PMID- 38275217
OWN - NLM
STAT- MEDLINE
DCOM- 20240315
LR  - 20240315
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 134
IP  - 4
DP  - 2024 Apr
TI  - The role of ATP-binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A 
      review of the mechanisms.
PG  - 423-438
LID - 10.1111/bcpt.13981 [doi]
AB  - The maintenance of cholesterol homeostasis is essential for central nervous 
      system function. Consequently, factors that affect cholesterol homeostasis are 
      linked to neurological disorders and pathologies. Among them, ATP-binding 
      cassette transporter G1 (ABCG1) plays a significant role in atherosclerosis. 
      However, its role in Alzheimer's disease (AD) is unclear. There is inconsistent 
      information regarding ABCG1's role in AD. It can increase or decrease amyloid beta 
      (Abeta) levels in animals' brains. Clinical studies show that ABCG1 is involved in 
      AD patients' impairment of cholesterol efflux capacity (CEC) in the cerebrospinal 
      fluid (CSF). Lower Abeta levels in the CSF are correlated with ABCG1-mediated CEC 
      dysfunction. ABCG1 modulates alpha-, beta-, and gamma-secretase activities in the plasma 
      membrane and may affect Abeta production in the mitochondria-associated endoplasmic 
      reticulum (ER) membrane (MAM) cell compartment. Despite contradictory findings 
      regarding ABCG1's role in AD, this review shows that ABCG1 has a role in Abeta 
      generation via modulation of membrane secretases. It is, however, necessary to 
      investigate the underlying mechanism(s). ABCG1 may also contribute to AD 
      pathology through its role in apoptosis and oxidative stress. As a result, ABCG1 
      plays a role in AD and is a candidate for drug development.
CI  - (c) 2024 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society). Published by John Wiley & Sons Ltd.
FAU - Yazdi, Mohsen Karbasi
AU  - Yazdi MK
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Alavi, Mohaddeseh Sadat
AU  - Alavi MS
AD  - Pharmacological Research Center of Medicinal Plants, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
AD  - Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Roohbakhsh, Ali
AU  - Roohbakhsh A
AUID- ORCID: 0000-0001-5032-4263
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
LA  - eng
GR  - Mashhad University of Medical Sciences/
PT  - Journal Article
PT  - Review
DEP - 20240126
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Alzheimer Disease/pathology
MH  - Amyloid beta-Peptides/metabolism
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Brain/metabolism
MH  - Cholesterol/metabolism
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1/genetics/metabolism
OTO - NOTNLM
OT  - ABC transporters
OT  - ABCG1
OT  - Alzheimer's disease
OT  - Cholesterol
OT  - beta secretase
EDAT- 2024/01/26 12:43
MHDA- 2024/03/15 06:44
CRDT- 2024/01/26 07:48
PHST- 2024/01/04 00:00 [revised]
PHST- 2023/08/08 00:00 [received]
PHST- 2024/01/08 00:00 [accepted]
PHST- 2024/03/15 06:44 [medline]
PHST- 2024/01/26 12:43 [pubmed]
PHST- 2024/01/26 07:48 [entrez]
AID - 10.1111/bcpt.13981 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2024 Apr;134(4):423-438. doi: 10.1111/bcpt.13981. 
      Epub 2024 Jan 26.