PMID- 38283461 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240131 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 15 IP - 12 DP - 2023 Dec TI - Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) Among Diabetic Mellitus Patients in Saudi Arabia: Systematic Review and Meta-Analysis. PG - e51092 LID - 10.7759/cureus.51092 [doi] LID - e51092 AB - Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global health concern, closely associated with the rising prevalence of type 2 diabetes mellitus (T2DM) and obesity. This systematic review and meta-analysis aim to comprehensively evaluate the prevalence of NAFLD in DM patients in Saudi Arabia, a country undergoing rapid socioeconomic changes. Our multifaceted search strategy identified four high-quality studies conducted between 2003 and 2022, covering hospital and community settings. The aggregate prevalence rate of NAFLD in DM patients was notably high, ranging from 47.8% to 72.8%. However, substantial heterogeneity (I(2) = 90.6%) was observed, indicating variability attributed to diverse study characteristics. The uniform application of ultrasound for diagnosis was noteworthy but raised concerns regarding sensitivity. This analysis underscores the urgency of public health measures for early detection and management of NAFLD in DM-prone populations in Saudi Arabia. CI - Copyright (c) 2023, Albeshry et al. FAU - Albeshry, Abdulrahman M AU - Albeshry AM AD - Family and Community Medicine, Faculty of Medicine, University of Jeddah, Jeddah, SAU. FAU - Abdulrahman Alasmari, Mohammed AU - Abdulrahman Alasmari M AD - Medicine, King Khalid University, Abha, SAU. FAU - Alshahrani, Jaber Abdullah AU - Alshahrani JA AD - Family Medicine and Medical Education, Armed Forces Hospital Southern Region, Khamis Mushit, SAU. FAU - Alshahrani, Alaa Mohammed AU - Alshahrani AM AD - Family Medicine, Armed Forces Hospital Southern Region, Khamis Mushit, SAU. FAU - Saad Almusma, Abdulmajeed AU - Saad Almusma A AD - Family Medicine, Armed Forces Hospital Southern Region, Khamis Mushit, SAU. FAU - Alfaya, Mohammed A AU - Alfaya MA AD - Family Medicine, Armed Forces Hospital Southern Region, Khamis Mushit, SAU. FAU - Alfaifi, Ali J AU - Alfaifi AJ AD - Family and Community Medicine, King Khalid University, Abha, SAU. FAU - Alshahrani, Mastoor A AU - Alshahrani MA AD - Family Medicine, Primary Health Care Corporation (PHCC) Khamis Mushait Sector, Ministry of Health, Khamis Mushit, SAU. FAU - Alharbi, Hamad Khulaif D AU - Alharbi HKD AD - Medicine, Al Jouf University, Sakaka, SAU. FAU - Ali Etwdi, Ali S AU - Ali Etwdi AS AD - Laboratory, Armed Forces Hospital Southern Region, Khamis Mushit, SAU. FAU - Aldawsari, Eyad AU - Aldawsari E AD - Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU. FAU - Zakir Hiyat Moazam, Sundus Mohammad AU - Zakir Hiyat Moazam SM AD - Family Medicine, Alhaqbani Medical Complex, Khamis Mushait, SAU. FAU - Alshaiban, Mohammed AU - Alshaiban M AD - Medicine, Najran University, Najran, SAU. FAU - Al-Harthi, Saad N AU - Al-Harthi SN AD - Medicine, King Faisal University, Dammam, SAU. LA - eng PT - Journal Article PT - Review DEP - 20231225 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC10810724 OTO - NOTNLM OT - diabetes type 2 OT - dm OT - fatty liver disease OT - nafld OT - non-alcoholic OT - prevalence OT - systematic review and meta-analysis COIS- The authors have declared that no competing interests exist. EDAT- 2024/01/29 06:43 MHDA- 2024/01/29 06:44 PMCR- 2023/12/25 CRDT- 2024/01/29 04:29 PHST- 2023/12/23 00:00 [accepted] PHST- 2024/01/29 06:44 [medline] PHST- 2024/01/29 06:43 [pubmed] PHST- 2024/01/29 04:29 [entrez] PHST- 2023/12/25 00:00 [pmc-release] AID - 10.7759/cureus.51092 [doi] PST - epublish SO - Cureus. 2023 Dec 25;15(12):e51092. doi: 10.7759/cureus.51092. eCollection 2023 Dec.