PMID- 38281071
OWN - NLM
STAT- Publisher
LR  - 20240128
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
DP  - 2024 Jan 27
TI  - A path to Glucocorticoid Stewardship: a critical review of clinical 
      recommendations for the treatment of systemic lupus erythematosus.
LID - keae041 [pii]
LID - 10.1093/rheumatology/keae041 [doi]
AB  - Glucocorticoids (GCs) have revolutionized the management of SLE, providing 
      patients with rapid symptomatic relief and preventing flares when maintained at 
      low dosages. However, there are increasing concerns over GC-associated adverse 
      effects (AEs) and organ damage, which decrease patients' quality of life (QOL) 
      and increase healthcare costs. This highlights the need to balance effective GC 
      use and minimize toxicity in patients with SLE. Herein, we provide an overview of 
      the theoretical considerations and clinical evidence, in addition to the 
      variations and similarities across nine national and eight international 
      recommendations regarding the use of GCs across SLE manifestations and how these 
      compare with real-world usage. In line with this, we propose possible actions 
      toward the goal of GC Stewardship to improve the QOL for patients with lupus 
      while managing the disease burden.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Bertsias, George
AU  - Bertsias G
AUID- ORCID: 0000-0001-5299-1406
AD  - Rheumatology and Clinical Immunology, University of Crete Medical School, 
      Heraklion, Greece.
AD  - Institute of Molecular Biology and Biotechnology, Foundation for Research and 
      Technology-Hellas (FORTH), Heraklion, Greece.
FAU - Askanase, Anca
AU  - Askanase A
AUID- ORCID: 0000-0003-4597-5023
AD  - Columbia University Irving Medical Center, New York, NY, USA.
FAU - Doria, Andrea
AU  - Doria A
AUID- ORCID: 0000-0003-0548-4983
AD  - Division of Rheumatology, Department of Medicine, University of Padova, Italy.
FAU - Saxena, Amit
AU  - Saxena A
AUID- ORCID: 0000-0003-0098-1083
AD  - Division of Rheumatology, Department of Medicine, NYU Langone Health, New York, 
      NY, USA.
FAU - Vital, Edward M
AU  - Vital EM
AUID- ORCID: 0000-0003-1637-4755
AD  - Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 
      UK.
AD  - NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20240127
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
OTO - NOTNLM
OT  - Glucocorticoids
OT  - Lupus Nephritis
OT  - Lupus erythematosus
OT  - Systemic
EDAT- 2024/01/28 07:44
MHDA- 2024/01/28 07:44
CRDT- 2024/01/28 00:52
PHST- 2023/09/29 00:00 [received]
PHST- 2023/12/14 00:00 [revised]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/01/28 07:44 [medline]
PHST- 2024/01/28 07:44 [pubmed]
PHST- 2024/01/28 00:52 [entrez]
AID - 7590856 [pii]
AID - 10.1093/rheumatology/keae041 [doi]
PST - aheadofprint
SO  - Rheumatology (Oxford). 2024 Jan 27:keae041. doi: 10.1093/rheumatology/keae041.