PMID- 38278193
OWN - NLM
STAT- Publisher
LR  - 20240225
IS  - 1542-7714 (Electronic)
IS  - 1542-3565 (Linking)
DP  - 2024 Jan 24
TI  - High Diagnostic Yield of Abnormal Endoscopic Findings in the Evaluation of 
      Laryngopharyngeal Reflux.
LID - S1542-3565(24)00087-9 [pii]
LID - 10.1016/j.cgh.2024.01.012 [doi]
AB  - Esophagogastroduodenoscopy (EGD) is recommended in patients with typical 
      gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation, chest 
      pain) in the setting of proton pump inhibitor (PPI) nonresponse. EGD evaluates 
      for erosive disease, assesses antireflux barrier integrity, excludes non-GERD 
      conditions, and, in the absence of erosive findings, is followed by reflux 
      testing.(1,2) The diagnostic utility of EGD is less clear in the evaluation for 
      laryngopharyngeal reflux (LPR), and the current reference standard is ambulatory 
      reflux monitoring.(1,3,4) This study of patients referred for evaluation of 
      chronic laryngeal symptoms had the following aims: (1) to characterize endoscopic 
      findings, (2) to discern whether findings differed between patients with or 
      without concomitant esophageal reflux symptoms, and (3) to measure the 
      association between endoscopic findings and objective GERD on ambulatory reflux 
      monitoring.
CI  - Copyright (c) 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Krause, Amanda J
AU  - Krause AJ
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, University 
      of California San Diego, La Jolla, California.
FAU - Carlson, Dustin A
AU  - Carlson DA
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg 
      School of Medicine, Northwestern University, Chicago, Illinois.
FAU - Chan, Walter W
AU  - Chan WW
AD  - Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, 
      Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, 
      Boston, Massachusetts.
FAU - Chen, Chien-Lin
AU  - Chen CL
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Hualien Tzu 
      Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, 
      Hualien, Taiwan.
FAU - Gyawali, C Prakash
AU  - Gyawali CP
AD  - Division of Gastroenterology, Department of Medicine, Washington University, St. 
      Louis, Missouri.
CN  - Laryngeal Symptoms Working Group
FAU - Yadlapati, Rena
AU  - Yadlapati R
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, University 
      of California San Diego, La Jolla, California. Electronic address: 
      ryadlapati@ucsd.edu.
LA  - eng
GR  - R01 DK092217/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20240124
PL  - United States
TA  - Clin Gastroenterol Hepatol
JT  - Clinical gastroenterology and hepatology : the official clinical practice journal 
      of the American Gastroenterological Association
JID - 101160775
SB  - IM
FIR - Greytak, Madeline
IR  - Greytak M
IRAD- Division of Gastroenterology and Hepatology, Department of Medicine, University 
      of California San Diego, La Jolla, California.
FIR - Kaizer, Alexander M
IR  - Kaizer AM
IRAD- Department of Biostatistics and Informatics, Colorado School of Public Health, 
      University of Colorado-Anschutz Medical Campus, Aurora, Colorado.
FIR - Jenkins, Andrew
IR  - Jenkins A
IRAD- Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, 
      Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, 
      Boston, Massachusetts.
FIR - Pandolfino, John E
IR  - Pandolfino JE
IRAD- Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg 
      School of Medicine, Northwestern University, Chicago, Illinois.
FIR - Polamraju, Vinathi
IR  - Polamraju V
IRAD- Division of Gastroenterology, Department of Medicine, Washington University, St. 
      Louis, Missouri.
FIR - Wong, Ming-Wun
IR  - Wong MW
IRAD- Division of Gastroenterology and Hepatology, Department of Medicine, Hualien Tzu 
      Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, 
      Hualien, Taiwan.
EDAT- 2024/01/27 12:42
MHDA- 2024/01/27 12:42
CRDT- 2024/01/26 19:12
PHST- 2023/09/21 00:00 [received]
PHST- 2023/11/07 00:00 [revised]
PHST- 2024/01/08 00:00 [accepted]
PHST- 2024/01/27 12:42 [pubmed]
PHST- 2024/01/27 12:42 [medline]
PHST- 2024/01/26 19:12 [entrez]
AID - S1542-3565(24)00087-9 [pii]
AID - 10.1016/j.cgh.2024.01.012 [doi]
PST - aheadofprint
SO  - Clin Gastroenterol Hepatol. 2024 Jan 24:S1542-3565(24)00087-9. doi: 
      10.1016/j.cgh.2024.01.012.