PMID- 38272290 OWN - NLM STAT- MEDLINE DCOM- 20240502 LR - 20240505 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 249 DP - 2024 May 15 TI - Prenatal current-use pesticide exposure and children's neurodevelopment at one year of age in the Infants' Environmental Health (ISA) birth cohort, Costa Rica. PG - 118222 LID - S0013-9351(24)00126-9 [pii] LID - 10.1016/j.envres.2024.118222 [doi] AB - BACKGROUND: Pesticide exposure may affect young children's neurodevelopment, but only few cohort studies have addressed possible effects of non-organophosphate pesticides. OBJECTIVE: We evaluated associations between prenatal current-use pesticide exposure and neurodevelopmental outcomes among 1-year-old children from the Infants' Environmental Health (ISA) birth cohort. METHODS: To determine prenatal pesticide exposure, we measured biomarkers of pyrimethanil, chlorpyrifos, synthetic pyrethroids, and 2,4-D in urine samples among 355 women, 1-3 times during pregnancy. One-year post-partum, we evaluated children's neurodevelopment with the Bayley Scales of Infant and Toddler Development 3rd edition (BSID-III). We assessed associations between exposures and neurodevelopmental outcomes (composite and z-scores) using single-chemical linear regression models adjusted for possible confounders (maternal education, parity, sex, gestational age at birth, child age, HOME-score, location of assessment, biomarkers of mancozeb), and studied effect-modification by sex. We evaluated non-linear associations of multiple pesticide exposures with Bayesian kernel machine regression (BKMR). RESULTS: We found higher prenatal urinary 2,4-D concentrations were associated with lower language (beta(per ten-fold increase) = -2.0, 95 % confidence interval (CI) = -3.5, -0.5) and motor (beta(per ten-fold increase) = -2.2, 95 %CI = -4.2, -0.1) composite scores among all children. Also, higher chlorpyrifos exposure [measured as urinary 3,5,6-trichloro-2-pyridinol (TCPy)] was associated with lower cognitive composite scores (beta(per ten-fold increase) = -1.9, 95 %CI = -4.7, 0.8), and lower motor composite scores among boys (beta(per ten-fold increase) = -3.8, 95 % CI = -7.7, 0.1) but not girls (beta(per ten-fold increase) = 2.3, 95 %CI = -1.6, 6.3, pINT = 0.11). Finally, higher pyrimethanil was associated with lower language abilities among girls, but not boys. Pyrethroid metabolite concentrations did not explain variability in BSID-III composite scores. Associations were similar for BSID-III z-scores, and we found no evidence for non-linear associations or mixture effects. DISCUSSION: Prenatal exposure to common-use pesticides may affect children's neurodevelopment at 1-year of age, some effects may be sex-specific. CI - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Conejo-Bolanos, L Diego AU - Conejo-Bolanos LD AD - Infants' Environmental Health Study (ISA), Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica; Institute for Interdisciplinary Studies in Childhood and Adolescence (INEINA), Universidad Nacional, Heredia, Costa Rica. FAU - Mora, Ana M AU - Mora AM AD - Infants' Environmental Health Study (ISA), Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica; Center for Environmental Research and Community Health (CERCH), University of California at Berkeley, United States. FAU - Hernandez-Bonilla, David AU - Hernandez-Bonilla D AD - National Institute of Public Health, Cuernavaca, Morelos, Mexico. FAU - Cano, Juan Camilo AU - Cano JC AD - Infants' Environmental Health Study (ISA), Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica. FAU - Menezes-Filho, Jose A AU - Menezes-Filho JA AD - Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Av. Barao de Jeremoabo s/n Campus, Universitario de Ondina, 40170-115, Salvador, Bahia, Brazil. FAU - Eskenazi, Brenda AU - Eskenazi B AD - Center for Environmental Research and Community Health (CERCH), University of California at Berkeley, United States. FAU - Lindh, Christian H AU - Lindh CH AD - Division of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University, SE-221 85, Lund, Sweden. FAU - van Wendel de Joode, Berna AU - van Wendel de Joode B AD - Infants' Environmental Health Study (ISA), Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica. Electronic address: berendina.vanwendel.dejoode@una.cr. LA - eng GR - D43 ES018745/ES/NIEHS NIH HHS/United States GR - R01 ES015572/ES/NIEHS NIH HHS/United States GR - R24 ES028526/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20240124 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Pesticides) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Infant MH - *Pesticides/urine/toxicity MH - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology MH - Male MH - *Child Development/drug effects MH - Costa Rica MH - Maternal Exposure/adverse effects MH - Birth Cohort MH - Environmental Pollutants/urine MH - Adult MH - Cohort Studies MH - Young Adult PMC - PMC11065598 MID - NIHMS1966649 OTO - NOTNLM OT - 2,4-D OT - Chlorpyrifos OT - Epidemiology OT - In-utero OT - Pesticides OT - Pyrimethanil COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/01/26 00:43 MHDA- 2024/05/03 00:50 PMCR- 2025/05/15 CRDT- 2024/01/25 19:17 PHST- 2023/08/22 00:00 [received] PHST- 2024/01/09 00:00 [revised] PHST- 2024/01/14 00:00 [accepted] PHST- 2025/05/15 00:00 [pmc-release] PHST- 2024/05/03 00:50 [medline] PHST- 2024/01/26 00:43 [pubmed] PHST- 2024/01/25 19:17 [entrez] AID - S0013-9351(24)00126-9 [pii] AID - 10.1016/j.envres.2024.118222 [doi] PST - ppublish SO - Environ Res. 2024 May 15;249:118222. doi: 10.1016/j.envres.2024.118222. Epub 2024 Jan 24.