PMID- 38257161
OWN - NLM
STAT- MEDLINE
DCOM- 20240124
LR  - 20240202
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 16
IP  - 2
DP  - 2024 Jan 16
TI  - Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective 
      Management of Type 2 Diabetes.
LID - 10.3390/nu16020269 [doi]
LID - 269
AB  - Nutrition is one of the most influential environmental factors in both 
      taxonomical shifts in gut microbiota as well as in the development of type 2 
      diabetes mellitus (T2DM). Emerging evidence has shown that the effects of 
      nutrition on both these parameters is not mutually exclusive and that changes in 
      gut microbiota and related metabolites such as short-chain fatty acids (SCFAs) 
      and branched-chain amino acids (BCAAs) may influence systemic inflammation and 
      signaling pathways that contribute to pathophysiological processes associated 
      with T2DM. With this background, our review highlights the effects of 
      macronutrients, carbohydrates, proteins, and lipids, as well as micronutrients, 
      vitamins, and minerals, on T2DM, specifically through their alterations in gut 
      microbiota and the metabolites they produce. Additionally, we describe the 
      influences of common food groups, which incorporate varying combinations of these 
      macronutrients and micronutrients, on both microbiota and metabolic parameters in 
      the context of diabetes mellitus. Overall, nutrition is one of the first line 
      modifiable therapies in the management of T2DM and a better understanding of the 
      mechanisms by which gut microbiota influence its pathophysiology provides 
      opportunities for optimizing dietary interventions.
FAU - Hamamah, Sevag
AU  - Hamamah S
AUID- ORCID: 0000-0003-1372-3112
AD  - Department of Basic Medical Sciences, College of Osteopathic Medicine, Western 
      University of Health Sciences, Pomona, CA 91766, USA.
FAU - Iatcu, Oana C
AU  - Iatcu OC
AD  - Department of Biomedical Sciences, College of Medicine and Biological Science, 
      University of Suceava, 720229 Suceava, Romania.
FAU - Covasa, Mihai
AU  - Covasa M
AUID- ORCID: 0000-0002-6266-4457
AD  - Department of Basic Medical Sciences, College of Osteopathic Medicine, Western 
      University of Health Sciences, Pomona, CA 91766, USA.
AD  - Department of Biomedical Sciences, College of Medicine and Biological Science, 
      University of Suceava, 720229 Suceava, Romania.
LA  - eng
GR  - 120/16.09.2016./European Regional Development Fund through the Competitiveness 
      Operational Program/
PT  - Journal Article
PT  - Review
DEP - 20240116
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Vitamins)
RN  - 0 (Micronutrients)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - *Gastrointestinal Microbiome
MH  - Nutritional Status
MH  - Vitamins
MH  - Micronutrients
PMC - PMC10820857
OTO - NOTNLM
OT  - food groups
OT  - gut bacteria
OT  - insulin resistance
OT  - macronutrients
OT  - micronutrients
COIS- The authors declare no conflicts of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2024/01/23 06:42
MHDA- 2024/01/24 06:43
PMCR- 2024/01/16
CRDT- 2024/01/23 01:19
PHST- 2023/12/20 00:00 [received]
PHST- 2024/01/15 00:00 [revised]
PHST- 2024/01/15 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 06:42 [pubmed]
PHST- 2024/01/23 01:19 [entrez]
PHST- 2024/01/16 00:00 [pmc-release]
AID - nu16020269 [pii]
AID - nutrients-16-00269 [pii]
AID - 10.3390/nu16020269 [doi]
PST - epublish
SO  - Nutrients. 2024 Jan 16;16(2):269. doi: 10.3390/nu16020269.