PMID- 38283396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240131
IS  - 2627-1850 (Electronic)
IS  - 2627-1850 (Linking)
VI  - 4
IP  - 4
DP  - 2022 Dec
TI  - Survival intravascular photoacoustic imaging of lipid-rich plaque in cholesterol 
      fed rabbits.
LID - e202200012 [pii]
LID - 10.1002/tbio.202200012 [doi]
AB  - Intravascular photoacoustic (IVPA) imaging is a promising modality for 
      quantitative assessment of lipid-laden atherosclerotic plaques. Yet, survival 
      IVPA imaging of the same plaque in the same animal is not demonstrated. Here, 
      using a sheathed IVUS/PA catheter of 0.9 mm in diameter, we demonstrate 
      MRI-guided survival IVPA imaging of same plaque in an aorta of a well-established 
      rabbit model mimicking atherosclerosis in human patients. The IVUS/PA results 
      were confirmed by histology. These advances open the opportunity to evaluate the 
      effectiveness of a therapy that aims to reduce the size of atherosclerotic 
      plaques and demonstrates the potential of translating the IVPA catheter into 
      clinic for detection of lipid-rich plaques that are at high risk for thrombosis.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Physics, Boston University, Boston, 02215, USA.
FAU - Taylor, Erik
AU  - Taylor E
AD  - Department of Physiology and Biophysics, Boston University School of Medicine, 
      Boston, 02118, USA.
FAU - Huang, Nasi
AU  - Huang N
AD  - Department of Physiology and Biophysics, Boston University School of Medicine, 
      Boston, 02118, USA.
FAU - Hamilton, James
AU  - Hamilton J
AD  - Department of Physiology and Biophysics, Boston University School of Medicine, 
      Boston, 02118, USA.
FAU - Cheng, Ji-Xin
AU  - Cheng JX
AD  - Department of Physics, Boston University, Boston, 02215, USA.
AD  - Department of Biomedical Engineering, Boston University, Boston, 02215, USA.
AD  - Department of Electrical and Computer Engineering, Boston University, Boston, 
      02215, USA.
LA  - eng
GR  - R01 HL125385/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20220904
PL  - Germany
TA  - Transl Biophotonics
JT  - Translational biophotonics
JID - 101767490
PMC - PMC10812843
MID - NIHMS1915841
EDAT- 2022/12/01 00:00
MHDA- 2022/12/01 00:01
PMCR- 2024/01/26
CRDT- 2024/01/29 04:27
PHST- 2022/12/01 00:01 [medline]
PHST- 2022/12/01 00:00 [pubmed]
PHST- 2024/01/29 04:27 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - e202200012 [pii]
AID - 10.1002/tbio.202200012 [doi]
PST - ppublish
SO  - Transl Biophotonics. 2022 Dec;4(4):e202200012. doi: 10.1002/tbio.202200012. Epub 
      2022 Sep 4.