PMID- 38270835
OWN - NLM
STAT- Publisher
LR  - 20240125
IS  - 1559-0283 (Electronic)
IS  - 1085-9195 (Linking)
DP  - 2024 Jan 25
TI  - Gastrodin Suppresses the Progression of Atherosclerosis and Vascular Inflammation 
      by Regulating TLR4/NF-kappaB Pathway.
LID - 10.1007/s12013-024-01218-8 [doi]
AB  - Elevated levels of plasma triglycerides (TG) and cholesterol have been shown to 
      contribute to the pathogenesis of several cardiovascular risk factors, such as 
      atherosclerosis, a primary cause of mortality. Gastrodin (Gas) is an effective 
      polyphenol extracted from Chinese natural herbal Gastrodiae elata Blume, which 
      has been documented to be effective against atherosclerosis. However, the related 
      mechanisms remain largely unclear. The current investigation elucidated the 
      involvement of Gas in the development of AS generated by a high-fat diet in mice 
      lacking the apolipoprotein E gene (ApoE(-/-)). The findings of our study indicate 
      that the administration of Gas had a beneficial effect on hyperlipidemia in mice 
      that were given a high-fat diet and lacked the ApoE gene. Specifically, Gas 
      supplementation resulted in a reduction in blood levels of oxidized low-density 
      lipoprotein (ox-LDL), interleukin-6 (IL-6), monocyte chemoattractant protein-1 
      (MCP-1), and tumor necrosis factor-alpha (TNF-alpha). Additionally, the 
      administration of Gas resulted in the suppression of lesions in the en face 
      aortas of ApoE KO mice, accompanied by a modest improvement in lipid profiles. 
      The intervention demonstrated the capacity to impede the development of 
      atherosclerotic lesions and promote characteristics associated with plaque 
      stability. The administration of Gas prevented inflammation in the aorta by 
      decreasing the expression of IL-6, TNF-alpha, and MCP-1. Additionally, Gas had a 
      mitigating effect on TLR4/NF-kappaB pathway components in the aorta of ApoE(-/-) 
      mice. Furthermore, it has been shown that Gas has the potential to mitigate the 
      harm caused to human umbilical vein endothelial cells (HUVECs) by ox-LDL, perhaps 
      via inhibiting inflammation through the TLR4/NF-kappaB pathway. This study shows that 
      Gas may potentially mitigate the development of atherosclerosis via its 
      pleiotropic effects, including improvements in lipid profiles and 
      anti-inflammatory properties.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Dai, Bing
AU  - Dai B
AD  - Department of vascular surgery, Tianjin University Tianjin Hospital, Tianjin, 
      300000, China.
FAU - Liu, Cunfa
AU  - Liu C
AD  - Department of vascular surgery, Tianjin University Tianjin Hospital, Tianjin, 
      300000, China.
FAU - Zhang, Song
AU  - Zhang S
AD  - Department of vascular surgery, Tianjin University Tianjin Hospital, Tianjin, 
      300000, China.
FAU - Huang, Mei
AU  - Huang M
AD  - Department of vascular surgery, Tianjin University Tianjin Hospital, Tianjin, 
      300000, China.
FAU - Yin, Shugang
AU  - Yin S
AD  - Department of vascular surgery, Tianjin University Tianjin Hospital, Tianjin, 
      300000, China. tjyy0072020@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240125
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
SB  - IM
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Gastrodin
OT  - Inflammasome
OT  - TLR4/NF-kappaB
EDAT- 2024/01/25 12:43
MHDA- 2024/01/25 12:43
CRDT- 2024/01/25 11:16
PHST- 2023/11/21 00:00 [received]
PHST- 2024/01/04 00:00 [accepted]
PHST- 2024/01/25 12:43 [medline]
PHST- 2024/01/25 12:43 [pubmed]
PHST- 2024/01/25 11:16 [entrez]
AID - 10.1007/s12013-024-01218-8 [pii]
AID - 10.1007/s12013-024-01218-8 [doi]
PST - aheadofprint
SO  - Cell Biochem Biophys. 2024 Jan 25. doi: 10.1007/s12013-024-01218-8.