PMID- 38264746
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240125
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 13
DP  - 2023
TI  - Primary pulmonary nuclear protein of the testis midline carcinoma: case report 
      and systematic review with pooled analysis.
PG  - 1308432
LID - 10.3389/fonc.2023.1308432 [doi]
LID - 1308432
AB  - Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare tumor, with 
      particularly low incidence in the lungs, and a correspondingly poor prognosis. To 
      determine the clinicopathological characteristics, outcomes, and prognostic 
      factors of primary pulmonary NMC, a case was reported and a systematic review was 
      performed. Twenty-nine records, including ours, involving 62 cases, were finally 
      included. The median age at diagnosis was 29.5 years. At presentation, the most 
      common symptoms at presentation were cough (47.50%) and chest/back pain (37.50%). 
      In terms of diagnosis, 32.14% of NMC cases were identified through 
      immunohistochemistry (IHC); However, a greater number of cases may be 
      misdiagnosed initially, and ultimately, the diagnosis of NMC was confirmed 
      through a combination of IHC and fluorescence in situ hybridization (FISH). 
      Despite the clinical application of various chemotherapy-based treatments, the 
      actual effectiveness remains unsatisfactory. Furthermore, Cox regression analysis 
      of multiple factors identified male gender and concurrent presence of pleural 
      effusion as indicators of shorter survival time in patients. These results 
      emphasize the importance of increased diagnostic awareness among clinical and 
      pathology practitioners concerning NMC. While there is currently no established 
      standard for treating NMC, a treatment approach combining multiple methods shows 
      promise for future research. Concurrently, clinical and foundational 
      investigations addressing variables such as gender and the presence of pleural 
      effusion may yield valuable insights into the diagnosis and treatment of NMC.
CI  - Copyright (c) 2024 Zhao, Cao, Zha, Wang, Pan, Zhang and Hu.
FAU - Zhao, Dong
AU  - Zhao D
AD  - Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Cao, Wei
AU  - Cao W
AD  - Office of Cancer Screening, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking 
      Union Medical College, Beijing, China.
FAU - Zha, Shiqian
AU  - Zha S
AD  - Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Wang, Yixuan
AU  - Wang Y
AD  - Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Pan, Zhou
AU  - Pan Z
AD  - Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Zhang, Jingyi
AU  - Zhang J
AD  - Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan, China.
FAU - Hu, Ke
AU  - Hu K
AD  - Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan, China.
LA  - eng
PT  - Systematic Review
DEP - 20240109
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC10803636
OTO - NOTNLM
OT  - NUT midline carcinoma (NMC)
OT  - nuclear protein of the testis
OT  - pleural effusion
OT  - pulmonary
OT  - survival
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/01/24 06:42
MHDA- 2024/01/24 06:43
PMCR- 2023/01/01
CRDT- 2024/01/24 03:57
PHST- 2023/10/06 00:00 [received]
PHST- 2023/12/21 00:00 [accepted]
PHST- 2024/01/24 06:43 [medline]
PHST- 2024/01/24 06:42 [pubmed]
PHST- 2024/01/24 03:57 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2023.1308432 [doi]
PST - epublish
SO  - Front Oncol. 2024 Jan 9;13:1308432. doi: 10.3389/fonc.2023.1308432. eCollection 
      2023.