PMID- 38281747
OWN - NLM
STAT- Publisher
LR  - 20240128
IS  - 1349-9092 (Electronic)
IS  - 0917-5040 (Linking)
DP  - 2024 Jan 27
TI  - Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers' Cohort 
      Study.
LID - 10.2188/jea.JE20230184 [doi]
AB  - BACKGROUND: The term "nonrestorative sleep (NRS)" refers to unrefreshed feeling 
      at wake-up and is a domain of poor sleep quality. Previous researches have 
      demonstrated that NRS is linked to a number of diseases and adverse health 
      outcomes, but less is known regarding the link between NRS and diabetes, 
      particularly in Japanese. METHODS: We studied 3665 middle-aged male participants 
      of the Aichi Workers' Cohort Study who were followed-up from 2002 to 2019. Cox 
      proportional hazards models estimated hazard ratios (HRs) and 95% confidence 
      intervals (CIs) of incident type 2 diabetes mellitus (T2DM) in relation to NRS 
      adjusted for potential confounding variables. RESULTS: During a median follow-up 
      of 14.6 years, 421 type 2 diabetes cases were identified. Participants with NRS 
      had a higher crude incidence rate of T2DM (11.2/1,000 person-years), compared to 
      participants without NRS (9.3/1,000 person-years). In the fully adjusted model, 
      individuals who reported having NRS had a significantly higher risk of developing 
      T2DM (HR: 1.36, 95% CI: 1.10-1.67). The association was observed only in 
      participants under 50 years old (HR: 1.82, 95% CI: 1.36-2.43), not in the older 
      (50 years or older) participants (P for interaction =0.025). In contrast, 
      stratified analyses by the presence of shift work, obesity or sleep duration 
      showed similar associations in all the strata. CONCLUSIONS: NRS was associated 
      with higher risk of T2DM in middle-aged Japanese male workers independent of a 
      variety of lifestyle factors and other sleep problems.
FAU - Lin, Jingyi
AU  - Lin J
AUID- ORCID: 0009-0002-5729-0064
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Song, Zean
AU  - Song Z
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Li, Yuanying
AU  - Li Y
AUID- ORCID: 0000-0002-4059-6406
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Chiang, Chifa
AU  - Chiang C
AUID- ORCID: 0000-0002-6161-1249
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Hirakawa, Yoshihisa
AU  - Hirakawa Y
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Nakano, Yoshihisa
AU  - Nakano Y
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Hong, Young-Jae
AU  - Hong YJ
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
FAU - Matsunaga, Masaaki
AU  - Matsunaga M
AD  - Department of Public Health, Fujita Health University School of Medicine.
FAU - Ota, Atsuhiko
AU  - Ota A
AD  - Department of Public Health, Fujita Health University School of Medicine.
FAU - Tamakoshi, Koji
AU  - Tamakoshi K
AD  - Department of Nursing, Nagoya University Graduate School of Medicine.
FAU - Yatsuya, Hiroshi
AU  - Yatsuya H
AD  - Department of Public Health and Health System, Nagoya University Graduate School 
      of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20240127
PL  - Japan
TA  - J Epidemiol
JT  - Journal of epidemiology
JID - 9607688
SB  - IM
OTO - NOTNLM
OT  - Japanese
OT  - cohort study
OT  - diabetes
OT  - nonrestorative sleep
EDAT- 2024/01/29 00:42
MHDA- 2024/01/29 00:42
CRDT- 2024/01/28 21:03
PHST- 2024/01/29 00:42 [medline]
PHST- 2024/01/29 00:42 [pubmed]
PHST- 2024/01/28 21:03 [entrez]
AID - 10.2188/jea.JE20230184 [doi]
PST - aheadofprint
SO  - J Epidemiol. 2024 Jan 27. doi: 10.2188/jea.JE20230184.