OO can reduce platelet activity during the 
      postprandial period, irrespective of postprandial hyperglycemia and lipidemia.
FAU - Katsa, Maria Efthymia
AU  - Katsa ME
AD  - Department of Nutrition and Dietetics, School of Health Sciences and Education, 
      Harokopio University of Athens, GR-17676 Athens, Greece.
FAU - Ketselidi, Kleopatra
AU  - Ketselidi K
AD  - Department of Nutrition and Dietetics, School of Health Sciences and Education, 
      Harokopio University of Athens, GR-17676 Athens, Greece.
FAU - Kalliostra, Marianna
AU  - Kalliostra M
AD  - Department of Nutrition and Dietetics, School of Health Sciences and Education, 
      Harokopio University of Athens, GR-17676 Athens, Greece.
FAU - Ioannidis, Anastasios
AU  - Ioannidis A
AUID- ORCID: 0000-0003-1880-7366
AD  - Laboratory of Biology and Biochemistry, Department of Nursing, Faculty of Health 
      Sciences, University of Peloponnese, GR-22100 Tripoli, Greece.
FAU - Rojas Gil, Andrea Paola
AU  - Rojas Gil AP
AUID- ORCID: 0000-0002-9812-2131
AD  - Laboratory of Biology and Biochemistry, Department of Nursing, Faculty of Health 
      Sciences, University of Peloponnese, GR-22100 Tripoli, Greece.
FAU - Diamantakos, Panagiotis
AU  - Diamantakos P
AD  - Laboratory of Pharmacognosy and Natural Products Chemistry, Department of 
      Pharmacy, National and Kapodistrian University of Athens, GR-15774 Athens, 
      Greece.
FAU - Melliou, Eleni
AU  - Melliou E
AD  - Laboratory of Pharmacognosy and Natural Products Chemistry, Department of 
      Pharmacy, National and Kapodistrian University of Athens, GR-15774 Athens, 
      Greece.
FAU - Magiatis, Prokopios
AU  - Magiatis P
AUID- ORCID: 0000-0002-0399-5344
AD  - Laboratory of Pharmacognosy and Natural Products Chemistry, Department of 
      Pharmacy, National and Kapodistrian University of Athens, GR-15774 Athens, 
      Greece.
FAU - Nomikos, Tzortzis
AU  - Nomikos T
AUID- ORCID: 0000-0003-0536-6397
AD  - Department of Nutrition and Dietetics, School of Health Sciences and Education, 
      Harokopio University of Athens, GR-17676 Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20240111
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - AC7QO6038O (oleocanthal)
RN  - 0 (Olive Oil)
RN  - WK2XYI10QM (Ibuprofen)
RN  - 8029-34-3 (Butter)
RN  - 0 (Cyclopentane Monoterpenes)
RN  - 0 (Aldehydes)
RN  - 0 (Phenols)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Olive Oil/pharmacology
MH  - Ibuprofen
MH  - Cross-Over Studies
MH  - Postprandial Period
MH  - Butter
MH  - *Cyclopentane Monoterpenes
MH  - *Aldehydes
MH  - *Phenols
PMC - PMC10815739
OTO - NOTNLM
OT  - dysmetabolism
OT  - oleocanthal
OT  - oleocanthal-rich olive oil
OT  - platelet aggregation
OT  - postprandial
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/23 06:42
MHDA- 2024/01/24 06:43
PMCR- 2024/01/11
CRDT- 2024/01/23 01:11
PHST- 2023/12/03 00:00 [received]
PHST- 2023/12/30 00:00 [revised]
PHST- 2024/01/03 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 06:42 [pubmed]
PHST- 2024/01/23 01:11 [entrez]
PHST- 2024/01/11 00:00 [pmc-release]
AID - ijms25020908 [pii]
AID - ijms-25-00908 [pii]
AID - 10.3390/ijms25020908 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Jan 11;25(2):908. doi: 10.3390/ijms25020908.