PMID- 38266348
OWN - NLM
STAT- MEDLINE
DCOM- 20240301
LR  - 20240301
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 306
DP  - 2024 Apr
TI  - Platelet-derived drug delivery systems: Pioneering treatment for cancer, 
      cardiovascular diseases, infectious diseases, and beyond.
PG  - 122478
LID - S0142-9612(24)00012-7 [pii]
LID - 10.1016/j.biomaterials.2024.122478 [doi]
AB  - Platelets play a critical role as circulating cells in the human body and 
      contribute to essential physiological processes such as blood clotting, 
      hemostasis, vascular repair, and thrombus formation. Currently, platelets are 
      extensively employed in the development of innovative biomimetic drug delivery 
      systems, offering significant enhancements in circulation time, biocompatibility, 
      and targeted delivery efficiency compared to conventional drug delivery 
      approaches. Leveraging the unique physiological functions of platelets, these 
      platelet-derived drug delivery systems (DDSs) hold great promise for the 
      treatment of diverse diseases, including cancer, cardiovascular diseases, 
      infectious diseases, wound healing and other diseases. This review primarily 
      focuses on the design and characteristics of existing platelet-derived DDSs, 
      including their preparation and characterization methods. Furthermore, this 
      review comprehensively outlines the applications of these materials across 
      various diseases, offering a holistic understanding of their therapeutic 
      potential. This study aimed to provide a comprehensive overview of the potential 
      value of these materials in clinical treatment, serving as a valuable reference 
      for the advancement of novel platelet-derived DDSs and their broader utilization 
      in the field of disease treatment.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Zhu, Yalan
AU  - Zhu Y
AD  - Department of Pharmacy, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, 
      321000, China.
FAU - Xu, Lingling
AU  - Xu L
AD  - Academy of Medical Engineering and Translational Medicine, Medical College, 
      Tianjin University, Tianjin, 300072, China.
FAU - Kang, Yong
AU  - Kang Y
AD  - Academy of Medical Engineering and Translational Medicine, Medical College, 
      Tianjin University, Tianjin, 300072, China.
FAU - Cheng, Qinzhen
AU  - Cheng Q
AD  - Department of Pharmacy, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, 
      321000, China. Electronic address: cqz2543507560@163.com.
FAU - He, Yiling
AU  - He Y
AD  - Department of Pharmacy, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, 
      321000, China. Electronic address: hyl970308@163.com.
FAU - Ji, Xiaoyuan
AU  - Ji X
AD  - Academy of Medical Engineering and Translational Medicine, Medical College, 
      Tianjin University, Tianjin, 300072, China; Medical College, Linyi University, 
      Linyi, 276000, China. Electronic address: jixiaoyuan@tju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240120
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
SB  - IM
MH  - Humans
MH  - *Cardiovascular Diseases/drug therapy
MH  - Drug Delivery Systems
MH  - Blood Platelets/physiology
MH  - *Neoplasms/drug therapy
MH  - *Communicable Diseases/drug therapy
OTO - NOTNLM
OT  - Disease treatment
OT  - Platelet
OT  - Platelet-derived drug delivery systems
OT  - Targeted delivery
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/01/25 00:42
MHDA- 2024/03/01 06:44
CRDT- 2024/01/24 18:01
PHST- 2023/11/14 00:00 [received]
PHST- 2024/01/14 00:00 [revised]
PHST- 2024/01/20 00:00 [accepted]
PHST- 2024/03/01 06:44 [medline]
PHST- 2024/01/25 00:42 [pubmed]
PHST- 2024/01/24 18:01 [entrez]
AID - S0142-9612(24)00012-7 [pii]
AID - 10.1016/j.biomaterials.2024.122478 [doi]
PST - ppublish
SO  - Biomaterials. 2024 Apr;306:122478. doi: 10.1016/j.biomaterials.2024.122478. Epub 
      2024 Jan 20.