PMID- 38283482
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240131
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 12
DP  - 2023 Dec
TI  - Sodium-Glucose Cotransporter-2 Inhibitor-Induced Euglycemic Diabetic Ketoacidosis 
      in a Type 2 Diabetic Patient.
PG  - e51184
LID - 10.7759/cureus.51184 [doi]
LID - e51184
AB  - Euglycemic diabetic ketoacidosis (euDKA) is a life-threatening metabolic 
      complication typically associated with type 1 diabetes mellitus (T1DM). However, 
      its occurrence in type 2 diabetes mellitus (T2DM) remains exceptionally rare. We 
      present a case report detailing the unusual manifestation of euDKA in a patient 
      with T2DM following the initiation of treatment with a sodium-glucose 
      cotransporter-2 (SGLT-2) inhibitor. The patient, a 67-year-old female with a 
      history of T2DM and well-controlled blood glucose levels, was commenced on an 
      SGLT-2 inhibitor as part of her antidiabetic regimen just two weeks prior. 
      Subsequently, the patient developed euDKA despite maintaining near-normal 
      glycemic levels. This paradoxical presentation challenges the conventional 
      understanding of DKA in T2DM and underscores the need for heightened clinical 
      awareness. EuDKA associated with SGLT-2 inhibitors is an infrequently reported 
      phenomenon, further complicating the clinical landscape. This case contributes to 
      the growing evidence suggesting an association between SGLT-2 inhibitors and the 
      development of euDKA in patients with T2DM. The rarity of this occurrence 
      necessitates a thorough exploration of potential risk factors and underlying 
      mechanisms.
CI  - Copyright (c) 2023, Haddadin et al.
FAU - Haddadin, Rakahn
AU  - Haddadin R
AD  - Medicine, MountainView Hospital, Las Vegas, USA.
FAU - Aboujamra, Danny
AU  - Aboujamra D
AD  - Internal Medicine, St. George's University School of Medicine, Las Vegas, USA.
FAU - Iraninezhad, Homayon
AU  - Iraninezhad H
AD  - Gastroenterology, MountainView Hospital, Las Vegas, USA.
LA  - eng
PT  - Case Reports
DEP - 20231227
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10817760
OTO - NOTNLM
OT  - adult gastroenterology
OT  - gastroenterology hepatology
OT  - general internal medicine
OT  - medication-induced pancreatitis
OT  - sodium-glucose cotransporter-2 (sglt-2) inhibitors
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/01/29 06:43
MHDA- 2024/01/29 06:44
PMCR- 2023/12/27
CRDT- 2024/01/29 04:30
PHST- 2023/12/27 00:00 [accepted]
PHST- 2024/01/29 06:44 [medline]
PHST- 2024/01/29 06:43 [pubmed]
PHST- 2024/01/29 04:30 [entrez]
PHST- 2023/12/27 00:00 [pmc-release]
AID - 10.7759/cureus.51184 [doi]
PST - epublish
SO  - Cureus. 2023 Dec 27;15(12):e51184. doi: 10.7759/cureus.51184. eCollection 2023 
      Dec.