PMID- 38263574
OWN - NLM
STAT- Publisher
LR  - 20240124
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
DP  - 2024 Jan 23
TI  - Major histocompatibility complex (MHC) gene frequency in acquired dermal macular 
      hyperpigmentation: a case control study.
LID - 10.1111/ijd.17017 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) allele frequencies have a known 
      association with the pathogenesis of various autoimmune diseases. METHODS: We 
      recruited 31 Indian patients of acquired dermal macular hyperpigmentation (ADMH) 
      and 60 unrelated, age-and-gender-matched healthy controls. After history and 
      clinical examination, 5 ml of blood in EDTA vials was collected. These samples 
      were subjected to DNA extraction and the expression of HLA A, B, C, DR, DQ-A, and 
      DQ-B was studied. RESULTS: There was a predominance of females with a gender 
      ratio of 23 : 8 and the most common phototype was Fitzpatrick type IV (83.9%). 
      There was a significant association of HLA A*03:01 (OR: 5.8, CI: 1.7-17.0, P = 
      0.005), HLA B*07:02 (OR: 5.3, CI: 1.9-14.6, P = 0.003), HLA C*07:02 (OR: 4.3, CI: 
      1.8-9.6, P = 0.001), HLA DRB1*10:01 (OR: 7.6, CI: 1.7-38.00, P = 0.022), and HLA 
      DRB1*15:02 (OR: 31.0, CI: 4.4-341.8, P < 0.001) with patients compared to 
      controls, whereas HLA DQB*03:01 was less associated with patients compared to 
      controls (OR: 0.2, CI: 0.0-0.6, P = 0.009). CONCLUSION: Patients with ADMH are 
      more likely to have the HLA A*03:01, HLA B 07*02, HLA C*07:02, HLA DRB1*10:01, 
      HLA DRB1*15:02 and less likely to have the HLA DQB*03:01 allele. Larger cohort 
      studies may thus be conducted studying these specific alleles.
CI  - (c) 2024 the International Society of Dermatology.
FAU - Vinay, Keshavamurthy
AU  - Vinay K
AUID- ORCID: 0000-0001-6323-4988
AD  - Department of Dermatology, Venereology & Leprology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Kamat, Divya
AU  - Kamat D
AD  - Department of Dermatology, Venereology & Leprology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Narayan R, Vignesh
AU  - Narayan R V
AUID- ORCID: 0000-0002-1791-965X
AD  - Department of Dermatology, Venereology & Leprology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Minz, Ranjana W
AU  - Minz RW
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Singh, Jagdeep
AU  - Singh J
AD  - Department of Immunopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Bishnoi, Anuradha
AU  - Bishnoi A
AD  - Department of Dermatology, Venereology & Leprology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Chatterjee, Debajyoti
AU  - Chatterjee D
AD  - Department of Histopathology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Parsad, Davinder
AU  - Parsad D
AD  - Department of Dermatology, Venereology & Leprology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
FAU - Kumaran, Muthu S
AU  - Kumaran MS
AD  - Department of Dermatology, Venereology & Leprology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh, India.
LA  - eng
GR  - None/Postgraduate Institute of Medical Education and Research, Chandigarh/
PT  - Journal Article
DEP - 20240123
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
EDAT- 2024/01/24 06:43
MHDA- 2024/01/24 06:43
CRDT- 2024/01/24 00:07
PHST- 2023/12/12 00:00 [revised]
PHST- 2023/09/13 00:00 [received]
PHST- 2023/12/28 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/24 06:43 [pubmed]
PHST- 2024/01/24 00:07 [entrez]
AID - 10.1111/ijd.17017 [doi]
PST - aheadofprint
SO  - Int J Dermatol. 2024 Jan 23. doi: 10.1111/ijd.17017.