PMID- 38279752
OWN - NLM
STAT- Publisher
LR  - 20240127
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
DP  - 2024 Jan 25
TI  - Large B-cell Lymphoma with IRF4 Rearrangement in the Nasolacrimal Duct: A 
      Clinicopathological Study of One Case and Literature Review.
LID - 10.2174/0115665240272361231229122203 [doi]
AB  - BACKGROUND: Large B-cell lymphoma (LBCL) with interferon regulatory factor 4 
      (IRF4) rearrangement (LBCL-IRF4) is a rare subtype of LBCL, with a high 
      prevalence in Waldeyer's ring as well as the neck, head and gastrointestinal 
      lymph nodes. MATERIALS AND METHODS: A patient with 2-month clinical symptoms of 
      nasal obstruction and facial swelling was reported in this short review. A nasal 
      endoscopy examination revealed a neoplasm in the inferior nasal meatus. Both CT 
      and enhanced MRI showed that a soft tissue occupied the nasolacrimal duct, with 
      bone destruction, and extended into the left nasal cavity and left lacrimal gland 
      area. Then, a biopsy of the neoplasm in the inferior nasal meatus was performed. 
      RESULTS: HE staining results showed that neoplastic cells presented diffuse 
      growth patterns, abundant cytoplasm, vacuole shape, lightly stained nuclei, and 
      irregular nuclear membrane. Immunohistochemistry staining results revealed 
      MUM1(+), Bcl6(+), CD20(+), CD79alpha(+), and CD10(+). FISH analyses detected positive 
      IRF4 rearrangement. LBCL-IRF4 was diagnosed in the patient. The patient received 
      treatment with four cycles of R-CHOP and two times of rituximab, followed up for 
      2 years, and finally got complete remission. CONCLUSION: For the first time, we 
      summarize the imaging and pathological features, drug treatment, and curative 
      effect of LBCL-IRF4 in the nasolacrimal duct.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Chen, Wang-Xing
AU  - Chen WX
AD  - Department of Otolaryngology, The Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Yiwu, 322000, Zhejiang, China.
FAU - Wu, Jun
AU  - Wu J
AD  - Department of Otolaryngology, The Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Yiwu, 322000, Zhejiang, China.
FAU - He, Jian-Guo
AU  - He JG
AD  - Department of Otolaryngology, The Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Yiwu, 322000, Zhejiang, China.
LA  - eng
PT  - Case Reports
DEP - 20240125
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
SB  - IM
OTO - NOTNLM
OT  - IRF4 rearrangement
OT  - Large B-cell lymphoma
OT  - case report.
OT  - nasolacrimal duct
EDAT- 2024/01/27 12:44
MHDA- 2024/01/27 12:44
CRDT- 2024/01/27 05:29
PHST- 2023/08/23 00:00 [received]
PHST- 2023/12/09 00:00 [revised]
PHST- 2023/12/12 00:00 [accepted]
PHST- 2024/01/27 12:44 [medline]
PHST- 2024/01/27 12:44 [pubmed]
PHST- 2024/01/27 05:29 [entrez]
AID - CMM-EPUB-137906 [pii]
AID - 10.2174/0115665240272361231229122203 [doi]
PST - aheadofprint
SO  - Curr Mol Med. 2024 Jan 25. doi: 10.2174/0115665240272361231229122203.