PMID- 38277409
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 2472-1727 (Electronic)
VI  - 116
IP  - 1
DP  - 2024 Jan
TI  - Effects of music on cognitive behavioral impairments in both sex of adult rats 
      exposed prenatally to valproic acid.
PG  - e2300
LID - 10.1002/bdr2.2300 [doi]
AB  - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder 
      characterized by impairment in reciprocal social interactions, deficits in 
      communication, and restrictive and repetitive behaviors and interests. In 
      previous studies, music has been identified as an intervention therapy for 
      children with ASD. OBJECTIVES: The present study evaluated the effects of music 
      on cognitive behavioral impairments in both sexes of adult rats exposed 
      prenatally to Valproic acid. METHODS: For induction of autism, pregnant female 
      rats were pretreated with either saline or VPA (600 mg/kg.i.p.) at gestational 
      day (GD) 12.5. Male and female offspring were divided into Saline.Non-Music, 
      VPA.Non-Music, Saline.Music, and VPA.Music groups. The adult rats in the music 
      groups were exposed to Mozart's piano sonata K.448 for 30 days (4 h/day), from 
      postnatal day (PND) 60 to 90. Social interaction and Morris water maze (MWM) 
      tasks were tested at PND 90. RESULTS: Our results revealed that prenatal exposure 
      to VPA decreased sociability and social memory performance in both sexes of adult 
      rats. Moreover, prenatal exposure to VPA created learning and memory impairments 
      in both sexes of adult rats in the MWM task. Music intervention improved 
      sociability in both sexes of VPA-exposed rats and social memory in both sexes of 
      VPA-exposed rats, especially in females. Furthermore, our results revealed that 
      music ameliorated learning impairments in VPA-exposed female rats in the MWM 
      task. In addition, music improved spatial memory impairments in VPA-exposed rats 
      of both sexes, especially in females, which needs more investigation in molecular 
      and histological fields in future studies. CONCLUSION: Music intervention 
      improved sociability and social memory in adult VPA-exposed rats, especially in 
      female animals. Furthermore, music improved memory impairments in VPA-exposed 
      rats of both sexes. It seems that music had a better influence on female rats. 
      However, future studies need more investigations in molecular and histological 
      fields.
CI  - (c) 2024 Wiley Periodicals LLC.
FAU - Taheri, Farahnaz
AU  - Taheri F
AUID- ORCID: 0000-0002-5361-4466
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
FAU - Joushi, Sara
AU  - Joushi S
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
FAU - Mohammadipoor-Ghasemabad, Lily
AU  - Mohammadipoor-Ghasemabad L
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
FAU - Rad, Iman
AU  - Rad I
AD  - Pathology and Stem Cell Research Center Afzalipour Medical University of Medical 
      Science, Kerman, Iran.
FAU - Esmaeilpour, Khadijeh
AU  - Esmaeilpour K
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
AD  - School of Public Health Sciences, University of Waterloo, Waterloo, Canada.
FAU - Sheibani, Vahid
AU  - Sheibani V
AD  - Neuroscience Research Center, Institute of Neuropharmacology, Kerman University 
      of Medical Sciences, Kerman, Iran.
LA  - eng
GR  - Kerman Neuroscience Research Center, Kerman University of Medical Sciences, 
      Kerman, Iran/
PT  - Journal Article
PL  - United States
TA  - Birth Defects Res
JT  - Birth defects research
JID - 101701004
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Humans
MH  - Pregnancy
MH  - Child
MH  - Rats
MH  - Male
MH  - Female
MH  - Animals
MH  - Valproic Acid/pharmacology
MH  - *Autism Spectrum Disorder
MH  - *Prenatal Exposure Delayed Effects/pathology
MH  - *Music
MH  - Cognition
OTO - NOTNLM
OT  - autism
OT  - learning and memory
OT  - music intervention
OT  - rat
OT  - social interaction
EDAT- 2024/01/26 18:42
MHDA- 2024/01/29 06:43
CRDT- 2024/01/26 13:44
PHST- 2023/12/23 00:00 [revised]
PHST- 2023/09/03 00:00 [received]
PHST- 2023/12/31 00:00 [accepted]
PHST- 2024/01/29 06:43 [medline]
PHST- 2024/01/26 18:42 [pubmed]
PHST- 2024/01/26 13:44 [entrez]
AID - 10.1002/bdr2.2300 [doi]
PST - ppublish
SO  - Birth Defects Res. 2024 Jan;116(1):e2300. doi: 10.1002/bdr2.2300.