PMID- 38261566
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240222
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 56
IP  - 1
DP  - 2024 Dec
TI  - Prognostic value of plasma secretoneurin concentration in patients with heart 
      failure with reduced ejection fraction in one-year follow-up.
PG  - 2305309
LID - 10.1080/07853890.2024.2305309 [doi]
LID - 2305309
AB  - BACKGROUND: This is the first study to examine the clinical utility of measuring 
      plasma secretoneurin (SN) levels in patients with heart failure with reduced 
      ejection fraction (HFrEF), as a predictor of unplanned hospitalization, and 
      all-cause mortality independently, and as a composite endpoint at one-year 
      follow-up. METHODS: The study group includes 124 caucasian patients in New York 
      Heart Association (NYHA) classes II to IV. Plasma SN concentrations were 
      statistically analyzed in relation to sex, age, BMI, etiology of HFrEF, 
      pharmacotherapy, clinical, laboratory and echocardiographic parameters. Samples 
      were collected within 24 h of admission to the hospital. KEY RESULTS: In the 
      12-month follow-up, high SN levels were noted for all three endpoints. 
      CONCLUSIONS: SN positively correlates with HF severity measured by NYHA classes 
      and proves to be a useful prognostic parameter in predicting unplanned 
      hospitalizations and all-cause mortality among patients with HFrEF. Patients with 
      high SN levels may benefit from systematic follow-up and may be candidates for 
      more aggressive treatment.
FAU - Wolowiec, Lukasz
AU  - Wolowiec L
AUID- ORCID: 0000-0002-7731-6367
AD  - Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, 
      Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Torun, Poland.
FAU - Rogowicz, Daniel
AU  - Rogowicz D
AUID- ORCID: 0000-0001-8440-902X
AD  - Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, 
      Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Torun, Poland.
FAU - Budzynski, Jacek
AU  - Budzynski J
AUID- ORCID: 0000-0002-8867-8398
AD  - Department of Vascular and Internal Diseases, Collegium Medicum in Bydgoszcz, 
      Nicolaus Copernicus University, Torun, Poland.
FAU - Banach, Joanna
AU  - Banach J
AD  - Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, 
      Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Torun, Poland.
FAU - Wolowiec, Anna
AU  - Wolowiec A
AUID- ORCID: 0000-0001-7536-7809
AD  - Department of Geriatrics, Division of Biochemistry and Biogerontology, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
FAU - Kozakiewicz, Mariusz
AU  - Kozakiewicz M
AUID- ORCID: 0000-0002-6988-3038
AD  - Department of Geriatrics, Division of Biochemistry and Biogerontology, Collegium 
      Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
FAU - Bielinski, Maciej
AU  - Bielinski M
AUID- ORCID: 0000-0001-8345-7214
AD  - Department of Clinical Neuropsychology, Nicolaus Copernicus University in Torun, 
      Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.
FAU - Jasniak, Albert
AU  - Jasniak A
AUID- ORCID: 0000-0002-4270-1425
AD  - Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, 
      Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Torun, Poland.
FAU - Osiak, Joanna
AU  - Osiak J
AUID- ORCID: 0000-0002-6310-9981
AD  - Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, 
      Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Torun, Poland.
FAU - Grzesk, Grzegorz
AU  - Grzesk G
AUID- ORCID: 0000-0001-6669-5931
AD  - Department of Cardiology and Clinical Pharmacology, Faculty of Health Sciences, 
      Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 
      Torun, Poland.
LA  - eng
PT  - Journal Article
DEP - 20240123
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Neuropeptides)
RN  - 0 (Secretogranin II)
RN  - 149146-12-3 (secretoneurin)
RN  - 0 (SCG2 protein, human)
SB  - IM
MH  - Humans
MH  - Follow-Up Studies
MH  - *Heart Failure
MH  - *Neuropeptides
MH  - Prognosis
MH  - *Secretogranin II
MH  - Stroke Volume
PMC - PMC10810662
OTO - NOTNLM
OT  - HFrEF
OT  - Secretoneurin
OT  - biomarker
OT  - cardiovascular system
OT  - heart failure
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2024/01/23 18:42
MHDA- 2024/01/25 06:43
PMCR- 2024/01/23
CRDT- 2024/01/23 13:33
PHST- 2024/01/25 06:43 [medline]
PHST- 2024/01/23 18:42 [pubmed]
PHST- 2024/01/23 13:33 [entrez]
PHST- 2024/01/23 00:00 [pmc-release]
AID - 2305309 [pii]
AID - 10.1080/07853890.2024.2305309 [doi]
PST - ppublish
SO  - Ann Med. 2024 Dec;56(1):2305309. doi: 10.1080/07853890.2024.2305309. Epub 2024 
      Jan 23.