PMID- 38256272
OWN - NLM
STAT- MEDLINE
DCOM- 20240124
LR  - 20240228
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 2
DP  - 2024 Jan 18
TI  - Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPalpha in 
      Liver and Alters Various PPAR-alpha, PPAR-gamma, LXR-alpha Target Genes in Cholesterol-Rich 
      Diet Rabbit Model.
LID - 10.3390/ijms25021199 [doi]
LID - 1199
AB  - Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, 
      are natural products with proven beneficial impacts on the functions of the 
      cardiovascular system and the liver. This study aims to assess and compare 
      whether and to what extent two different doses of resin-purified cornelian cherry 
      extract (10 mg/kg b.w. or 50 mg/kg b.w.) applied in a cholesterol-rich diet 
      rabbit model affect the levels of sterol regulatory element-binding protein 1c 
      (SREBP-1c) and CCAAT/enhancer binding protein alpha (C/EBPalpha), and various liver X 
      receptor-alpha (LXR-alpha), peroxisome proliferator-activated receptor-alpha (PPAR-alpha), and 
      peroxisome proliferator-activated receptor-gamma (PPAR-gamma) target genes. Moreover, the 
      aim is to evaluate the resistive index (RI) of common carotid arteries (CCAs) and 
      aortas, and histopathological changes in CCAs. For this purpose, the levels of 
      SREBP-1c, C/EBPalpha, ATP-binding cassette transporter A1 (ABCA1), ATP-binding 
      cassette transporter G1 (ABCG1), fatty acid synthase (FAS), endothelial lipase 
      (LIPG), carnitine palmitoyltransferase 1A (CPT1A), and adiponectin receptor 2 
      (AdipoR2) in liver tissue were measured. Also, the levels of lipoprotein lipase 
      (LPL), visceral adipose tissue-derived serine protease inhibitor (Vaspin), and 
      retinol-binding protein 4 (RBP4) in visceral adipose tissue were measured. The RI 
      of CCAs and aortas, and histopathological changes in CCAs, were indicated. The 
      oral administration of the cornelian cherry extract decreased the SREBP-1c and 
      C/EBPalpha in both doses. The dose of 10 mg/kg b.w. increased ABCA1 and decreased 
      FAS, CPT1A, and RBP4, and the dose of 50 mg/kg b.w. enhanced ABCG1 and AdipoR2. 
      Mitigations in atheromatous changes in rabbits' CCAs were also observed. The 
      obtained outcomes were compared to the results of our previous works. The 
      beneficial results confirm that cornelian cherry fruit extract may constitute a 
      potentially effective product in the prevention and treatment of obesity-related 
      disorders.
FAU - Danielewski, Maciej
AU  - Danielewski M
AUID- ORCID: 0000-0002-2671-5747
AD  - Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 
      2, 50-345 Wroclaw, Poland.
FAU - Rapak, Andrzej
AU  - Rapak A
AUID- ORCID: 0000-0003-4897-0287
AD  - Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of 
      Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.
FAU - Kruszynska, Angelika
AU  - Kruszynska A
AD  - Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of 
      Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.
FAU - Malodobra-Mazur, Malgorzata
AU  - Malodobra-Mazur M
AD  - Department of Forensic Medicine, Division of Molecular Techniques, Wroclaw 
      Medical University, M. Sklodowskiej-Curie 52, 50-369 Wroclaw, Poland.
FAU - Oleszkiewicz, Pawel
AU  - Oleszkiewicz P
AD  - Department of Radiology and Imaging Diagnostics II, Lower Silesian Center of 
      Oncology, Pulmonology and Hematology, Grabiszynska 105, 53-439 Wroclaw, Poland.
FAU - Dzimira, Stanislaw
AU  - Dzimira S
AUID- ORCID: 0000-0001-7203-2392
AD  - Department of Pathology, Wroclaw University of Environmental and Life Sciences, 
      C. K. Norwida 31, 50-375 Wroclaw, Poland.
FAU - Kucharska, Alicja Z
AU  - Kucharska AZ
AUID- ORCID: 0000-0002-2172-0408
AD  - Department of Fruit, Vegetable, and Plant Nutraceutical Technology, Wroclaw 
      University of Environmental and Life Sciences, J. Chelmonskiego 37, 51-630 
      Wroclaw, Poland.
FAU - Slupski, Wojciech
AU  - Slupski W
AUID- ORCID: 0000-0002-0833-7711
AD  - Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 
      2, 50-345 Wroclaw, Poland.
FAU - Matuszewska, Agnieszka
AU  - Matuszewska A
AUID- ORCID: 0000-0003-1082-0793
AD  - Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 
      2, 50-345 Wroclaw, Poland.
FAU - Nowak, Beata
AU  - Nowak B
AUID- ORCID: 0000-0003-0014-6344
AD  - Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 
      2, 50-345 Wroclaw, Poland.
FAU - Szelag, Adam
AU  - Szelag A
AD  - Department of Pharmacology, Wroclaw Medical University, J. Mikulicza-Radeckiego 
      2, 50-345 Wroclaw, Poland.
FAU - Piorecki, Narcyz
AU  - Piorecki N
AD  - Bolestraszyce Arboretum and Institute of Physiography, Bolestraszyce 130, 37-722 
      Wyszatyce, Poland.
AD  - Institute of Physical Culture Sciences, Medical College, University of Rzeszow, 
      Cicha 2A, 35-326 Rzeszow, Poland.
FAU - Zaleska-Dorobisz, Urszula
AU  - Zaleska-Dorobisz U
AD  - Department of General and Pediatric Radiology, Wroclaw Medical University, M. 
      Sklodowskiej-Curie 50/52, 50-369 Wroclaw, Poland.
FAU - Sozanski, Tomasz
AU  - Sozanski T
AUID- ORCID: 0000-0003-1722-3190
AD  - Department of Preclinical Sciences, Pharmacology and Medical Diagnostics, Faculty 
      of Medicine, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 
      27, 50-370 Wroclaw, Poland.
LA  - eng
GR  - SUBK.A080.22.049/Wroclaw Medical University/
PT  - Journal Article
DEP - 20240118
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anthocyanins)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (CCAAT-Enhancer-Binding Protein-alpha)
RN  - 0 (Liver X Receptors)
RN  - 0 (Plant Extracts)
RN  - 0 (PPAR alpha)
RN  - 0 (PPAR gamma)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
SB  - IM
MH  - Animals
MH  - Rabbits
MH  - Anthocyanins
MH  - ATP-Binding Cassette Transporters
MH  - CCAAT-Enhancer-Binding Protein-alpha/genetics
MH  - *Cornus/chemistry
MH  - Diet
MH  - Fruit/chemistry
MH  - *Lagomorpha
MH  - Liver
MH  - Liver X Receptors/genetics
MH  - *Plant Extracts/pharmacology
MH  - PPAR alpha/genetics
MH  - PPAR gamma/genetics
MH  - Sterol Regulatory Element Binding Protein 1/genetics
PMC - PMC10816641
OTO - NOTNLM
OT  - ATP-binding cassette transporter
OT  - Cornus mas L.
OT  - adipokine
OT  - anthocyanin
OT  - atherosclerosis
OT  - cardiovascular disease
OT  - common carotid artery
OT  - cornelian cherry
OT  - iridoid
OT  - transcription factor
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/23 06:44
MHDA- 2024/01/24 06:43
PMCR- 2024/01/18
CRDT- 2024/01/23 01:13
PHST- 2023/12/23 00:00 [received]
PHST- 2024/01/13 00:00 [revised]
PHST- 2024/01/16 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 06:44 [pubmed]
PHST- 2024/01/23 01:13 [entrez]
PHST- 2024/01/18 00:00 [pmc-release]
AID - ijms25021199 [pii]
AID - ijms-25-01199 [pii]
AID - 10.3390/ijms25021199 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Jan 18;25(2):1199. doi: 10.3390/ijms25021199.