PMID- 38281785
OWN - NLM
STAT- MEDLINE
DCOM- 20240130
LR  - 20240206
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 53
IP  - 2
DP  - 2024 Feb 8
TI  - [Well-differentiated/dedifferentiated liposarcoma associated with myxoid-like 
      morphology: a clinicopathological and molecular genetic characteristics analysis 
      of 34 cases].
PG  - 168-173
LID - 10.3760/cma.j.cn112151-20231025-00302 [doi]
AB  - Objective: To investigate the clinicopathological and molecular genetic 
      characteristics of well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) 
      with myxoid-like morphology, and to distinguish them from myxofibrosarcoma (MFS) 
      with similar morphology. Methods: Twenty-nine cases of myxoid-like liposarcoma 
      and 5 cases of MFS were collected from Henan Provincial People's Hospital, 
      Zhengzhou, China and the First Medical Center of PLA General Hospital, Beijing, 
      China from January 2015 to March 2023. Relevant markers were detected using 
      immunohistochemistry and fluorescence in situ hybridization (FISH). The 
      literature was also reviewed. Results: There were 24 males and 10 females, with 
      ages ranging from 41 to 73 years. The tumor sites included retroperitoneum 
      (n=17), abdomen (n=9), lower limbs (n=5), scrotum (n=1), upper limb (n=1) and 
      axilla (n=1). WDLPS was commonly seen as lipomatoid type (12 cases), while the 
      dedifferentiated components of DDLPS included low-grade (13 cases) and high-grade 
      (2 cases) morphology, with low-high grade myxofibrosarcoma, dermatofibrosarcoma 
      protuberans, and low-grade fibrosarcoma structures. Twenty-nine liposarcomas had 
      various proportions of myxoid-like morphology, while 16 showed various degrees of 
      tumor necrosis. The myxoid-like component showed myxoid pleomorphic liposarcoma 
      (MLPS)-like morphology, lobulated growth, characteristic slender, ramified 
      capillary network,"chicken claw-like"morphology, mucus-rich stroma and lung 
      edema-like morphology. Tumor cells were spindle and oval, with many variable 
      vacuolar lipoblasts. MDM2 gene amplification was detected using FISH and present 
      in all tested cases (29/29). DDIT3 break-apart mutation was not detected, but its 
      cluster amplification was present (24/29). Among the MFS cases, one showed 
      cluster amplification (1/5), but no cases showed break-apart or amplification of 
      MDM2 gene. Conclusions: WDLPS/DDLPS with myxoid-like morphology is most commonly 
      seen in the retroperitoneum and abdominal cavity and mostly harbors DDIT3 
      break-apart probe amplification, while this amplification is not specific to 
      liposarcoma. For core biopsy specimens or very rare tumors in the limbs, when 
      histology has mucinous stroma and MLPS-like morphology, misdiagnosis of MLPS or 
      other non-lipomatous neoplasms with myxoid morphology should be avoided.
FAU - Xue, S
AU  - Xue S
AD  - Department of Pathology, Henan Provincial People's Hospital, the People's 
      Hospital of Zhengzhou University, Zhengzhou 450003, China.
FAU - Liu, Q Y
AU  - Liu QY
AD  - Department of Pathology, Henan Provincial People's Hospital, the People's 
      Hospital of Zhengzhou University, Zhengzhou 450003, China.
FAU - Gou, X N
AU  - Gou XN
AD  - Department of Pathology, the First Medical Center of People's Liberation Army 
      General Hospital, Beijing 100853, China.
FAU - Zhao, Y W
AU  - Zhao YW
AD  - Department of Pathology, Henan Provincial People's Hospital, the People's 
      Hospital of Zhengzhou University, Zhengzhou 450003, China.
FAU - Cheng, Q
AU  - Cheng Q
AD  - Department of Pathology, Henan Provincial People's Hospital, the People's 
      Hospital of Zhengzhou University, Zhengzhou 450003, China.
FAU - Kong, L F
AU  - Kong LF
AD  - Department of Pathology, Henan Provincial People's Hospital, the People's 
      Hospital of Zhengzhou University, Zhengzhou 450003, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Male
MH  - Female
MH  - Adult
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Liposarcoma/pathology
MH  - *Lipoma/pathology
MH  - *Fibrosarcoma
MH  - Molecular Biology
MH  - Proto-Oncogene Proteins c-mdm2/genetics
MH  - *Liposarcoma, Myxoid/genetics/pathology
EDAT- 2024/01/29 00:42
MHDA- 2024/01/30 12:44
CRDT- 2024/01/28 21:07
PHST- 2024/01/30 12:44 [medline]
PHST- 2024/01/29 00:42 [pubmed]
PHST- 2024/01/28 21:07 [entrez]
AID - 10.3760/cma.j.cn112151-20231025-00302 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2024 Feb 8;53(2):168-173. doi: 
      10.3760/cma.j.cn112151-20231025-00302.