PMID- 38264372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240125
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 12
DP  - 2023 Dec
TI  - Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A 
      Case Study of Familial Susceptibility.
PG  - e51010
LID - 10.7759/cureus.51010 [doi]
LID - e51010
AB  - Kikuchi-Fujimoto disease (KFD) is a rare and self-limiting disorder that 
      predominantly affects young individuals of Asian descent. This case report 
      describes familial KFD in partially human leukocyte antigen (HLA)-matched 
      siblings. An adolescent male presented with cervical lymphadenopathy and elevated 
      lactate dehydrogenase (LDH) levels, diagnosed by biopsy as KFD; approximately one 
      year later, his sister presented with similar symptoms. Both siblings were found 
      to carry the HLA-DPB1*0202 allele, which is commonly associated with KFD. These 
      cases highlight a genetic component in KFD and encourage further genetic research 
      to delineate the pathogenesis of the disease.
CI  - Copyright (c) 2023, Isoda et al.
FAU - Isoda, Atsushi
AU  - Isoda A
AD  - Department of Hematology, Iryohojin Hoshiiin, Maebashi, JPN.
FAU - Tahara, Kenichi
AU  - Tahara K
AD  - Department of Hematology, Maebashi Red Cross Hospital, Maebashi, JPN.
FAU - Ide, Munenori
AU  - Ide M
AD  - Department of Pathology, Maebashi Red Cross Hospital, Maebashi, JPN.
LA  - eng
PT  - Case Reports
DEP - 20231223
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10803893
OTO - NOTNLM
OT  - familial susceptibility
OT  - histiocytic necrotizing lymphadenitis
OT  - human leukocyte antigen
OT  - kikuchi-fujimoto disease
OT  - sibling
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/01/24 06:42
MHDA- 2024/01/24 06:43
PMCR- 2023/12/23
CRDT- 2024/01/24 03:51
PHST- 2023/12/23 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/24 06:42 [pubmed]
PHST- 2024/01/24 03:51 [entrez]
PHST- 2023/12/23 00:00 [pmc-release]
AID - 10.7759/cureus.51010 [doi]
PST - epublish
SO  - Cureus. 2023 Dec 23;15(12):e51010. doi: 10.7759/cureus.51010. eCollection 2023 
      Dec.