PMID- 38259796
OWN - NLM
STAT- MEDLINE
DCOM- 20240125
LR  - 20240425
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 11
DP  - 2023
TI  - Association between exposure to polycyclic aromatic hydrocarbons and 
      endometriosis: data from the NHANES 2001-2006.
PG  - 1267124
LID - 10.3389/fpubh.2023.1267124 [doi]
LID - 1267124
AB  - AIM: To evaluate the association between urinary polycyclic aromatic hydrocarbon 
      (PAH) metabolites and the risk of endometriosis. METHODS: This cross-sectional 
      study obtained data on women aged 20-54 years from the National Health and 
      Nutrition Examination Survey (NHANES) 2001-2006. The weighted multivariate 
      logistic regression model was established to assess the association between the 
      eight urinary PAH metabolites and the risk of endometriosis. In this multivariate 
      analysis, the eight urinary PAH metabolites were adjusted with urinary 
      creatinine, and were divided into three groups according to tertiles: Tertile 1, 
      Tertile 2 and Tertile 3. To evaluate the overall association of mixed PAH 
      metabolites with endometriosis, the Bayesian kernel machine regression (BKMR) 
      model was applied. RESULTS: Totally 1,291 women were included, of which 90 
      (6.97%) had endometriosis and 1,201 (93.03%) did not have endometriosis. After 
      adjusting for age, race, smoking, age at menarche, hysterectomy, ovary removed, 
      female hormone use, and menopause, compared with the Tertile 1 group, the Tertile 
      2 and Tertile 3 groups of all PAH metabolites demonstrated no significant risk of 
      endometriosis. A positive tendency was found between mixed PAH metabolites and 
      endometriosis when all the metabolites were at their 60th percentile levels or 
      above compared with their median levels. When all the other metabolites were 
      fixed at their median levels, 1-hydroxynaphthalene was positively correlated with 
      endometriosis. Potential interactions existed between 1-hydroxynaphthalene and 
      2-hydroxynaphthalene and between 2-hydroxyfluorene and 3-hydroxyfluorene. 
      CONCLUSION: No significant association was found between individual PAH 
      metabolites and endometriosis. A positive association existed between mixed PAH 
      metabolites and the risk of endometriosis.
CI  - Copyright (c) 2024 Zhang and Yang.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu, China.
FAU - Yang, Xiaojun
AU  - Yang X
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow 
      University, Suzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240108
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - 2A71EAQ389 (1-naphthol)
RN  - 0 (Naphthols)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Female
MH  - Humans
MH  - Bayes Theorem
MH  - Cross-Sectional Studies
MH  - *Endometriosis/epidemiology
MH  - *Naphthols
MH  - Nutrition Surveys
MH  - *Polycyclic Aromatic Hydrocarbons/adverse effects
MH  - Young Adult
MH  - Adult
MH  - Middle Aged
PMC - PMC10801278
OTO - NOTNLM
OT  - BKMR
OT  - NHANES
OT  - endometriosis
OT  - exposure
OT  - polycyclic aromatic hydrocarbon
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/23 12:42
MHDA- 2024/01/24 06:43
PMCR- 2024/01/08
CRDT- 2024/01/23 10:30
PHST- 2023/07/26 00:00 [received]
PHST- 2023/09/25 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/23 12:42 [pubmed]
PHST- 2024/01/23 10:30 [entrez]
PHST- 2024/01/08 00:00 [pmc-release]
AID - 10.3389/fpubh.2023.1267124 [doi]
PST - epublish
SO  - Front Public Health. 2024 Jan 8;11:1267124. doi: 10.3389/fpubh.2023.1267124. 
      eCollection 2023.