PMID- 38283001
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240131
IS  - 2229-5178 (Print)
IS  - 2249-5673 (Electronic)
IS  - 2229-5178 (Linking)
VI  - 15
IP  - 1
DP  - 2024 Jan-Feb
TI  - Is Atopic Dermatitis a Risk Factor for Thyroid Autoimmunity? - A Cross-Sectional 
      Study from a Tertiary Care Center in India.
PG  - 45-48
LID - 10.4103/idoj.idoj_48_23 [doi]
AB  - BACKGROUND: Because of the counter-regulation of Th1 and Th2 cells, Th1-type 
      autoimmune diseases like thyroid autoimmunity and Th2-mediated allergic diseases 
      like atopic dermatitis (AD) should occur in mutually exclusive populations. 
      However, thyroid autoimmunity has been associated with chronic urticaria, and 
      atopy is considered a cause of both AD and urticaria. OBJECTIVES: To assess the 
      frequency of thyroid autoimmunity in children with AD and to study the 
      correlation between the clinical severity of AD using the SCORing Atopic 
      Dermatitis (SCORAD) score, and biochemical parameters of serum immunoglobulin E 
      (IgE), absolute eosinophil count, and vitamin D levels. MATERIALS AND METHODS: A 
      hospital-based cross-sectional study was conducted, recruiting children (0-18 
      years) with AD. Patients on drugs affecting thyroid dysfunction and those with 
      sick euthyroid syndrome or an immunodeficiency disorder were excluded. Clinical 
      severity was assessed using SCORAD, and the thyroid profile, anti-thyroid 
      peroxidase antibodies, antinuclear antibody (ANA), absolute eosinophil count, 
      serum IgE, and vitamin D levels were measured. RESULTS: Thyroid autoimmunity was 
      diagnosed in 18.9% (10/53) of children. There was a significant correlation 
      between SCORAD and serum IgE (r = 0.432, P = 0.002) and absolute eosinophil count 
      (r = 0.575, P = <0.001). There was a negative correlation between SCORAD and 
      vitamin D levels (r = -0.373, P = 0.006). CONCLUSIONS: Thyroid autoimmunity may 
      be associated with AD, and a high index of suspicion is essential. Vitamin D also 
      should be supplemented in children with AD as it is frequently found to be low, 
      especially in severe cases. Multi-center case-control studies are required to 
      determine the prevalence of thyroid autoimmunity in children with AD.
CI  - Copyright: (c) 2023 Indian Dermatology Online Journal.
FAU - Mendiratta, Vibhu
AU  - Mendiratta V
AD  - Department of Dermatology and STD, Lady Hardinge Medical College and Associated 
      Hospitals, New Delhi, India.
FAU - Himadri, Himadri
AU  - Himadri H
AD  - Department of Dermatology and STD, Lady Hardinge Medical College and Associated 
      Hospitals, New Delhi, India.
FAU - Verma, Damini
AU  - Verma D
AD  - Department of Dermatology and STD, Lady Hardinge Medical College and Associated 
      Hospitals, New Delhi, India.
FAU - Aggarwal, Meenakshi
AU  - Aggarwal M
AD  - Department of Microbiology, Lady Hardinge Medical College and Associated 
      Hospitals, New Delhi, India.
FAU - Yadav, Jyoti
AU  - Yadav J
AD  - Department of Dermatology and STD, Lady Hardinge Medical College and Associated 
      Hospitals, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - India
TA  - Indian Dermatol Online J
JT  - Indian dermatology online journal
JID - 101586880
PMC - PMC10810387
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - biomarkers
OT  - thyroid autoimmunity
COIS- There are no conflicts of interest.
EDAT- 2024/01/29 06:42
MHDA- 2024/01/29 06:43
PMCR- 2023/12/01
CRDT- 2024/01/29 04:13
PHST- 2023/01/18 00:00 [received]
PHST- 2023/04/20 00:00 [revised]
PHST- 2023/04/26 00:00 [accepted]
PHST- 2024/01/29 06:43 [medline]
PHST- 2024/01/29 06:42 [pubmed]
PHST- 2024/01/29 04:13 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - IDOJ-15-45 [pii]
AID - 10.4103/idoj.idoj_48_23 [doi]
PST - epublish
SO  - Indian Dermatol Online J. 2023 Dec 1;15(1):45-48. doi: 10.4103/idoj.idoj_48_23. 
      eCollection 2024 Jan-Feb.