PMID- 38279291
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240206
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 2
DP  - 2024 Jan 20
TI  - Ionic Liquid-Based Polymer Matrices for Single and Dual Drug Delivery: Impact of 
      Structural Topology on Characteristics and In Vitro Delivery Efficiency.
LID - 10.3390/ijms25021292 [doi]
LID - 1292
AB  - Previously reported amphiphilic linear and graft copolymers, derived from the 
      ionic liquid [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA_Cl‾), 
      along with their conjugates obtained through modification either before or after 
      polymerization with p-aminosalicylate anions (TMAMA_PAS‾), were employed as 
      matrices in drug delivery systems (DDSs). Based on the counterion type in TMAMA 
      units, they were categorized into single drug systems, manifesting as ionic 
      polymers with chloride counterions and loaded isoniazid (ISO), and dual drug 
      systems, featuring ISO loaded in self-assembled PAS conjugates. The amphiphilic 
      nature of these copolymers was substantiated through the determination of the 
      critical micelle concentration (CMC), revealing an increase in values post-ion 
      exchange (from 0.011-0.063 mg/mL to 0.027-0.181 mg/mL). The self-assembling 
      properties were favorable for ISO encapsulation, with drug loading content (DLC) 
      ranging between 15 and 85% in both single and dual systems. In vitro studies 
      indicated ISO release percentages between 16 and 61% and PAS release percentages 
      between 20 and 98%. Basic cytotoxicity assessments using the 
      2,5-diphenyl-2H-tetrazolium bromide (MTT) test affirmed the non-toxicity of the 
      studied systems toward human non-tumorigenic lung epithelial cell line (BEAS-2B) 
      cell lines, particularly in the case of dual systems bearing both ISO and PAS 
      simultaneously. These results confirmed the effectiveness of polymeric carriers 
      in drug delivery, demonstrating their potential for co-delivery in combination 
      therapy.
FAU - Niesyto, Katarzyna
AU  - Niesyto K
AUID- ORCID: 0000-0003-0313-9772
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
FAU - Keihankhadiv, Shadi
AU  - Keihankhadiv S
AUID- ORCID: 0000-0002-1179-6724
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
FAU - Mazur, Aleksy
AU  - Mazur A
AUID- ORCID: 0000-0003-3276-7137
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
FAU - Mielanczyk, Anna
AU  - Mielanczyk A
AUID- ORCID: 0000-0001-5888-621X
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
FAU - Neugebauer, Dorota
AU  - Neugebauer D
AUID- ORCID: 0000-0002-3802-744X
AD  - Department of Physical Chemistry and Technology of Polymers, Faculty of 
      Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.
LA  - eng
GR  - grant no. 2017/27/B/ST5/00960/National Science Center/
GR  - BKM-546/RCH4/2023 (04/040/BKM23/0260)/Grant for Young Scientists from the 
      University/
GR  - BKM-549/RCH4/2023 (04/040/BKM23/0263)/Grant for Young Scientists from the 
      University/
PT  - Journal Article
DEP - 20240120
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Polymers)
RN  - 0 (Ionic Liquids)
RN  - 0 (Drug Carriers)
RN  - 0 (Chlorides)
RN  - 0 (Micelles)
SB  - IM
MH  - Humans
MH  - *Polymers/chemistry
MH  - *Ionic Liquids
MH  - Drug Carriers/chemistry
MH  - Chlorides
MH  - Drug Delivery Systems
MH  - Micelles
PMC - PMC10816880
OTO - NOTNLM
OT  - co-delivery systems
OT  - dual drug systems
OT  - graft copolymers
OT  - isoniazid
OT  - linear copolymers
OT  - p-aminosalicylate
OT  - poly(ionic liquid)s
OT  - single drug systems
COIS- The authors declare no conflicts of interest.
EDAT- 2024/01/27 12:44
MHDA- 2024/01/29 06:43
PMCR- 2024/01/20
CRDT- 2024/01/27 01:01
PHST- 2023/12/13 00:00 [received]
PHST- 2024/01/15 00:00 [revised]
PHST- 2024/01/18 00:00 [accepted]
PHST- 2024/01/29 06:43 [medline]
PHST- 2024/01/27 12:44 [pubmed]
PHST- 2024/01/27 01:01 [entrez]
PHST- 2024/01/20 00:00 [pmc-release]
AID - ijms25021292 [pii]
AID - ijms-25-01292 [pii]
AID - 10.3390/ijms25021292 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Jan 20;25(2):1292. doi: 10.3390/ijms25021292.