PMID- 38275656
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240128
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 13
IP  - 1
DP  - 2024 Jan 22
TI  - Peiminine Exerts Its Anti-Acne Effects by Regulating the NF-kappaB Pathway.
LID - 10.3390/antiox13010131 [doi]
LID - 131
AB  - Peiminine is the main natural alkaloid compound extracted from the Chinese herb 
      Fritillaria. Although peiminine is known for its antioxidant and 
      anti-inflammatory effects in conditions such as mastitis and arthritis, its 
      impact on inflammation induced by Cutibacterisum acnes (C. acnes) has not been 
      explored. The aim of this study was to investigate the effect of peiminine on C. 
      acnes-induced inflammatory responses in the skin and to identify the underlying 
      mechanism involved. We discovered that peiminine inhibits the C. acnes-induced 
      expression of inflammatory mediators such as pro-interleukin-1beta (pro-IL-1beta), 
      cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 
      (IL-6) in mouse bone marrow-derived macrophages (BMDMs). Peiminine suppressed the 
      activation of nuclear factor-kappa B (NF-kappaB) without affecting the activation of 
      mitogen-activated protein kinase (MAPK) pathways such as JNK, ERK, and p38 MAPK. 
      In addition, we found that peiminine suppressed inflammatory cytokine expression 
      and ameliorated histological symptoms in C. acnes-induced mouse skin. Our study 
      is the first to provide evidence that peiminine has an inhibitory effect on acne, 
      and it points toward the potential of incorporating peiminine into cosmetic and 
      pharmaceutical formulations for acne treatment.
FAU - Cha, So Jin
AU  - Cha SJ
AD  - Department of Molecular Bioscience, College of Biomedical Science, Kangwon 
      National University, Chuncheon 24341, Republic of Korea.
FAU - Kim, Seon Sook
AU  - Kim SS
AUID- ORCID: 0000-0003-2874-6974
AD  - Institute of Life Science, Kangwon National University, Chuncheon 24341, Republic 
      of Korea.
FAU - Shin, Jin Hak
AU  - Shin JH
AD  - Department of Molecular Bioscience, College of Biomedical Science, Kangwon 
      National University, Chuncheon 24341, Republic of Korea.
FAU - Seo, Su Ryeon
AU  - Seo SR
AUID- ORCID: 0000-0002-4830-4965
AD  - Department of Molecular Bioscience, College of Biomedical Science, Kangwon 
      National University, Chuncheon 24341, Republic of Korea.
AD  - Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 
      24341, Republic of Korea.
LA  - eng
GR  - 2021R1A2C1008170/National Research Foundation of Korea/
GR  - IITP-2023-00260267/Ministry of Science and ICT/
GR  - National University Development Project 2023/Kangwon National University/
PT  - Journal Article
DEP - 20240122
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10812726
OTO - NOTNLM
OT  - Cutibacterisum acnes
OT  - acne vulgaris
OT  - inflammation
OT  - peiminine
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/26 12:43
MHDA- 2024/01/26 12:44
PMCR- 2024/01/22
CRDT- 2024/01/26 09:15
PHST- 2023/12/11 00:00 [received]
PHST- 2024/01/16 00:00 [revised]
PHST- 2024/01/19 00:00 [accepted]
PHST- 2024/01/26 12:44 [medline]
PHST- 2024/01/26 12:43 [pubmed]
PHST- 2024/01/26 09:15 [entrez]
PHST- 2024/01/22 00:00 [pmc-release]
AID - antiox13010131 [pii]
AID - antioxidants-13-00131 [pii]
AID - 10.3390/antiox13010131 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2024 Jan 22;13(1):131. doi: 10.3390/antiox13010131.