PMID- 38258297
OWN - NLM
STAT- Publisher
LR  - 20240123
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
DP  - 2024 Jan 22
TI  - Mechanistic Target of Rapamycin Kinase is a Common Convergent Pathway to Renal 
      Neoplasia: A Contemporary Review.
PG  - 10668969231219653
LID - 10.1177/10668969231219653 [doi]
AB  - Mechanistic target of rapamycin kinase (mTOR) is a member of the 
      phosphatidylinositol-3-hydroxide kinase (PI3 K)-related protein kinase family 
      that functions as a central regulator of cell growth, metabolism, proliferation, 
      and survival. The role of the TSC-mTOR signaling pathway in kidney tumors has 
      been implicated in some hamartoma syndromes; however, with the advent and wide 
      utilization of molecular studies, a growing number of kidney tumors have been 
      linked to somatic or germline mutations involving genes that encode for this 
      pathway, including eosinophilic solid and cystic renal cell carcinoma, low-grade 
      oncocytic tumor, eosinophilic vacuolated tumor, renal cell carcinoma with 
      fibromyomatous stroma and angiomyolipoma, among others. Herein, we review the 
      contemporary developments of mTOR pathway-related renal neoplasia, focusing on 
      the clinicopathologic features of the tumor entities.
FAU - Alruwaii, Zainab I
AU  - Alruwaii ZI
AD  - Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, 
      Dammam, KSA.
FAU - Williamson, Sean R
AU  - Williamson SR
AUID- ORCID: 0000-0002-3898-1460
AD  - Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH, 
      USA.
FAU - Al-Obaidy, Khaleel I
AU  - Al-Obaidy KI
AUID- ORCID: 0000-0001-9890-8751
AD  - Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, 
      USA.
AD  - Department of Medicine, College of Human Medicine, Michigan State University, 
      East Lansing, MI, USA.
LA  - eng
PT  - Journal Article
DEP - 20240122
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
SB  - IM
OTO - NOTNLM
OT  - kidney, tuberous sclerosis, MTOR, renal cell, tumor, carcinoma
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/01/23 06:43
MHDA- 2024/01/23 06:43
CRDT- 2024/01/23 02:52
PHST- 2024/01/23 06:43 [medline]
PHST- 2024/01/23 06:43 [pubmed]
PHST- 2024/01/23 02:52 [entrez]
AID - 10.1177/10668969231219653 [doi]
PST - aheadofprint
SO  - Int J Surg Pathol. 2024 Jan 22:10668969231219653. doi: 10.1177/10668969231219653.