PMID- 38256370 OWN - NLM STAT- MEDLINE DCOM- 20240124 LR - 20240202 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 60 IP - 1 DP - 2024 Jan 6 TI - Differences in Health-Related Quality of Life among Patients with Heart Failure. LID - 10.3390/medicina60010109 [doi] LID - 109 AB - Heart failure (HF) is characterized by a progressive clinical course marked by frequent exacerbations and repeated hospitalizations, leading to considerably high morbidity and mortality rates. Patients with HF present with a constellation of bothersome symptoms, which range from physical to psychological and mental manifestations. With the transition to more advanced HF stages, symptoms become increasingly more debilitating, interfere with activities of daily living and disrupt multiple domains of life, including physical functioning, psychological status, emotional state, cognitive function, intimate relationships, lifestyle status, usual role activities, social contact and support. By inflicting profuse limitations in numerous aspects of life, HF exerts a profoundly negative impact on health-related quality of life (HRQOL). It is therefore not surprising that patients with HF display lower levels of HRQOL compared not only to the general healthy population but also to patients suffering from other chronic diseases. On top of this, poor HRQOL in patients with HF becomes an even greater concern considering that it has been associated with unfavorable long-term outcomes and poor prognosis. Nevertheless, HRQOL may differ significantly among patients with HF. Indeed, it has consistently been reported that women with HF display poorer HRQOL compared to men, while younger patients with HF tend to exhibit lower levels of HRQOL than their older counterparts. Moreover, patients presenting with higher New York Heart Association (NYHA) functional class (III-IV) have significantly more impaired HRQOL than those in a better NYHA class (I-II). Furthermore, most studies report worse levels of HRQOL in patients suffering from HF with preserved ejection fraction (HFpEF) compared to patients with HF with reduced ejection fraction (HFrEF) or HF with mildly reduced ejection fraction (HFmrEF). Last, but not least, differences in HRQOL have been noted depending on geographic location, with lower HRQOL levels having been recorded in Africa and Eastern Europe and higher in Western Europe in a recent large global study. Based on the observed disparities that have been invariably reported in the literature, this review article aims to provide insight into the underlying differences in HRQOL among patients with HF. Through an overview of currently existing evidence, fundamental differences in HRQOL among patients with HF are analyzed based on sex, age, NYHA functional class, ejection fraction and geographic location or ethnicity. FAU - Ventoulis, Ioannis AU - Ventoulis I AD - Department of Occupational Therapy, University of Western Macedonia, Keptse Area, 50200 Ptolemaida, Greece. FAU - Kamperidis, Vasileios AU - Kamperidis V AUID- ORCID: 0000-0001-8424-6718 AD - First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St Kiriakidi 1, 54636 Thessaloniki, Greece. FAU - Abraham, Maria Roselle AU - Abraham MR AD - Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, CA 94117, USA. FAU - Abraham, Theodore AU - Abraham T AD - Hypertrophic Cardiomyopathy Center of Excellence, University of California, San Francisco, CA 94117, USA. FAU - Boultadakis, Antonios AU - Boultadakis A AUID- ORCID: 0009-0002-4322-3266 AD - Emergency Medicine Department, Attikon University Hospital, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece. FAU - Tsioukras, Efthymios AU - Tsioukras E AD - Department of Occupational Therapy, University of Western Macedonia, Keptse Area, 50200 Ptolemaida, Greece. FAU - Katsiana, Aikaterini AU - Katsiana A AUID- ORCID: 0000-0002-7826-1353 AD - Department of Occupational Therapy, University of Western Macedonia, Keptse Area, 50200 Ptolemaida, Greece. FAU - Georgiou, Konstantinos AU - Georgiou K AD - Department of Occupational Therapy, University of Western Macedonia, Keptse Area, 50200 Ptolemaida, Greece. FAU - Parissis, John AU - Parissis J AD - Emergency Medicine Department, Attikon University Hospital, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece. FAU - Polyzogopoulou, Effie AU - Polyzogopoulou E AD - Emergency Medicine Department, Attikon University Hospital, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20240106 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Male MH - Humans MH - Female MH - *Quality of Life MH - *Heart Failure MH - Activities of Daily Living MH - Stroke Volume MH - Anxiety PMC - PMC10818915 OTO - NOTNLM OT - differences OT - health status OT - health-related quality of life OT - heart failure OT - patient-reported outcomes OT - quality of life COIS- The authors declare no conflicts of interest. EDAT- 2024/01/23 06:43 MHDA- 2024/01/24 06:42 PMCR- 2024/01/06 CRDT- 2024/01/23 01:14 PHST- 2023/11/16 00:00 [received] PHST- 2023/12/20 00:00 [revised] PHST- 2024/01/04 00:00 [accepted] PHST- 2024/01/24 06:42 [medline] PHST- 2024/01/23 06:43 [pubmed] PHST- 2024/01/23 01:14 [entrez] PHST- 2024/01/06 00:00 [pmc-release] AID - medicina60010109 [pii] AID - medicina-60-00109 [pii] AID - 10.3390/medicina60010109 [doi] PST - epublish SO - Medicina (Kaunas). 2024 Jan 6;60(1):109. doi: 10.3390/medicina60010109.