PMID- 38267843 OWN - NLM STAT- MEDLINE DCOM- 20240126 LR - 20240206 IS - 1471-2318 (Electronic) IS - 1471-2318 (Linking) VI - 24 IP - 1 DP - 2024 Jan 24 TI - The prevalence and impact of sarcopenia in older cardiac patients undergoing inpatient cardiac rehabilitation - results from a prospective, observational cohort pre-study. PG - 94 LID - 10.1186/s12877-024-04694-y [doi] LID - 94 AB - BACKGROUND: The prevalence of sarcopenia and its impact in older patients undergoing inpatient cardiac rehabilitation (iCR) after cardiac procedure has been insufficiently studied. The main aim of this study was to evaluate the prevalence of sarcopenia and quantify the functional capacity of older sarcopenic and non-sarcopenic patients participating in iCR. METHODS: Prospective, observational cohort study within the framework of the ongoing multicenter prehabilitation study "PRECOVERY". A sample of 122 patients >/=75 years undergoing iCR after cardiac procedure were recruited in four German iCR facilities and followed up 3 months later by telephone. At iCR (baseline), the Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls (SARC-F) questionnaire was used to identify sarcopenic patients. In addition, Katz-Index, Clinical Frailty Scale (CFS), handgrip strength (HGS), Short Physical Performance Battery (SPPB) and 6-minute walk distance (6MWD) measured functional capacity and frailty at baseline. Outcomes were prevalence of sarcopenia and the correlation of sarcopenia to functional capacity and frailty at baseline as well as the SARC-F score at follow-up. The Wilcoxon test was applied for pre-post-test analysis. Correlation between sarcopenia and 6MWD, SPPB score and HGS was tested with the eta coefficient with one-way ANOVA. RESULTS: Complete assessments were collected from 101 patients (79.9 +/- 4.0 years; 63% male). At baseline, the mean SARC-F score was 2.7 +/- 2.1; 35% with sarcopenia. Other baseline results were Katz-Index 5.7 +/- 0.9, CFS 3.2 +/- 1.4, HGS 24.9 +/- 9.9 kg, SPPB score 7.5 +/- 3.3 and 6MWD 288.8 +/- 136.5 m. Compared to baseline, fewer patients were sarcopenic (23% versus 35%) at follow-up. In the subgroup of sarcopenic patients at baseline (n = 35), pre-post comparison resulted in a significant SARC-F improvement (p = 0.017). There was a significant correlation between sarcopenia measured by SARC-F and poor results in the assessments of functional capacity (p < 0.001; r > 0.546). CONCLUSIONS: The prevalence of sarcopenia in older patients at iCR after cardiac procedure is high (35%) and remains high at follow-up (23%). Sarcopenia screening is important since the diagnosis of sarcopenia in these patients correlates significantly with poor functional capacity. The results indicate that these patients may benefit from prehabilitation aimed at improving perioperative outcomes, increasing functional capacity and mitigating adverse effects. TRIAL REGISTRATION: German Clinical Trials Register (DRKS; http://www.drks.de ; DRKS00032256). Retrospectively registered on 13 July 2023. CI - (c) 2024. The Author(s). FAU - Steinmetz, Carolin AU - Steinmetz C AD - Department of Geriatrics, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany. carolin.steinmetz@med.uni-goettingen.de. FAU - Krause, Laura AU - Krause L AD - Department of Geriatrics, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany. FAU - Sulejmanovic, Samra AU - Sulejmanovic S AD - Institute for Sports Science University of Hildesheim, Universitatsplatz 1, 31141, Hildesheim, Germany. FAU - Kaumkotter, Sabrina AU - Kaumkotter S AD - Schuchtermann-Schiller'sche Clinic, Ulmenallee 11, 49214, Bad Rothenfelde, Germany. FAU - Mengden, Thomas AU - Mengden T AD - Department of Rehabilitation, Kerckhoff Heart Center, Ludwigstr. 41, 61231, Bad Nauheim, Germany. FAU - Grefe, Clemens AU - Grefe C AD - Clinic and Rehabilitation Center Lippoldsberg, Birkenallee 1, 34399, Wesertal, Germany. FAU - Knoglinger, Ernst AU - Knoglinger E AD - Kirchberg Clinic, Bad Lauterberg, Kirchberg 7-11, 37431, Bad Lauterberg, Germany. FAU - Reiss, Nils AU - Reiss N AD - Schuchtermann-Schiller'sche Clinic, Ulmenallee 11, 49214, Bad Rothenfelde, Germany. FAU - Brixius, Klara AU - Brixius K AD - Institute of Cardiology and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University, Am Mungersdorfer Sportpark 6, 50933, Cologne, Germany. FAU - Bjarnason-Wehrens, Birna AU - Bjarnason-Wehrens B AD - Institute of Cardiology and Sports Medicine, Department Preventive and Rehabilitative Sport and Exercise Medicine, German Sport University, Am Mungersdorfer Sportpark 6, 50933, Cologne, Germany. FAU - Schmidt, Thomas AU - Schmidt T AD - Schuchtermann-Schiller'sche Clinic, Ulmenallee 11, 49214, Bad Rothenfelde, Germany. AD - Institute of Cardiology and Sports Medicine, Department Preventive and Rehabilitative Sport and Exercise Medicine, German Sport University, Am Mungersdorfer Sportpark 6, 50933, Cologne, Germany. FAU - von Haehling, Stephan AU - von Haehling S AD - Department of Cardiology and Pneumology, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany. AD - German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Robert-Koch-Str. 42a, 37075, Goettingen, Germany. FAU - Sadlonova, Monika AU - Sadlonova M AD - Department of Geriatrics, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany. AD - Department of Psychosomatic Medicine and Psychotherapy, University of Goettingen Medical Center, Robert-Koch-Str. 40, 37075, Goettingen, Germany. AD - Department of Cardiovascular and Thoracic Surgery, University of Goettingen Medical Center, Robert-Koch-Str. 40, 37075, Goettingen, Germany. AD - German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Robert-Koch-Str. 42a, 37075, Goettingen, Germany. FAU - von Arnim, Christine A F AU - von Arnim CAF AD - Department of Geriatrics, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany. AD - German Center for Cardiovascular Research (DZHK), Partner Site Goettingen, Robert-Koch-Str. 42a, 37075, Goettingen, Germany. FAU - Heinemann, Stephanie AU - Heinemann S AD - Department of Geriatrics, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20240124 PL - England TA - BMC Geriatr JT - BMC geriatrics JID - 100968548 SB - IM MH - Humans MH - Male MH - Aged MH - Female MH - Inpatients MH - *Sarcopenia/diagnosis/epidemiology MH - Prevalence MH - *Cardiac Rehabilitation MH - *Frailty MH - Hand Strength MH - Prospective Studies PMC - PMC10809534 OTO - NOTNLM OT - Cardiac rehabilitation OT - Cardiac surgery OT - Sarcopenia OT - Valve intervention COIS- CAFvA received honoraria from serving on the scientific advisory board of Biogen, Roche, Novo Nordisk and Dr. Willmar Schwabe GmbH & Co. KG and has received funding for travel as well as speaker honoraria from Biogen, Roche diagnostics AG, Medical Tribune Verlagsgesellschaft mbH, Landesvereinigung fur Gesundheit und Akademie fur Sozialmedizin Niedersachsen e. V. and Dr. Willmar Schwabe GmbH & Co. KG. CAFvA has received research support from Roche diagnostics AG and research funding from the Innovationsfond (Fund of the Federal Joint Committee, Gemeinsamer Bundesausschuss, G-BA Grants No. VF1_2016-201; 01NVF21010; 01VSF21019). The other authors declare that they have no competing interests. EDAT- 2024/01/25 00:42 MHDA- 2024/01/26 06:44 PMCR- 2024/01/24 CRDT- 2024/01/24 23:43 PHST- 2023/10/20 00:00 [received] PHST- 2024/01/10 00:00 [accepted] PHST- 2024/01/26 06:44 [medline] PHST- 2024/01/25 00:42 [pubmed] PHST- 2024/01/24 23:43 [entrez] PHST- 2024/01/24 00:00 [pmc-release] AID - 10.1186/s12877-024-04694-y [pii] AID - 4694 [pii] AID - 10.1186/s12877-024-04694-y [doi] PST - epublish SO - BMC Geriatr. 2024 Jan 24;24(1):94. doi: 10.1186/s12877-024-04694-y.