PMID- 38265915 OWN - NLM STAT- Publisher LR - 20240124 IS - 1558-254X (Electronic) IS - 0278-0062 (Linking) VI - PP DP - 2024 Jan 24 TI - Few-Shot Medical Image Segmentation via Generating Multiple Representative Descriptors. LID - 10.1109/TMI.2024.3358295 [doi] AB - Automatic medical image segmentation has witnessed significant development with the success of large models on massive datasets. However, acquiring and annotating vast medical image datasets often proves to be impractical due to the time consumption, specialized expertise requirements, and compliance with patient privacy standards, etc. As a result, Few-shot Medical Image Segmentation (FSMIS) has become an increasingly compelling research direction. Conventional FSMIS methods usually learn prototypes from support images and apply nearest-neighbor searching to segment the query images. However, only a single prototype cannot well represent the distribution of each class, thus leading to restricted performance. To address this problem, we propose to Generate Multiple Representative Descriptors (GMRD), which can comprehensively represent the commonality within the corresponding class distribution. In addition, we design a Multiple Affinity Maps based Prediction (MAMP) module to fuse the multiple affinity maps generated by the aforementioned descriptors. Furthermore, to address intra-class variation and enhance the representativeness of descriptors, we introduce two novel losses. Notably, our model is structured as a dual-path design to achieve a balance between foreground and background differences in medical images. Extensive experiments on four publicly available medical image datasets demonstrate that our method outperforms the state-of-the-art methods, and the detailed analysis also verifies the effectiveness of our designed module. FAU - Cheng, Ziming AU - Cheng Z FAU - Wang, Shidong AU - Wang S FAU - Xin, Tong AU - Xin T FAU - Zhou, Tao AU - Zhou T FAU - Zhang, Haofeng AU - Zhang H FAU - Shao, Ling AU - Shao L LA - eng PT - Journal Article DEP - 20240124 PL - United States TA - IEEE Trans Med Imaging JT - IEEE transactions on medical imaging JID - 8310780 SB - IM EDAT- 2024/01/24 18:42 MHDA- 2024/01/24 18:42 CRDT- 2024/01/24 12:23 PHST- 2024/01/24 18:42 [medline] PHST- 2024/01/24 18:42 [pubmed] PHST- 2024/01/24 12:23 [entrez] AID - 10.1109/TMI.2024.3358295 [doi] PST - aheadofprint SO - IEEE Trans Med Imaging. 2024 Jan 24;PP. doi: 10.1109/TMI.2024.3358295.