PMID- 38259441
OWN - NLM
STAT- MEDLINE
DCOM- 20240124
LR  - 20240403
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Zinc intake ameliorates intestinal morphology and oxidative stress of broiler 
      chickens under heat stress.
PG  - 1308907
LID - 10.3389/fimmu.2023.1308907 [doi]
LID - 1308907
AB  - Zinc (Zn), an essential trace element for poultry, plays a crucial role in 
      promoting growth, improving feed conversion efficiency, enhancing antioxidant 
      activity, and preventing disease. This study investigated the impact of different 
      levels and sources of dietary Zn supplementation on the growth performance, 
      intestinal morphology and antioxidant activity of broiler chickens under heat 
      stress conditions. In this experiment, 1024 Xueshan chickens were divided into 
      eight groups and subjected to heat stress conditions with different levels of Zn 
      supplementation (30 mg/kg, 60 mg/kg, and 90 mg/kg) using organic or inorganic 
      sources. Our findings indicated that dietary Zn supplementation significantly 
      increased the feed-to-weight ratio of broilers during the experimental period 
      under heat stress. Moreover, Zn supplementation positively increased the villus 
      height and villus width in the jejunum and ileum at 74 and 88 days old, with the 
      60 and 90 mg/kg groups outperforming other groups, and organic Zn was more 
      effective than inorganic Zn. Furthermore, Zn supplementation significantly 
      increased serum antioxidant levels, with higher superoxide dismutase (SOD), 
      malondialdehyde (MDA), and glutathione peroxidase (GSH-px) activities, and 
      organic Zn was more effective than inorganic Zn. This study concludes that Zn 
      supplementation is beneficial in mitigating the detrimental impacts of heat 
      stress on broilers. The findings suggest that employing Zn as a strategy can 
      enhance productivity in the poultry industry by positively influencing intestinal 
      morphology and bolstering antioxidant activity to counteract potential stress.
CI  - Copyright (c) 2024 Hu, Li, Peng, Yao, Zhu, Gu, Liu, Sun, Hu, Ennab, Luo and Cai.
FAU - Hu, Ping
AU  - Hu P
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Li, Kaiqi
AU  - Li K
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Peng, Xiaoxu
AU  - Peng X
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Yao, Tongjia
AU  - Yao T
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Zhu, Chuyang
AU  - Zhu C
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Gu, Haotian
AU  - Gu H
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Liu, Hao-Yu
AU  - Liu HY
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
AD  - International Joint Research Laboratory in Universities of Jiangsu Province of 
      China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou 
      University, Yangzhou, China.
FAU - Sun, Ming-An
AU  - Sun MA
AD  - Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou 
      University, Yangzhou, China.
FAU - Hu, Yun
AU  - Hu Y
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Ennab, Wael
AU  - Ennab W
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
AD  - Department of Veterinary Biomedical Sciences, Botswana University of Agriculture 
      and Agriculture and Natural Resources, Gaborone, Botswana.
FAU - Luo, Xugang
AU  - Luo X
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
FAU - Cai, Demin
AU  - Cai D
AD  - College of Animal Science and Technology, Yangzhou University, Yangzhou, China.
AD  - International Joint Research Laboratory in Universities of Jiangsu Province of 
      China for Domestic Animal Germplasm Resources and Genetic Improvement, Yangzhou 
      University, Yangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240108
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Antioxidants)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - *Chickens
MH  - Antioxidants/pharmacology
MH  - Oxidative Stress
MH  - Zinc/pharmacology
MH  - *Heat Stress Disorders/prevention & control/veterinary
MH  - Heat-Shock Response
PMC - PMC10800777
OTO - NOTNLM
OT  - broiler
OT  - heat stress
OT  - intestinal morphology
OT  - oxidative stress
OT  - zinc
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The author(s) declared that they were an editorial board 
      member of Frontiers, at the time of submission. This had no impact on the peer 
      review process and the final decision.
EDAT- 2024/01/23 12:44
MHDA- 2024/01/24 06:43
PMCR- 2023/01/01
CRDT- 2024/01/23 10:26
PHST- 2023/10/07 00:00 [received]
PHST- 2023/12/18 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 12:44 [pubmed]
PHST- 2024/01/23 10:26 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1308907 [doi]
PST - epublish
SO  - Front Immunol. 2024 Jan 8;14:1308907. doi: 10.3389/fimmu.2023.1308907. 
      eCollection 2023.