PMID- 38267543
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1474-1784 (Electronic)
IS  - 1474-1776 (Linking)
VI  - 23
IP  - 4
DP  - 2024 Apr
TI  - Membrane transporters in drug development and as determinants of precision 
      medicine.
PG  - 255-280
LID - 10.1038/s41573-023-00877-1 [doi]
AB  - The effect of membrane transporters on drug disposition, efficacy and safety is 
      now well recognized. Since the initial publication from the International 
      Transporter Consortium, significant progress has been made in understanding the 
      roles and functions of transporters, as well as in the development of tools and 
      models to assess and predict transporter-mediated activity, toxicity and 
      drug-drug interactions (DDIs). Notable advances include an increased 
      understanding of the effects of intrinsic and extrinsic factors on transporter 
      activity, the application of physiologically based pharmacokinetic modelling in 
      predicting transporter-mediated drug disposition, the identification of 
      endogenous biomarkers to assess transporter-mediated DDIs and the determination 
      of the cryogenic electron microscopy structures of SLC and ABC transporters. This 
      article provides an overview of these key developments, highlighting unanswered 
      questions, regulatory considerations and future directions.
CI  - (c) 2024. Springer Nature Limited.
FAU - Galetin, Aleksandra
AU  - Galetin A
AUID- ORCID: 0000-0002-3933-5217
AD  - Centre for Applied Pharmacokinetic Research, School of Health Sciences, The 
      University of Manchester, Manchester, UK. Aleksandra.Galetin@manchester.ac.uk.
FAU - Brouwer, Kim L R
AU  - Brouwer KLR
AUID- ORCID: 0000-0003-1945-4929
AD  - Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of 
      Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
FAU - Tweedie, Donald
AU  - Tweedie D
AD  - Independent Consultant, Guilford, CT, USA.
FAU - Yoshida, Kenta
AU  - Yoshida K
AUID- ORCID: 0000-0003-4967-3831
AD  - Clinical Pharmacology, Genentech Research and Early Development, South San 
      Francisco, CA, USA.
FAU - Sjostedt, Noora
AU  - Sjostedt N
AUID- ORCID: 0000-0001-6960-7757
AD  - Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of 
      Helsinki, Helsinki, Finland.
FAU - Aleksunes, Lauren
AU  - Aleksunes L
AUID- ORCID: 0000-0002-0032-1037
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, Piscataway, NJ, USA.
FAU - Chu, Xiaoyan
AU  - Chu X
AD  - Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & 
      Co., Inc., Rahway, NJ, USA.
FAU - Evers, Raymond
AU  - Evers R
AD  - Preclinical Sciences and Translational Safety, Johnson & Johnson, Janssen 
      Pharmaceuticals, Spring House, PA, USA.
FAU - Hafey, Michael J
AU  - Hafey MJ
AD  - Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & 
      Co., Inc., Rahway, NJ, USA.
FAU - Lai, Yurong
AU  - Lai Y
AUID- ORCID: 0000-0001-9505-333X
AD  - Drug Metabolism, Gilead Sciences Inc., Foster City, CA, USA.
FAU - Matsson, Par
AU  - Matsson P
AUID- ORCID: 0000-0002-9094-2581
AD  - Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, 
      Gothenburg, Sweden.
FAU - Riselli, Andrew
AU  - Riselli A
AUID- ORCID: 0000-0002-0714-5726
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      San Francisco, San Francisco, CA, USA.
FAU - Shen, Hong
AU  - Shen H
AD  - Department of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb Research 
      and Development, Princeton, NJ, USA.
FAU - Sparreboom, Alex
AU  - Sparreboom A
AD  - Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State 
      University, Columbus, OH, USA.
FAU - Varma, Manthena V S
AU  - Varma MVS
AD  - Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer 
      Inc, Groton, CT, USA.
FAU - Yang, Jia
AU  - Yang J
AUID- ORCID: 0000-0002-3992-4070
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      San Francisco, San Francisco, CA, USA.
FAU - Yang, Xinning
AU  - Yang X
AD  - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. 
      Food and Drug Administration, Silver Spring, MD, USA.
FAU - Yee, Sook Wah
AU  - Yee SW
AUID- ORCID: 0000-0001-8121-8746
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      San Francisco, San Francisco, CA, USA.
FAU - Zamek-Gliszczynski, Maciej J
AU  - Zamek-Gliszczynski MJ
AD  - Drug Metabolism and PK, GlaxoSmithKline, Collegeville, PA, USA.
FAU - Zhang, Lei
AU  - Zhang L
AUID- ORCID: 0000-0002-0639-3162
AD  - Office of Research and Standards, Office of Generic Drugs, Center for Drug 
      Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
FAU - Giacomini, Kathleen M
AU  - Giacomini KM
AUID- ORCID: 0000-0001-8041-5430
AD  - Department of Bioengineering and Therapeutic Sciences, University of California, 
      San Francisco, San Francisco, CA, USA. Kathy.Giacomini@ucsf.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240124
PL  - England
TA  - Nat Rev Drug Discov
JT  - Nature reviews. Drug discovery
JID - 101124171
RN  - 0 (Membrane Transport Proteins)
SB  - IM
MH  - Humans
MH  - *Membrane Transport Proteins
MH  - *Precision Medicine
MH  - Drug Interactions
MH  - Drug Development
EDAT- 2024/01/25 00:42
MHDA- 2024/04/08 06:43
CRDT- 2024/01/24 23:21
PHST- 2023/12/12 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/01/25 00:42 [pubmed]
PHST- 2024/01/24 23:21 [entrez]
AID - 10.1038/s41573-023-00877-1 [pii]
AID - 10.1038/s41573-023-00877-1 [doi]
PST - ppublish
SO  - Nat Rev Drug Discov. 2024 Apr;23(4):255-280. doi: 10.1038/s41573-023-00877-1. 
      Epub 2024 Jan 24.