PMID- 38279138
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 22
IP  - 1
DP  - 2024 Jan 26
TI  - Multivariate analysis of prognostic factors in patients with lip squamous cell 
      carcinoma after surgery.
PG  - 35
LID - 10.1186/s12957-024-03313-9 [doi]
LID - 35
AB  - BACKGROUND: Lip squamous cell carcinoma (LSCC) was one of the most common cancer 
      types of head and neck tumors. This study aimed to find more predictors of the 
      prognosis in postoperative LSCC patients. METHODS: A total of 147 LSCC patients 
      between June 2012 and June 2018 were collected from two tertiary care 
      institutions. There were 21 clinicopathological factors included and analyzed in 
      our study. The univariate and multivariate Cox regression analyses were performed 
      to find the independent prognostic factors for predicting progression-free 
      survival (PFS) and overall survival (OS) in postoperative LSCC patients. The role 
      of adjuvant radiotherapy in various subgroups was displayed by Kaplan-Meier 
      plots. RESULTS: The 1-, 3-, and 5-year PFS of postoperative LSCC patients were 
      88.4%, 70.1%, and 57.8%, respectively. Similarly, the 1-, 3-, and 5-year OS of 
      postoperative LSCC patients were 94.6%, 76.9%, and 69.4%, respectively. The 
      results suggested that postoperative LSCC patients with age at 
      diagnosis >/= 70 years, grade with moderate or poor differentiate, the American 
      Joint Committee on Cancer (AJCC) stage IV, higher systemic immune-inflammation 
      index (SII), surgical margin < 5, and age-adjusted Charlson Comorbidity Index 
      (ACCI) >/= 5 tend to have a poorer PFS (all P < 0.05). Besides, postoperative LSCC 
      patients with age at diagnosis >/= 70 years, AJCC stage IV, higher GPS, higher SII, 
      and ACCI >/= 5 tend to have a worse OS (all P < 0.05). Additionally, postoperative 
      patients with LSCC in the subgroup of ACCI < 5 and AJCC III-IV stage was more 
      likely to benefit from adjuvant radiotherapy, but not for the other subgroups. 
      CONCLUSION: We identified a series of significant immune-inflammation-related and 
      comorbidity-related clinicopathological factors associated with the prognosis of 
      postoperative LSCC patients by local data from two tertiary care institutions in 
      China, which can be helpful for patients and surgeons to pay more attention to 
      nutrition, inflammation, and complications and finally obtained a better 
      prognosis.
CI  - (c) 2024. The Author(s).
FAU - Cheng, Hao
AU  - Cheng H
AD  - Department of Radiotherapy Oncology, The First Affiliated Hospital of Xinxiang 
      Medical University, 88 Jiankang Road, Xinxiang, Henan, 453100, China.
FAU - Xu, Jin-Hong
AU  - Xu JH
AD  - Department of Otolaryngology, Anyang District Hospital, Anyang, Henan, 455000, 
      China.
FAU - He, Jia-Qi
AU  - He JQ
AD  - Department of Radiotherapy Oncology, Affiliated Cancer Hospital of Zhengzhou 
      University, Zhengzhou, Henan, 450000, China.
FAU - Yang, Xi-Yang
AU  - Yang XY
AD  - Department of Radiotherapy Oncology, Yuanyang County People's Hospital, Xinxiang, 
      Henan, 453500, China.
FAU - Shen, Xu-Ning
AU  - Shen XN
AD  - Department of Radiotherapy Oncology, Yuanyang County People's Hospital, Xinxiang, 
      Henan, 453500, China.
FAU - Xu, Xue-Lian
AU  - Xu XL
AD  - Department of Radiotherapy Oncology, The First Affiliated Hospital of Xinxiang 
      Medical University, 88 Jiankang Road, Xinxiang, Henan, 453100, China. 
      xxl17651951833@163.com.
LA  - eng
GR  - LHGJ20200516/Joint Project of Henan Province and Ministry/
GR  - LHGJ20200500/the Joint Project of Henan Province and Ministry/
PT  - Journal Article
DEP - 20240126
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Humans
MH  - Aged
MH  - Prognosis
MH  - Lip
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - *Head and Neck Neoplasms
MH  - Inflammation
MH  - *Laryngeal Neoplasms/pathology
MH  - Retrospective Studies
PMC - PMC10811904
OTO - NOTNLM
OT  - Age-adjusted Charlson comorbidity index
OT  - Lip squamous cell carcinoma
OT  - Overall survival
OT  - Postoperative
OT  - Progression-free survival
COIS- The authors declare no competing interests.
EDAT- 2024/01/27 12:42
MHDA- 2024/01/29 06:44
PMCR- 2024/01/26
CRDT- 2024/01/26 23:30
PHST- 2023/09/08 00:00 [received]
PHST- 2024/01/13 00:00 [accepted]
PHST- 2024/01/29 06:44 [medline]
PHST- 2024/01/27 12:42 [pubmed]
PHST- 2024/01/26 23:30 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - 10.1186/s12957-024-03313-9 [pii]
AID - 3313 [pii]
AID - 10.1186/s12957-024-03313-9 [doi]
PST - epublish
SO  - World J Surg Oncol. 2024 Jan 26;22(1):35. doi: 10.1186/s12957-024-03313-9.