PMID- 38274979
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 0973-6247 (Print)
IS  - 1998-3565 (Electronic)
IS  - 0973-6247 (Linking)
VI  - 17
IP  - 2
DP  - 2023 Jul-Dec
TI  - Human leukocyte antigen alloimmunization prevention mechanisms in blood 
      transfusion.
PG  - 264-272
LID - 10.4103/ajts.ajts_144_21 [doi]
AB  - In many fields of clinical medicine and blood transfusion, the human leukocyte 
      antigen (HLA) system is crucial. Alloimmunization happens as a result of an 
      immune response to foreign antigens encountered during blood transfusion. This 
      gives rise to alloantibodies against red blood cells (RBCs), HLA, or human 
      platelet antigen (HPA). HLA alloimmunization following allogeneic transfusion was 
      shown to be a result of contaminating white blood cells (WBCs) present in the 
      product. It is a common complication of transfusion therapy that leads to 
      difficulties in clinical intolerance and refractoriness to platelet transfusion 
      during patient management. Single-donor platelets, prophylactic HLA matching, 
      leukoreduction, and irradiation of cellular blood products are some of the 
      mechanisms to prevent HLA alloimmunization during a blood transfusion. Now, the 
      best approach to reduce the occurrence of primary HLA alloimmunization is the 
      removal of WBCs from the blood by filtration.
CI  - Copyright: (c) 2022 Asian Journal of Transfusion Science.
FAU - Adane, Tiruneh
AU  - Adane T
AD  - Department of Hematology and Immunohematology, School of Biomedical and 
      Laboratory Sciences, College of Medicine and Health Sciences, University of 
      Gondar, Gondar, Ethiopia.
FAU - Enawgaw, Bamlaku
AU  - Enawgaw B
AD  - Department of Hematology and Immunohematology, School of Biomedical and 
      Laboratory Sciences, College of Medicine and Health Sciences, University of 
      Gondar, Gondar, Ethiopia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220928
PL  - India
TA  - Asian J Transfus Sci
JT  - Asian journal of transfusion science
JID - 101306858
PMC - PMC10807525
OTO - NOTNLM
OT  - Blood transfusion
OT  - human leukocyte antigen alloimmunization
OT  - human leukocyte antigen matching
OT  - leukoreduction
OT  - pathogen reduction
OT  - single-donor platelets
OT  - ultraviolet irradiation
COIS- There are no conflicts of interest.
EDAT- 2024/01/26 06:43
MHDA- 2024/01/26 06:44
PMCR- 2023/07/01
CRDT- 2024/01/26 04:01
PHST- 2021/09/23 00:00 [received]
PHST- 2021/11/01 00:00 [revised]
PHST- 2021/12/05 00:00 [accepted]
PHST- 2024/01/26 06:44 [medline]
PHST- 2024/01/26 06:43 [pubmed]
PHST- 2024/01/26 04:01 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - AJTS-17-264 [pii]
AID - 10.4103/ajts.ajts_144_21 [doi]
PST - ppublish
SO  - Asian J Transfus Sci. 2023 Jul-Dec;17(2):264-272. doi: 10.4103/ajts.ajts_144_21. 
      Epub 2022 Sep 28.