PMID- 38274723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 1920-454X (Electronic)
IS  - 1920-4531 (Print)
IS  - 1920-4531 (Linking)
VI  - 15
IP  - 1
DP  - 2024 Feb
TI  - Clinical Outcomes of Curative Intent Radiotherapy by Helical Tomotherapy for 
      Laryngeal Squamous Cell Carcinoma: A Retrospective Analysis in a Tertiary 
      Referral Center.
PG  - 136-142
LID - 10.14740/wjon1638 [doi]
AB  - BACKGROUND: The management of laryngeal cancer involves balancing curative 
      treatment with preserving essential functions. This study aimed to evaluate the 
      clinical outcomes of helical tomotherapy, an advanced form of radiation therapy, 
      as a primary treatment modality for laryngeal squamous cell carcinoma (LSCC). 
      METHODS: A retrospective analysis of data obtained from a tertiary referral 
      center was performed to assess treatment response rates, survival outcomes, 
      disease control, and treatment-related adverse events. RESULTS: The study 
      included 45 patients with LSCC treated with helical tomotherapy between May 2015 
      and September 2022. The 5-year overall survival (OS) rate and disease-free 
      survival (DFS) rate were 89.2% and 71.1%, respectively. Local control and 
      laryngeal preservation rates at 5 years were 79.7% and 84.7%, respectively. 
      Subgroup analysis revealed higher DFS rates in early-stage patients (84.2%) 
      compared to advanced-stage patients (58.9%). CONCLUSIONS: The results indicate 
      that helical tomotherapy offers effective tumor control and potential for 
      laryngeal preservation in LSCC. Further prospective studies and longer follow-up 
      are needed to validate these findings and optimize treatment strategies for LSCC 
      patients.
CI  - Copyright 2024, Katano et al.
FAU - Katano, Atsuto
AU  - Katano A
AUID- ORCID: 0000-0003-4393-1828
AD  - Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan.
FAU - Yamashita, Hideomi
AU  - Yamashita H
AD  - Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231209
PL  - Canada
TA  - World J Oncol
JT  - World journal of oncology
JID - 101564097
PMC - PMC10807912
OTO - NOTNLM
OT  - Helical tomotherapy
OT  - Laryngeal squamous cell carcinoma
OT  - Radiation therapy
OT  - Survival rate
COIS- None to declare.
EDAT- 2024/01/26 06:44
MHDA- 2024/01/26 06:45
PMCR- 2023/12/09
CRDT- 2024/01/26 03:58
PHST- 2023/10/19 00:00 [received]
PHST- 2023/11/21 00:00 [accepted]
PHST- 2024/01/26 06:45 [medline]
PHST- 2024/01/26 06:44 [pubmed]
PHST- 2024/01/26 03:58 [entrez]
PHST- 2023/12/09 00:00 [pmc-release]
AID - 10.14740/wjon1638 [doi]
PST - ppublish
SO  - World J Oncol. 2024 Feb;15(1):136-142. doi: 10.14740/wjon1638. Epub 2023 Dec 9.